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ZFIN:jak2a

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Contents

Species (Taxon ID) Danio rerio (zebrafish) (taxon:7955)
Gene Name(s) jak2a
Protein Name(s) Janus kinase 2a,
External Links
ZFIN ZDB-GENE-980526-481

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From ZFIN

GO:0004672

protein kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

F

From ZFIN

GO:0004672

protein kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001245

F

From ZFIN

GO:0004713

protein tyrosine kinase activity

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0829

F

From ZFIN

GO:0004713

protein tyrosine kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR008266

F

From ZFIN

GO:0004713

protein tyrosine kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR020635

F

From ZFIN

GO:0004715

non-membrane spanning protein tyrosine kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016251

F

From ZFIN

GO:0004715

non-membrane spanning protein tyrosine kinase activity

ZFIN:ZDB-PUB-031118-3

IEA: Inferred from Electronic Annotation

EC:2.7.10.2

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016251

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR017441

F

From ZFIN

GO:0005622

intracellular

ZFIN:ZDB-PUB-090929-3
PMID:19772888[1]

IMP: Inferred from Mutant Phenotype

C

From ZFIN

GO:0005856

cytoskeleton

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000299

C

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

P

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001245

P

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR008266

P

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016251

P

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR020635

P

From ZFIN

GO:0007243

intracellular protein kinase cascade

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016251

P

From ZFIN

GO:0007259

JAK-STAT cascade

ZFIN:ZDB-PUB-090929-3
PMID:19772888[1]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

GO:0016020

membrane

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016251

C

From ZFIN

GO:0016301

kinase activity

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

From ZFIN

GO:0016310

phosphorylation

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

From ZFIN

GO:0016740

transferase activity

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

From ZFIN

GO:0016772

transferase activity, transferring phosphorus-containing groups

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR011009

F

From ZFIN

GO:0030097

hemopoiesis

ZFIN:ZDB-PUB-081217-15
PMID:19059211[2]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

GO:0030218

erythrocyte differentiation

ZFIN:ZDB-PUB-090929-3
PMID:19772888[1]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-100427-10

P

From ZFIN

GO:0030218

erythrocyte differentiation

ZFIN:ZDB-PUB-090929-3
PMID:19772888[1]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

ZFIN:ZDB-PUB-060210-15
PMID:16459186[3]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0046427

positive regulation of JAK-STAT cascade

ZFIN:ZDB-PUB-060210-15
PMID:16459186[3]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0048514

blood vessel morphogenesis

ZFIN:ZDB-PUB-081217-15
PMID:19059211[2]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

GO:0060215

primitive hemopoiesis

ZFIN:ZDB-PUB-070625-7
PMID:17545503[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080428-1

P

From ZFIN

GO:0060215

primitive hemopoiesis

ZFIN:ZDB-PUB-070625-7
PMID:17545503[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080430-1

P

From ZFIN


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 Ma AC et al. (2009) A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera. Exp Hematol 37: 1379-1386.e4 PubMed GONUTS page
  2. 2.0 2.1 Sung JJ et al. (2009) Zebrafish Jak2a plays a crucial role in definitive hematopoiesis and blood vessel formation. Biochem Biophys Res Commun 378: 629-33 PubMed GONUTS page
  3. 3.0 3.1 Lewis RS et al. (2006) Constitutive activation of zebrafish Stat5 expands hematopoietic cell populations in vivo. Exp Hematol 34: 179-87 PubMed GONUTS page
  4. 4.0 4.1 Ma AC et al. (2007) The role of jak2a in zebrafish hematopoiesis. Blood 110: 1824-30 PubMed GONUTS page
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