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ZFIN:foxh1

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Contents

Species (Taxon ID) Danio rerio (zebrafish) (taxon:7955)
Gene Name(s) foxh1
Protein Name(s) forkhead box H1,
External Links
ZFIN ZDB-GENE-000616-15

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001071

nucleic acid binding transcription factor activity

ZFIN:ZDB-PUB-070303-21
PMID:17306248[1]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-070529-5

F

From ZFIN

GO:0001071

nucleic acid binding transcription factor activity

ZFIN:ZDB-PUB-070303-21
PMID:17306248[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

F

From ZFIN

GO:0001568

blood vessel development

ZFIN:ZDB-PUB-070303-21
PMID:17306248[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

From ZFIN

GO:0001706

endoderm formation

ZFIN:ZDB-PUB-001003-1
PMID:10996071[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

From ZFIN

GO:0001707

mesoderm formation

ZFIN:ZDB-PUB-001003-1
PMID:10996071[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

From ZFIN

GO:0001947

heart looping

ZFIN:ZDB-PUB-971203-9
PMID:9334285[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1029

P

From ZFIN

GO:0003143

embryonic heart tube morphogenesis

ZFIN:ZDB-PUB-971203-9
PMID:9334285[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1029

P

From ZFIN

GO:0003677

DNA binding

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

From ZFIN

GO:0003690

double-stranded DNA binding

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR11829_AN0

F

From ZFIN

GO:0003700

sequence-specific DNA binding transcription factor activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

F

From ZFIN

GO:0003700

sequence-specific DNA binding transcription factor activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR018122

F

From ZFIN

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR11829_AN0

F

From ZFIN

GO:0005634

nucleus

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

From ZFIN

GO:0005634

nucleus

ZFIN:ZDB-PUB-070303-21
PMID:17306248[1]

IC: Inferred by Curator

GO:0043565

C

From ZFIN

GO:0006351

transcription, DNA-dependent

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From ZFIN

GO:0006355

regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

From ZFIN

GO:0006355

regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

P

From ZFIN

GO:0006355

regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR018122

P

From ZFIN

GO:0006355

regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-070303-21
PMID:17306248[1]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-070529-5

P

From ZFIN

GO:0007179

transforming growth factor beta receptor signaling pathway

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR11829_AN592

P

From ZFIN

GO:0007368

determination of left/right symmetry

ZFIN:ZDB-PUB-000824-14
PMID:10903181[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1029

P

From ZFIN

GO:0007368

determination of left/right symmetry

ZFIN:ZDB-PUB-971203-9
PMID:9334285[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1029

P

From ZFIN

GO:0008134

transcription factor binding

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR11829_AN0

F

From ZFIN

GO:0008301

DNA binding, bending

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR11829_AN1

F

From ZFIN

GO:0009953

dorsal/ventral pattern formation

ZFIN:ZDB-PUB-001003-1
PMID:10996071[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

From ZFIN

GO:0010159

specification of organ position

ZFIN:ZDB-PUB-000824-14
PMID:10903181[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1029

P

From ZFIN

GO:0010468

regulation of gene expression

ZFIN:ZDB-PUB-001003-1
PMID:10996071[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

From ZFIN

GO:0014028

notochord formation

ZFIN:ZDB-PUB-110609-58
PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-2

P

From ZFIN

GO:0014028

notochord formation

ZFIN:ZDB-PUB-110609-58
PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-3

P

From ZFIN

GO:0019904

protein domain specific binding

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR11829_AN592

F

From ZFIN

GO:0021501

prechordal plate formation

ZFIN:ZDB-PUB-110609-58
PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-2

P

From ZFIN

GO:0021508

floor plate formation

ZFIN:ZDB-PUB-000309-33
PMID:10694427[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1029

P

From ZFIN

GO:0032444

activin responsive factor complex

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR11829_AN592

C

From ZFIN

GO:0032525

somite rostral/caudal axis specification

ZFIN:ZDB-PUB-110609-58
PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-2

P

From ZFIN

GO:0035054

embryonic heart tube anterior/posterior pattern specification

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR11829_AN592

P

From ZFIN

GO:0042074

cell migration involved in gastrulation

ZFIN:ZDB-PUB-070907-3
PMID:17719025[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080110-1

P

From ZFIN

GO:0042074

cell migration involved in gastrulation

ZFIN:ZDB-PUB-070907-3
PMID:17719025[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080110-2

P

From ZFIN

GO:0043565

sequence-specific DNA binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

F

From ZFIN

GO:0043565

sequence-specific DNA binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR018122

F

From ZFIN

GO:0043565

sequence-specific DNA binding

ZFIN:ZDB-PUB-070303-21
PMID:17306248[1]

IDA: Inferred from Direct Assay

F

From ZFIN

GO:0043565

sequence-specific DNA binding

ZFIN:ZDB-PUB-110609-58
PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-3

F

From ZFIN

GO:0045892

negative regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-070303-21
PMID:17306248[1]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0045892

negative regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-070303-21
PMID:17306248[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

From ZFIN

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR11829_AN592

P

From ZFIN

GO:0046332

SMAD binding

ZFIN:ZDB-PUB-110609-58
PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-2

F

From ZFIN

GO:0048318

axial mesoderm development

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR11829_AN592

P

From ZFIN

GO:0048319

axial mesoderm morphogenesis

ZFIN:ZDB-PUB-110609-58
PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-3

P

From ZFIN

GO:0048327

axial mesodermal cell fate specification

ZFIN:ZDB-PUB-110609-58
PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-2

P

From ZFIN

GO:0048382

mesendoderm development

ZFIN:ZDB-PUB-110609-58
PMID:21637786[5]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-001228-1
ZFIN:ZDB-GENO-111207-2

P

From ZFIN

GO:0051090

regulation of sequence-specific DNA binding transcription factor activity

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR11829_AN0

P

From ZFIN

GO:0060063

Spemann organizer formation at the embryonic shield

ZFIN:ZDB-PUB-001003-1
PMID:10996071[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

From ZFIN

GO:0060070

canonical Wnt receptor signaling pathway

ZFIN:ZDB-PUB-001003-1
PMID:10996071[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070529-4

P

From ZFIN

GO:0060971

embryonic heart tube left/right pattern formation

ZFIN:ZDB-PUB-110609-58
PMID:21637786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-111207-2

P

From ZFIN

GO:0070412

R-SMAD binding

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR11829_AN592

F

From ZFIN

GO:2000223

regulation of BMP signaling pathway involved in heart jogging

ZFIN:ZDB-PUB-971203-9
PMID:9334285[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1029

P

From ZFIN


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Choi J et al. (2007) FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish. Dev Biol 304: 735-44 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Pogoda HM et al. (2000) The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formation. Curr Biol 10: 1041-9 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Chen JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124: 4373-82 PubMed GONUTS page
  4. 4.0 4.1 Bisgrove BW et al. (2000) Multiple pathways in the midline regulate concordant brain, heart and gut left-right asymmetry. Development 127: 3567-79 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 5.9 Slagle CE et al. (2011) Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin. PLoS Genet 7: e1002072 PubMed GONUTS page
  6. Odenthal J et al. (2000) Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Dev Biol 219: 350-63 PubMed GONUTS page
  7. 7.0 7.1 Pei W et al. (2007) An early requirement for maternal FoxH1 during zebrafish gastrulation. Dev Biol 310: 10-22 PubMed GONUTS page
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