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ZFIN:cyp1a

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Contents

Species (Taxon ID) Danio rerio (zebrafish) (taxon:7955)
Gene Name(s) cyp1a
Protein Name(s) cytochrome P450, family 1, subfamily A,
External Links
ZFIN ZDB-GENE-011219-1

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004497

monooxygenase activity

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0503

F

From ZFIN

GO:0005506

iron ion binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001128

F

From ZFIN

GO:0005506

iron ion binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR002401

F

From ZFIN

GO:0005506

iron ion binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR008066

F

From ZFIN

GO:0006725

cellular aromatic compound metabolic process

ZFIN:ZDB-PUB-060921-3
PMID:16963132[1]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0009055

electron carrier activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001128

F

From ZFIN

GO:0009410

response to xenobiotic stimulus

ZFIN:ZDB-PUB-070427-14
PMID:17433458[2]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0009410

response to xenobiotic stimulus

ZFIN:ZDB-PUB-070907-5
PMID:17720151[3]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0009410

response to xenobiotic stimulus

ZFIN:ZDB-PUB-081105-3
PMID:18973944[4]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0016491

oxidoreductase activity

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

F

From ZFIN

GO:0016705

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001128

F

From ZFIN

GO:0016705

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR002401

F

From ZFIN

GO:0016705

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR017972

F

From ZFIN

GO:0016712

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR008066

F

From ZFIN

GO:0020037

heme binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001128

F

From ZFIN

GO:0020037

heme binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR002401

F

From ZFIN

GO:0020037

heme binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR008066

F

From ZFIN

GO:0042221

response to chemical stimulus

ZFIN:ZDB-PUB-050831-4
PMID:16122694[5]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0042221

response to chemical stimulus

ZFIN:ZDB-PUB-051214-14
PMID:16330359[6]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0042221

response to chemical stimulus

ZFIN:ZDB-PUB-051214-14
PMID:16330359[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050604-1
ZFIN:ZDB-MRPHLNO-060104-4

P

From ZFIN

GO:0042221

response to chemical stimulus

ZFIN:ZDB-PUB-051214-14
PMID:16330359[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050604-1

P

From ZFIN

GO:0042221

response to chemical stimulus

ZFIN:ZDB-PUB-060517-22
PMID:16687390[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060104-3

P

From ZFIN

GO:0042221

response to chemical stimulus

ZFIN:ZDB-PUB-080714-17
PMID:18618001[8]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0046872

metal ion binding

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From ZFIN

GO:0055114

oxidation-reduction process

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

P

From ZFIN

GO:0055114

oxidation-reduction process

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001128

P

From ZFIN

GO:0055114

oxidation-reduction process

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR002401

P

From ZFIN

GO:0055114

oxidation-reduction process

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR008066

P

From ZFIN

GO:0055114

oxidation-reduction process

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR017972

P

From ZFIN


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Miranda CL et al. (2006) Comparative in vitro metabolism of benzo[a]pyrene by recombinant zebrafish CYP1A and liver microsomes from beta-naphthoflavone-treated rainbow trout. Aquat Toxicol 80: 101-8 PubMed GONUTS page
  2. Alsop D et al. (2007) The effects of copper and benzo[a]pyrene on retinoids and reproduction in zebrafish. Aquat Toxicol 82: 281-95 PubMed GONUTS page
  3. Zeruth G & Pollenz RS (2007) Functional analysis of cis-regulatory regions within the dioxin-inducible CYP1A promoter/enhancer region from zebrafish (Danio rerio). Chem Biol Interact 170: 100-13 PubMed GONUTS page
  4. Na YR et al. (2009) Protective effects of vitamin E against 3,3',4,4',5-pentachlorobiphenyl (PCB126) induced toxicity in zebrafish embryos. Ecotoxicol Environ Saf 72: 714-9 PubMed GONUTS page
  5. Evans BR et al. (2005) Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: structure, function, evolution, and AHR-dependent regulation in vivo. Arch Biochem Biophys 441: 151-67 PubMed GONUTS page
  6. 6.0 6.1 6.2 Incardona JP et al. (2005) Aryl hydrocarbon receptor-independent toxicity of weathered crude oil during fish development. Environ Health Perspect 113: 1755-62 PubMed GONUTS page
  7. Billiard SM et al. (2006) The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. Toxicol Sci 92: 526-36 PubMed GONUTS page
  8. Lam SH et al. (2008) Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. PLoS Genet 4: e1000121 PubMed GONUTS page
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