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YEAST:SNF1
Contents |
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | SNF1 (synonyms: CAT1, CCR1, GLC2, PAS14) | |
| Protein Name(s) | Carbon catabolite-derepressing protein kinase | |
| External Links | ||
| UniProt | P06782 | |
| EMBL | M13971 U33050 BK006938 | |
| PIR | A26030 | |
| RefSeq | NP_010765.1 | |
| PDB | 2FH9 2QLV 3DAE 3HYH 3MN3 3T4N 3TDH 3TE5 | |
| PDBsum | 2FH9 2QLV 3DAE 3HYH 3MN3 3T4N 3TDH 3TE5 | |
| ProteinModelPortal | P06782 | |
| SMR | P06782 | |
| DIP | DIP-18N | |
| IntAct | P06782 | |
| MINT | MINT-364314 | |
| STRING | P06782 | |
| PeptideAtlas | P06782 | |
| EnsemblFungi | YDR477W | |
| GeneID | 852088 | |
| KEGG | sce:YDR477W | |
| NMPDR | fig|4932.3.peg.1538 | |
| CYGD | YDR477w | |
| SGD | S000002885 | |
| eggNOG | fuNOG05716 | |
| GeneTree | EFGT00070000008711 | |
| HOGENOM | HBG755340 | |
| OMA | SKIGILP | |
| OrthoDB | EOG4Q5CXQ | |
| BRENDA | 2.7.11.1 | |
| NextBio | 970409 | |
| ArrayExpress | P06782 | |
| Genevestigator | P06782 | |
| GermOnline | YDR477W | |
| GO | GO:0031588 GO:0000324 GO:0005739 GO:0005641 GO:0031965 GO:0004679 GO:0005524 GO:0005515 GO:0042710 GO:0005975 GO:0007155 GO:0006995 GO:0001403 GO:0017148 GO:0045722 GO:0007124 GO:0001302 GO:0007165 | |
| InterPro | IPR011009 IPR000719 IPR017441 IPR017442 IPR008271 IPR002290 IPR013896 | |
| KO | K12761 | |
| Pfam | PF00069 PF08587 | |
| SMART | SM00220 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0000324 |
fungal-type vacuole |
IPI: Inferred from Physical Interaction |
|
C |
Seeded From UniProt |
|||
| GO:0001302 |
replicative cell aging |
IGI: Inferred from Genetic Interaction |
SGD:S000002830 |
P |
Seeded From UniProt |
|||
| GO:0001302 |
replicative cell aging |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0001403 |
invasive growth in response to glucose limitation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0001403 |
invasive growth in response to glucose limitation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0004672 |
protein kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004672 |
protein kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004679 |
AMP-activated protein kinase activity |
IMP: Inferred from Mutant Phenotype |
|
F |
Seeded From UniProt |
|||
| GO:0004679 |
AMP-activated protein kinase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0004679 |
AMP-activated protein kinase activity |
IMP: Inferred from Mutant Phenotype |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IPI: Inferred from Physical Interaction |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005641 |
nuclear envelope lumen |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IPI: Inferred from Physical Interaction |
|
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005739 |
mitochondrion |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005739 |
mitochondrion |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005975 |
carbohydrate metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006109 |
regulation of carbohydrate metabolic process |
IGI: Inferred from Genetic Interaction |
|
P |
Seeded From UniProt |
|||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0006995 |
cellular response to nitrogen starvation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0007124 |
pseudohyphal growth |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0007155 |
cell adhesion |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0007165 |
signal transduction |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016301 |
kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016310 |
phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0017148 |
negative regulation of translation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0031588 |
AMP-activated protein kinase complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0031588 |
AMP-activated protein kinase complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0031588 |
AMP-activated protein kinase complex |
IPI: Inferred from Physical Interaction |
SGD:S000003083 |
C |
Seeded From UniProt |
|||
| GO:0031965 |
nuclear membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0182 |
C |
Seeded From UniProt |
|||
| GO:0042710 |
biofilm formation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045722 |
positive regulation of gluconeogenesis |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045722 |
positive regulation of gluconeogenesis |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045722 |
positive regulation of gluconeogenesis |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0009758 |
carbohydrate utilization |
IMP: Inferred from Mutant Phenotype |
P |
Table 4 |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Vincent O et al. (2001) Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism. Genes Dev 15: 1104-14 PubMed GONUTS page
- ↑ 2.0 2.1 Ashrafi K et al. (2000) Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. Genes Dev 14: 1872-85 PubMed GONUTS page
- ↑ Cullen PJ & Sprague GF Jr (2000) Glucose depletion causes haploid invasive growth in yeast. Proc Natl Acad Sci U S A 97: 13619-24 PubMed GONUTS page
- ↑ 4.0 4.1 Vyas VK et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23: 1341-8 PubMed GONUTS page
- ↑ 5.0 5.1 McCartney RR & Schmidt MC (2001) Regulation of Snf1 kinase. Activation requires phosphorylation of threonine 210 by an upstream kinase as well as a distinct step mediated by the Snf4 subunit. J Biol Chem 276: 36460-6 PubMed GONUTS page
- ↑ Celenza JL & Carlson M (1989) Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 protein. Mol Cell Biol 9: 5034-44 PubMed GONUTS page
- ↑ Woods A et al. (1994) Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. J Biol Chem 269: 19509-15 PubMed GONUTS page
- ↑ Ito T et al. (2001) A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A 98: 4569-74 PubMed GONUTS page
- ↑ Gavin AC et al. (2002) Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 415: 141-7 PubMed GONUTS page
- ↑ Metz J et al. (2006) The yeast Arr4p ATPase binds the chloride transporter Gef1p when copper is available in the cytosol. J Biol Chem 281: 410-7 PubMed GONUTS page
- ↑ 11.0 11.1 Breitkreutz A et al. (2010) A global protein kinase and phosphatase interaction network in yeast. Science 328: 1043-6 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Sarma NJ et al. (2007) Glucose-responsive regulators of gene expression in Saccharomyces cerevisiae function at the nuclear periphery via a reverse recruitment mechanism. Genetics 175: 1127-35 PubMed GONUTS page
- ↑ Sickmann A et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100: 13207-12 PubMed GONUTS page
- ↑ Reinders J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5: 1543-54 PubMed GONUTS page
- ↑ Young ET et al. (2002) Snf1 protein kinase regulates Adr1 binding to chromatin but not transcription activation. J Biol Chem 277: 38095-103 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 Kuchin S et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22: 3994-4000 PubMed GONUTS page
- ↑ Carlson M (1999) Glucose repression in yeast. Curr Opin Microbiol 2: 202-7 PubMed GONUTS page
- ↑ Shirra MK et al. (2008) A chemical genomics study identifies Snf1 as a repressor of GCN4 translation. J Biol Chem 283: 35889-98 PubMed GONUTS page
- ↑ Nath N et al. (2002) Purification and characterization of Snf1 kinase complexes containing a defined Beta subunit composition. J Biol Chem 277: 50403-8 PubMed GONUTS page
- ↑ 20.0 20.1 Celenza JL et al. (1989) Molecular analysis of the SNF4 gene of Saccharomyces cerevisiae: evidence for physical association of the SNF4 protein with the SNF1 protein kinase. Mol Cell Biol 9: 5045-54 PubMed GONUTS page
- ↑ Lesage P et al. (1996) Yeast SNF1 protein kinase interacts with SIP4, a C6 zinc cluster transcriptional activator: a new role for SNF1 in the glucose response. Mol Cell Biol 16: 1921-8 PubMed GONUTS page
- ↑ Rahner A et al. (1996) Dual influence of the yeast Cat1p (Snf1p) protein kinase on carbon source-dependent transcriptional activation of gluconeogenic genes by the regulatory gene CAT8. Nucleic Acids Res 24: 2331-7 PubMed GONUTS page
- ↑ Randez-Gil F et al. (1997) Glucose derepression of gluconeogenic enzymes in Saccharomyces cerevisiae correlates with phosphorylation of the gene activator Cat8p. Mol Cell Biol 17: 2502-10 PubMed GONUTS page
- ↑ Carlson M et al. (1981) Mutants of yeast defective in sucrose utilization. Genetics 98: 25-40 PubMed GONUTS page
