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ZFIN:igf1rb

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Contents

Species (Taxon ID) Danio rerio (zebrafish) (taxon:7955)
Gene Name(s) igf1rb
Protein Name(s) insulin-like growth factor 1b receptor,
External Links
ZFIN ZDB-GENE-020503-2

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From ZFIN

GO:0003007

heart morphogenesis

ZFIN:ZDB-PUB-070303-43
PMID:17332774[1]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-061130-3
ZFIN:ZDB-MRPHLNO-061130-4
ZFIN:ZDB-MRPHLNO-061130-5
ZFIN:ZDB-MRPHLNO-061130-6

P

From ZFIN

GO:0004672

protein kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

F

From ZFIN

GO:0004672

protein kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001245

F

From ZFIN

GO:0004713

protein tyrosine kinase activity

ZFIN:ZDB-PUB-020429-3
PMID:11956169[2]

ISS: Inferred from Sequence or Structural Similarity

InterPro:IPR001245

F

From ZFIN

GO:0004713

protein tyrosine kinase activity

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0829

F

From ZFIN

GO:0004713

protein tyrosine kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR008266

F

From ZFIN

GO:0004713

protein tyrosine kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR020635

F

From ZFIN

GO:0004714

transmembrane receptor protein tyrosine kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR002011

F

From ZFIN

GO:0004714

transmembrane receptor protein tyrosine kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR006211

F

From ZFIN

GO:0004714

transmembrane receptor protein tyrosine kinase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016246

F

From ZFIN

GO:0004714

transmembrane receptor protein tyrosine kinase activity

ZFIN:ZDB-PUB-031118-3

IEA: Inferred from Electronic Annotation

EC:2.7.10.1

F

From ZFIN

GO:0004872

receptor activity

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0675

F

From ZFIN

GO:0005520

insulin-like growth factor binding

ZFIN:ZDB-PUB-020429-3
PMID:11956169[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q90VV9

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR002011

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR006211

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016246

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR017441

F

From ZFIN

GO:0005624

membrane fraction

ZFIN:ZDB-PUB-020429-3
PMID:11956169[2]

IDA: Inferred from Direct Assay

C

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

P

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001245

P

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR002011

P

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR006211

P

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR008266

P

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016246

P

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR020635

P

From ZFIN

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR002011

P

From ZFIN

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR006211

P

From ZFIN

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016246

P

From ZFIN

GO:0007507

heart development

ZFIN:ZDB-PUB-060531-4
PMID:16705083[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-061130-5
ZFIN:ZDB-MRPHLNO-061130-6

P

From ZFIN

GO:0008354

germ cell migration

ZFIN:ZDB-PUB-070330-12
PMID:17362906[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-061130-5
ZFIN:ZDB-MRPHLNO-061130-6

P

From ZFIN

GO:0008354

germ cell migration

ZFIN:ZDB-PUB-080622-26
PMID:18566124[5]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

GO:0009790

embryo development

ZFIN:ZDB-PUB-060531-4
PMID:16705083[3]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-020503-1

P

From ZFIN

GO:0009790

embryo development

ZFIN:ZDB-PUB-060531-4
PMID:16705083[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-061130-5

P

From ZFIN

GO:0009790

embryo development

ZFIN:ZDB-PUB-060531-4
PMID:16705083[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-061130-5
ZFIN:ZDB-MRPHLNO-061130-6

P

From ZFIN

GO:0009790

embryo development

ZFIN:ZDB-PUB-060531-4
PMID:16705083[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-061130-6

P

From ZFIN

GO:0016020

membrane

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From ZFIN

GO:0016020

membrane

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000494

C

From ZFIN

GO:0016020

membrane

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR002011

C

From ZFIN

GO:0016020

membrane

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR006211

C

From ZFIN

GO:0016021

integral to membrane

ZFIN:ZDB-PUB-020429-3
PMID:11956169[2]

ISS: Inferred from Sequence or Structural Similarity

C

From ZFIN

GO:0016021

integral to membrane

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From ZFIN

GO:0016021

integral to membrane

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016246

C

From ZFIN

GO:0016301

kinase activity

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

From ZFIN

GO:0016310

phosphorylation

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

From ZFIN

GO:0016740

transferase activity

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

From ZFIN

GO:0016772

transferase activity, transferring phosphorus-containing groups

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR011009

F

From ZFIN

GO:0021522

spinal cord motor neuron differentiation

ZFIN:ZDB-PUB-060531-4
PMID:16705083[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-061130-5
ZFIN:ZDB-MRPHLNO-061130-6

P

From ZFIN

GO:0031076

embryonic camera-type eye development

ZFIN:ZDB-PUB-070303-43
PMID:17332774[1]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-061130-3
ZFIN:ZDB-MRPHLNO-061130-4
ZFIN:ZDB-MRPHLNO-061130-5
ZFIN:ZDB-MRPHLNO-061130-6

P

From ZFIN

GO:0031101

fin regeneration

ZFIN:ZDB-PUB-100322-19
PMID:20179093[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-061130-5

P

From ZFIN

GO:0043010

camera-type eye development

ZFIN:ZDB-PUB-060531-4
PMID:16705083[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-061130-5
ZFIN:ZDB-MRPHLNO-061130-6

P

From ZFIN

GO:0043027

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

ZFIN:ZDB-PUB-070303-43
PMID:17332774[1]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-061130-3
ZFIN:ZDB-MRPHLNO-061130-4
ZFIN:ZDB-MRPHLNO-061130-5
ZFIN:ZDB-MRPHLNO-061130-6

F

From ZFIN

GO:0043548

phosphatidylinositol 3-kinase binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016246

F

From ZFIN

GO:0043560

insulin receptor substrate binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016246

F

From ZFIN

GO:0046777

protein autophosphorylation

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR016246

P

From ZFIN

GO:0048009

insulin-like growth factor receptor signaling pathway

ZFIN:ZDB-PUB-020429-3
PMID:11956169[2]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0048752

semicircular canal morphogenesis

ZFIN:ZDB-PUB-060531-4
PMID:16705083[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-061130-5
ZFIN:ZDB-MRPHLNO-061130-6

P

From ZFIN


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Schlueter PJ et al. (2007) Insulin-like growth factor signaling regulates zebrafish embryonic growth and development by promoting cell survival and cell cycle progression. Cell Death Differ 14: 1095-105 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Maures T et al. (2002) Structural, biochemical, and expression analysis of two distinct insulin-like growth factor I receptors and their ligands in zebrafish. Endocrinology 143: 1858-71 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Schlueter PJ et al. (2006) Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors. FASEB J 20: 1230-2 PubMed GONUTS page
  4. Schlueter PJ et al. (2007) Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survival. Dev Biol 305: 377-87 PubMed GONUTS page
  5. Sang X et al. (2008) Paracrine insulin-like growth factor signaling influences primordial germ cell migration: in vivo evidence from the zebrafish model. Endocrinology 149: 5035-42 PubMed GONUTS page
  6. Chablais F & Jazwinska A (2010) IGF signaling between blastema and wound epidermis is required for fin regeneration. Development 137: 871-9 PubMed GONUTS page
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