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ZFIN:atp1a1

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Contents

Species (Taxon ID) Danio rerio (zebrafish) (taxon:7955)
Gene Name(s) atp1a1
Protein Name(s) ATPase, Na+/K+ transporting, alpha 1 polypeptide,
External Links
ZFIN ZDB-GENE-001212-1

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From ZFIN

GO:0000166

nucleotide binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR008250

F

From ZFIN

GO:0003824

catalytic activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR005834

F

From ZFIN

GO:0005391

sodium:potassium-exchanging ATPase activity

ZFIN:ZDB-PUB-031111-8
PMID:14602677[1]

IMP: Inferred from Mutant Phenotype

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001757

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR005775

F

From ZFIN

GO:0005887

integral to plasma membrane

ZFIN:ZDB-PUB-040810-6
PMID:15297381[2]

NAS: Non-traceable Author Statement

C

From ZFIN

GO:0006754

ATP biosynthetic process

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR005775

P

From ZFIN

GO:0006754

ATP biosynthetic process

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR006069

P

From ZFIN

GO:0006810

transport

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

From ZFIN

GO:0006811

ion transport

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0406

P

From ZFIN

GO:0006812

cation transport

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001757

P

From ZFIN

GO:0007368

determination of left/right symmetry

ZFIN:ZDB-PUB-060424-7
PMID:16628609[3]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

GO:0007368

determination of left/right symmetry

ZFIN:ZDB-PUB-060424-7
PMID:16628609[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-060308-1

P

From ZFIN

GO:0007420

brain development

ZFIN:ZDB-PUB-031111-8
PMID:14602677[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-031230-1

P

From ZFIN

GO:0007420

brain development

ZFIN:ZDB-PUB-050328-1
PMID:15788456[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-050707-1

P

From ZFIN

GO:0008152

metabolic process

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR005834

P

From ZFIN

GO:0010172

embryonic body morphogenesis

ZFIN:ZDB-PUB-031111-8
PMID:14602677[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-031230-1

P

From ZFIN

GO:0015077

monovalent inorganic cation transmembrane transporter activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR005775

F

From ZFIN

GO:0015662

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001757

F

From ZFIN

GO:0015662

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR006069

F

From ZFIN

GO:0015672

monovalent inorganic cation transport

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR005775

P

From ZFIN

GO:0016020

membrane

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From ZFIN

GO:0016020

membrane

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001757

C

From ZFIN

GO:0016020

membrane

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR006069

C

From ZFIN

GO:0016021

integral to membrane

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From ZFIN

GO:0016021

integral to membrane

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR005775

C

From ZFIN

GO:0016021

integral to membrane

ZFIN:ZDB-PUB-031111-8
PMID:14602677[1]

NAS: Non-traceable Author Statement

C

From ZFIN

GO:0016021

integral to membrane

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q92123

C

From ZFIN

GO:0016787

hydrolase activity

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

From ZFIN

GO:0016820

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR005775

F

From ZFIN

GO:0016820

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR023306

F

From ZFIN

GO:0030916

otic vesicle formation

ZFIN:ZDB-PUB-060403-5
PMID:16566913[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060215-3

P

From ZFIN

GO:0030917

midbrain-hindbrain boundary development

ZFIN:ZDB-PUB-060403-5
PMID:16566913[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060215-3

P

From ZFIN

GO:0035050

embryonic heart tube development

ZFIN:ZDB-PUB-031111-8
PMID:14602677[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-031230-1

P

From ZFIN

GO:0035050

embryonic heart tube development

ZFIN:ZDB-PUB-070210-8
PMID:17227894[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-031230-1

P

From ZFIN

GO:0035051

cardiac cell differentiation

ZFIN:ZDB-PUB-031111-8
PMID:14602677[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-031230-1

P

From ZFIN

GO:0035051

cardiac cell differentiation

ZFIN:ZDB-PUB-040810-6
PMID:15297381[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-041105-1

P

From ZFIN

GO:0046872

metal ion binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR008250

F

From ZFIN

GO:0048840

otolith development

ZFIN:ZDB-PUB-060403-5
PMID:16566913[5]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-060215-3
ZFIN:ZDB-MRPHLNO-060626-8

P

From ZFIN

GO:0048840

otolith development

ZFIN:ZDB-PUB-060403-5
PMID:16566913[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060215-3

P

From ZFIN

GO:0048840

otolith development

ZFIN:ZDB-PUB-060403-5
PMID:16566913[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060622-1

P

From ZFIN

GO:0071599

otic vesicle development

ZFIN:ZDB-PUB-970210-23
PMID:9007247[7]

IMP: Inferred from Mutant Phenotype

P

From ZFIN


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 1.5 Shu X et al. (2003) Na,K-ATPase is essential for embryonic heart development in the zebrafish. Development 130: 6165-73 PubMed GONUTS page
  2. 2.0 2.1 Yuan S & Joseph EM (2004) The small heart mutation reveals novel roles of Na+/K+-ATPase in maintaining ventricular cardiomyocyte morphology and viability in zebrafish. Circ Res 95: 595-603 PubMed GONUTS page
  3. 3.0 3.1 Ellertsdottir E et al. (2006) A mutation in the zebrafish Na,K-ATPase subunit atp1a1a.1 provides genetic evidence that the sodium potassium pump contributes to left-right asymmetry downstream or in parallel to nodal flow. Dev Dyn 235: 1794-808 PubMed GONUTS page
  4. Lowery LA & Sive H (2005) Initial formation of zebrafish brain ventricles occurs independently of circulation and requires the nagie oko and snakehead/atp1a1a.1 gene products. Development 132: 2057-67 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 Blasiole B et al. (2006) Separate Na,K-ATPase genes are required for otolith formation and semicircular canal development in zebrafish. Dev Biol 294: 148-60 PubMed GONUTS page
  6. Cibrián-Uhalte E et al. (2007) Involvement of zebrafish Na+,K+ ATPase in myocardial cell junction maintenance. J Cell Biol 176: 223-30 PubMed GONUTS page
  7. Malicki J et al. (1996) Mutations affecting development of the zebrafish ear. Development 123: 275-83 PubMed GONUTS page
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