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YEAST:MRE11
Contents |
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). ([1]) | |
| Gene Name(s) | MRE11 | |
| Protein Name(s) | Double-strand break repair protein MRE11 | |
| External Links | ||
| EMBL | D11463 Z49939 U60829 BK006946 | |
| PIR | S57592 | |
| RefSeq | NP_013951.1 | |
| ProteinModelPortal | P32829 | |
| SMR | P32829 | |
| DIP | DIP-1313N | |
| IntAct | P32829 | |
| MINT | MINT-388080 | |
| STRING | P32829 | |
| EnsemblFungi | YMR224C | |
| GeneID | 855264 | |
| KEGG | sce:YMR224C | |
| NMPDR | fig|4932.3.peg.5004 | |
| CYGD | YMR224c | |
| SGD | S000004837 | |
| eggNOG | fuNOG05758 | |
| GeneTree | EFGT00050000003116 | |
| HOGENOM | HBG596413 | |
| OMA | QVENPRR | |
| OrthoDB | EOG4P2T9Q | |
| PhylomeDB | P32829 | |
| Reactome | REACT_27164 | |
| NextBio | 978864 | |
| ArrayExpress | P32829 | |
| Genevestigator | P32829 | |
| GermOnline | YMR224C | |
| GO | GO:0005739 GO:0030870 GO:0008408 GO:0003691 GO:0004520 GO:0051880 GO:0030145 GO:0032947 GO:0043047 GO:0030437 GO:0006284 GO:0000727 GO:0006303 GO:0042138 GO:0000706 GO:0051037 | |
| InterPro | IPR003701 IPR004843 IPR007281 | |
| PANTHER | PTHR10139 | |
| Pfam | PF00149 PF04152 | |
| PIRSF | PIRSF000882 | |
| TIGRFAMs | TIGR00583 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000706 |
meiotic DNA double-strand break processing |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0000727 |
double-strand break repair via break-induced replication |
IGI: Inferred from Genetic Interaction |
SGD:S000004897 |
P |
Seeded From UniProt |
|||
| GO:0000727 |
double-strand break repair via break-induced replication |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0003691 |
double-stranded telomeric DNA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0004518 |
nuclease activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004519 |
endonuclease activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004519 |
endonuclease activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004519 |
endonuclease activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0004520 |
endodeoxyribonuclease activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0004527 |
exonuclease activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004527 |
exonuclease activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_27164 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005739 |
mitochondrion |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005739 |
mitochondrion |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006259 |
DNA metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006281 |
DNA repair |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006281 |
DNA repair |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0006284 |
base-excision repair |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0006302 |
double-strand break repair |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006303 |
double-strand break repair via nonhomologous end joining |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0006974 |
response to DNA damage stimulus |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007126 |
meiosis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008296 |
3'-5'-exodeoxyribonuclease activity |
Reactome:REACT_27164 |
EXP: Inferred from Experiment |
|
F |
Seeded From UniProt |
||
| GO:0008408 |
3'-5' exonuclease activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0030145 |
manganese ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0030437 |
ascospore formation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0030870 |
Mre11 complex |
IPI: Inferred from Physical Interaction |
|
C |
Seeded From UniProt |
|||
| GO:0032947 |
protein complex scaffold |
IMP: Inferred from Mutant Phenotype |
|
F |
Seeded From UniProt |
|||
| GO:0042138 |
meiotic DNA double-strand break formation |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0042162 |
telomeric DNA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0042162 |
telomeric DNA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0043047 |
single-stranded telomeric DNA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0051037 |
regulation of transcription during meiosis |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0051880 |
G-quadruplex DNA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0004017 |
adenylate kinase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0007126 |
meiosis |
IMP: Inferred from Mutant Phenotype |
P |
Figure 8 |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Roeder GS (1997) Meiotic chromosomes: it takes two to tango. Genes Dev 11: 2600-21 PubMed GONUTS page
- ↑ 2.0 2.1 Krishna S et al. (2007) Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication. DNA Repair (Amst) 6: 797-808 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Ghosal G & Muniyappa K (2007) The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity. J Mol Biol 372: 864-82 PubMed GONUTS page
- ↑ 4.0 4.1 Moreau S et al. (1999) The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol Cell Biol 19: 556-66 PubMed GONUTS page
- ↑ 5.0 5.1 Ghosal G & Muniyappa K (2005) Saccharomyces cerevisiae Mre11 is a high-affinity G4 DNA-binding protein and a G-rich DNA-specific endonuclease: implications for replication of telomeric DNA. Nucleic Acids Res 33: 4692-703 PubMed GONUTS page
- ↑ 6.0 6.1 Ho Y et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 415: 180-3 PubMed GONUTS page
- ↑ Tsukamoto Y et al. (2005) Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination. Mol Biol Cell 16: 597-608 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Usui T et al. (1998) Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 95: 705-16 PubMed GONUTS page
- ↑ Sickmann A et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100: 13207-12 PubMed GONUTS page
- ↑ Reinders J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5: 1543-54 PubMed GONUTS page
- ↑ Johzuka K & Ogawa H (1995) Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae. Genetics 139: 1521-32 PubMed GONUTS page
- ↑ Steininger S et al. (2010) A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair. Nucleic Acids Res 38: 1853-65 PubMed GONUTS page
- ↑ Wilson TE (2002) A genomics-based screen for yeast mutants with an altered recombination/end-joining repair ratio. Genetics 162: 677-88 PubMed GONUTS page
- ↑ Trujillo KM & Sung P (2001) DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex. J Biol Chem 276: 35458-64 PubMed GONUTS page
- ↑ 15.0 15.1 Kugou K et al. (2007) Mre11 mediates gene regulation in yeast spore development. Genes Genet Syst 82: 21-33 PubMed GONUTS page
- ↑ Takata H et al. (2005) Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae. Mol Cell 17: 573-83 PubMed GONUTS page
- ↑ Bhaskara V et al. (2007) Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes. Mol Cell 25: 647-61 PubMed GONUTS page
