Ambox notice.png

GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.

You can help reduce stress on the server by:

  1. not reloading pages frequently - this just adds
  2. opening links in new windows (so you can read the old page)

YERPE:YOPE

From GONUTS
Jump to: navigation, search

Contents

Species (Taxon ID) Yersinia pestis. (taxon:632)
Gene Name(s) yopE ( synonyms: yop25 )
Protein Name(s)
  • Outer membrane virulence protein yopE
External Links
UniProt Identifier YOPE_YERPE
UniProt Accessions P31493,
EMBL M34279, AF074612, AF053946, AL117189, AE017043,
PIR T43605,
RefSeq NP_395143.1, NP_857762.1, NP_857967.1, NP_995401.1,
PDB 1HY5,
Pfam PF03545, PF09020,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0009279

cell outer membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0040

C

GO:0009405

pathogenesis

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0843

P

GO:0050765

negative regulation of phagocytosis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015110

P

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003537

C

GO:0005096

GTPase activator activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003537

F

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015110

C

GO:0005886

plasma membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

GO:0009279

cell outer membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0998

C

GO:0005096

GTPase activator activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003537

F

GO:0050765

negative regulation of phagocytosis

PMID:20148901[1]

IMP: Inferred from Mutant Phenotype

P

In table 1, shows mutant phenotypes with decreased negative regulation of phagocytosis.

complete

GO:0005886

plasma membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

GO:0009405

pathogenesis

PMID:15322017[2]

IMP: Inferred from Mutant Phenotype

P

Figure 3 shows colonization and persistance decreased by half in mice using a YOPE knockout mutant.

complete

GO:0009279

cell outer membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0998

C

GO:0009279

cell outer membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0040

C

GO:0009405

pathogenesis

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0843

P

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003537

C

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015110

C

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

GO:0043547

positive regulation of GTPase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003537

P

GO:0050765

negative regulation of phagocytosis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015110

P


Notes

References

See Help:References for how to manage references in GONUTS.

  1. Songsungthong W et al. (2010) ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice. Cell Microbiol 12: 988-1001 PubMed GONUTS page
  2. Trülzsch K et al. (2004) Contribution of the major secreted yops of Yersinia enterocolitica O:8 to pathogenicity in the mouse infection model. Infect Immun 72: 5227-34 PubMed GONUTS page
Personal tools
Namespaces
Variants
Actions
Navigation
Cacao
Journal Clubs
page contributors
Toolbox