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YEAST:ATG18
Contents |
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | ATG18 (synonyms: AUT10, CVT18, NMR1, SVP1) | |
| Protein Name(s) | Autophagy-related protein 18
Cytoplasm to vacuole targeting protein 18 Needed for premeiotic replication protein 1 Swollen vacuole phenotype protein 1 | |
| External Links | ||
| UniProt | P43601 | |
| EMBL | D50617 BK006940 | |
| PIR | S56276 | |
| RefSeq | NP_444297.1 | |
| ProteinModelPortal | P43601 | |
| SMR | P43601 | |
| DIP | DIP-5185N | |
| IntAct | P43601 | |
| MINT | MINT-541235 | |
| STRING | P43601 | |
| EnsemblFungi | YFR021W | |
| GeneID | 850577 | |
| KEGG | sce:YFR021W | |
| NMPDR | fig|4932.3.peg.2310 | |
| CYGD | YFR021w | |
| SGD | S000001917 | |
| eggNOG | fuNOG05157 | |
| GeneTree | EFGT00050000004137 | |
| HOGENOM | HBG443829 | |
| OMA | RGGDCIL | |
| OrthoDB | EOG4M0J97 | |
| NextBio | 966400 | |
| ArrayExpress | P43601 | |
| Genevestigator | P43601 | |
| GermOnline | YFR021W | |
| GO | GO:0005829 GO:0005768 GO:0000329 GO:0070772 GO:0034045 GO:0080025 GO:0043130 GO:0032258 GO:0045324 GO:0016236 GO:0030242 GO:0034727 GO:0006624 | |
| InterPro | IPR015943 IPR001680 IPR011046 IPR017986 | |
| Gene3D | G3DSA:2.130.10.10 | |
| Pfam | PF00400 | |
| SMART | SM00320 | |
| SUPFAM | SSF50978 | |
| PROSITE | PS00678 PS50082 PS50294 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000329 |
fungal-type vacuole membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0000407 |
pre-autophagosomal structure |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005768 |
endosome |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005773 |
vacuole |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005774 |
vacuolar membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0271 |
C |
Seeded From UniProt |
|||
| GO:0005774 |
vacuolar membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006624 |
vacuolar protein processing |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006914 |
autophagy |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0015031 |
protein transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016236 |
macroautophagy |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0030242 |
peroxisome degradation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0032258 |
CVT pathway |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0032258 |
CVT pathway |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0034045 |
pre-autophagosomal structure membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0221 |
C |
Seeded From UniProt |
|||
| GO:0034727 |
piecemeal microautophagy of nucleus |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0035091 |
phosphatidylinositol binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0043130 |
ubiquitin binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0045324 |
late endosome to vacuole transport |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0070772 |
PAS complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0070772 |
PAS complex |
IPI: Inferred from Physical Interaction |
SGD:S000004378 |
C |
Seeded From UniProt |
|||
| GO:0080025 |
phosphatidylinositol-3,5-bisphosphate binding |
PANTHER:PTHR11227_AN1 |
F |
Seeded From UniProt |
| |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Dove SK et al. (2004) Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J 23: 1922-33 PubMed GONUTS page
- ↑ Ma J et al. (2008) Localization of autophagy-related proteins in yeast using a versatile plasmid-based resource of fluorescent protein fusions. Autophagy 4: 792-800 PubMed GONUTS page
- ↑ 3.0 3.1 Efe JA et al. (2007) Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate. Mol Biol Cell 18: 4232-44 PubMed GONUTS page
- ↑ Krick R et al. (2008) Dissecting the localization and function of Atg18, Atg21 and Ygr223c. Autophagy 4: 896-910 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Barth H et al. (2001) Autophagy and the cytoplasm to vacuole targeting pathway both require Aut10p. FEBS Lett 508: 23-8 PubMed GONUTS page
- ↑ Guan J et al. (2001) Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris. Mol Biol Cell 12: 3821-38 PubMed GONUTS page
- ↑ Krick R et al. (2006) The relevance of the phosphatidylinositolphosphat-binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy. FEBS Lett 580: 4632-8 PubMed GONUTS page
- ↑ Krick R et al. (2008) Piecemeal microautophagy of the nucleus requires the core macroautophagy genes. Mol Biol Cell 19: 4492-505 PubMed GONUTS page
- ↑ Pashkova N et al. (2010) WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Mol Cell 40: 433-43 PubMed GONUTS page
- ↑ 10.0 10.1 Jin N et al. (2008) VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J 27: 3221-34 PubMed GONUTS page
