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YEAST:VAC14

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Contents

Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (taxon:559292)
Gene Name(s) VAC14 ( synonyms: SVP2 )
Protein Name(s)
  • Vacuole morphology and inheritance protein 14
  • Swollen vacuole phenotype 2 protein
External Links
UniProt Identifier VAC14_YEAST
UniProt Accessions Q06708, D6VZ21,
EMBL U19104, BK006945,
PIR S51473,
RefSeq NP_013490.1,
IntAct Q06708,
Pfam PF02985, PF11916,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000306

extrinsic to vacuolar membrane

IDA: Inferred from Direct Assay

C

Source: SGD

GO:0000329

fungal-type vacuole membrane

IDA: Inferred from Direct Assay

C

Source: SGD

GO:0070772

PAS complex

IDA: Inferred from Direct Assay

C

Source: SGD

GO:0030674

protein binding, bridging

IDA: Inferred from Direct Assay

F

Source: SGD

GO:0006661

phosphatidylinositol biosynthetic process

IGI: Inferred from Genetic Interaction

P

Source: SGD

GO:0033674

positive regulation of kinase activity

IGI: Inferred from Genetic Interaction

P

Source: SGD

GO:0015031

protein transport

IEA: Inferred from Electronic Annotation

P

Source: UniProtKB-KW

GO:0000306

extrinsic to vacuolar membrane

PMID:11889142[1]

IDA: Inferred from Direct Assay

C

GO:0000329

fungal-type vacuole membrane

PMID:11889142[1]

IDA: Inferred from Direct Assay

C

GO:0000329

fungal-type vacuole membrane

PMID:14528018[2]

IDA: Inferred from Direct Assay

C

GO:0005488

binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011989

F

GO:0005488

binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016024

F

GO:0005515

protein binding

PMID:11283351[3]

IPI: Inferred from Physical Interaction

UniProtKB:P10849

F

GO:0005515

protein binding

PMID:11283351[3]

IPI: Inferred from Physical Interaction

UniProtKB:P23639

F

GO:0005515

protein binding

PMID:11283351[3]

IPI: Inferred from Physical Interaction

UniProtKB:P53959

F

GO:0005515

protein binding

PMID:14528018[2]

IPI: Inferred from Physical Interaction

UniProtKB:P42837

F

GO:0005515

protein binding

PMID:18467557[4]

IPI: Inferred from Physical Interaction

UniProtKB:P23255

F

GO:0005515

protein binding

PMID:18467557[4]

IPI: Inferred from Physical Interaction

UniProtKB:P38800

F

GO:0005515

protein binding

PMID:18467557[4]

IPI: Inferred from Physical Interaction

UniProtKB:P43601

F

GO:0005515

protein binding

PMID:18719252[5]

IPI: Inferred from Physical Interaction

UniProtKB:P38972

F

GO:0005515

protein binding

PMID:20489023[6]

IPI: Inferred from Physical Interaction

UniProtKB:P34756

F

GO:0005773

vacuole

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0926

C

GO:0005774

vacuolar membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0271

C

GO:0006661

phosphatidylinositol biosynthetic process

PMID:11889142[1]

IGI: Inferred from Genetic Interaction

SGD:S000001915

P

GO:0006661

phosphatidylinositol biosynthetic process

PMID:11889142[1]

IMP: Inferred from Mutant Phenotype

P

GO:0006810

transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

GO:0015031

protein transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0653

P

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

GO:0030674

protein binding, bridging

PMID:19037259[7]

IMP: Inferred from Mutant Phenotype

F

GO:0033674

positive regulation of kinase activity

PMID:11889142[1]

IGI: Inferred from Genetic Interaction

SGD:S000001915

P

GO:0033674

positive regulation of kinase activity

PMID:11889142[1]

IMP: Inferred from Mutant Phenotype

P

GO:0070772

PAS complex

PMID:19037259[7]

IDA: Inferred from Direct Assay

C


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Bonangelino CJ et al. (2002) Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. J Cell Biol 156: 1015-28 PubMed GONUTS page
  2. 2.0 2.1 Rudge SA et al. (2004) Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Mol Biol Cell 15: 24-36 PubMed GONUTS page
  3. 3.0 3.1 3.2 Ito T et al. (2001) A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A 98: 4569-74 PubMed GONUTS page
  4. 4.0 4.1 4.2 Tarassov K et al. (2008) An in vivo map of the yeast protein interactome. Science 320: 1465-70 PubMed GONUTS page
  5. Yu H et al. (2008) High-quality binary protein interaction map of the yeast interactome network. Science 322: 104-10 PubMed GONUTS page
  6. Breitkreutz A et al. (2010) A global protein kinase and phosphatase interaction network in yeast. Science 328: 1043-6 PubMed GONUTS page
  7. 7.0 7.1 Jin N et al. (2008) VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J 27: 3221-34 PubMed GONUTS page
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