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ZFIN:ilk

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Contents

Species (Taxon ID) Danio rerio (zebrafish) (taxon:7955)
Gene Name(s) ilk
Protein Name(s) integrin linked kinase,
External Links
ZFIN ZDB-GENE-040426-1435

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001568

blood vessel development

ZFIN:ZDB-PUB-061221-2
PMID:15340074[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-061222-1

P

From ZFIN

GO:0004672

protein kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

F

From ZFIN

GO:0004672

protein kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001245

F

From ZFIN

GO:0004672

protein kinase activity

ZFIN:ZDB-PUB-060825-15
PMID:16921028[2]

IDA: Inferred from Direct Assay

F

From ZFIN

GO:0004672

protein kinase activity

ZFIN:ZDB-PUB-060825-15
PMID:16921028[2]

IMP: Inferred from Mutant Phenotype

F

From ZFIN

GO:0004674

protein serine/threonine kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016253

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

F

From ZFIN

GO:0005737

cytoplasm

ZFIN:ZDB-PUB-080429-10
PMID:18436206[3]

IDA: Inferred from Direct Assay

C

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

P

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001245

P

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016253

P

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-060825-15
PMID:16921028[2]

IC: Inferred by Curator

GO:0004672

P

From ZFIN

GO:0007160

cell-matrix adhesion

ZFIN:ZDB-PUB-080429-10
PMID:18436206[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-061219-1

P

From ZFIN

GO:0007229

integrin-mediated signaling pathway

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0401

P

From ZFIN

GO:0008016

regulation of heart contraction

ZFIN:ZDB-PUB-060825-15
PMID:16921028[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-366

P

From ZFIN

GO:0008016

regulation of heart contraction

ZFIN:ZDB-PUB-060825-15
PMID:16921028[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060921-4

P

From ZFIN

GO:0008016

regulation of heart contraction

ZFIN:ZDB-PUB-060825-15
PMID:16921028[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-061219-1

P

From ZFIN

GO:0009966

regulation of signal transduction

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016253

P

From ZFIN

GO:0016203

muscle attachment

ZFIN:ZDB-PUB-080429-10
PMID:18436206[3]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-080130-1
ZFIN:ZDB-MRPHLNO-051215-1

P

From ZFIN

GO:0016203

muscle attachment

ZFIN:ZDB-PUB-080429-10
PMID:18436206[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080130-1

P

From ZFIN

GO:0016203

muscle attachment

ZFIN:ZDB-PUB-080429-10
PMID:18436206[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-061219-1

P

From ZFIN

GO:0016301

kinase activity

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

From ZFIN

GO:0016310

phosphorylation

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

From ZFIN

GO:0016772

transferase activity, transferring phosphorus-containing groups

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR011009

F

From ZFIN

GO:0030018

Z disc

ZFIN:ZDB-PUB-060825-15
PMID:16921028[2]

IDA: Inferred from Direct Assay

C

From ZFIN

GO:0030018

Z disc

ZFIN:ZDB-PUB-110628-16
PMID:21670146[4]

IDA: Inferred from Direct Assay

C

From ZFIN

GO:0042383

sarcolemma

ZFIN:ZDB-PUB-060825-15
PMID:16921028[2]

IDA: Inferred from Direct Assay

C

From ZFIN

GO:0060047

heart contraction

ZFIN:ZDB-PUB-091023-12
PMID:19800866[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060921-4

P

From ZFIN

GO:0060047

heart contraction

ZFIN:ZDB-PUB-110628-16
PMID:21670146[4]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-110907-4

P

From ZFIN

GO:0060047

heart contraction

ZFIN:ZDB-PUB-110628-16
PMID:21670146[4]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-110907-6

P

From ZFIN


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Friedrich EB et al. (2004) Integrin-linked kinase regulates endothelial cell survival and vascular development. Mol Cell Biol 24: 8134-44 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Bendig G et al. (2006) Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes Dev 20: 2361-72 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Postel R et al. (2008) Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex. Dev Biol 318: 92-101 PubMed GONUTS page
  4. 4.0 4.1 4.2 Meder B et al. (2011) PINCH proteins regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling. Mol Cell Biol 31: 3424-35 PubMed GONUTS page
  5. Vogel B et al. (2009) In-vivo characterization of human dilated cardiomyopathy genes in zebrafish. Biochem Biophys Res Commun 390: 516-22 PubMed GONUTS page
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