XENLA:EXO1

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Species (Taxon ID)	Xenopus laevis (African clawed frog). (taxon:8355)
Gene Name(s)	exo1 ( synonyms: exoi )
Protein Name(s)	Exonuclease 1 Exonuclease I
External Links
UniProt Identifier	EXO1_XENLA
UniProt Accessions	Q9W6K2, Q5XHF5,
EMBL	AF134570, BC084102,
RefSeq	NP_001083827.1,
Pfam	PF00867, PF00752,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008918	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020045	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008918	F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020045	F
	GO:0004518	nuclease activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006084	F
	GO:0004518	nuclease activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006085	F
	GO:0004518	nuclease activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006086	F
	GO:0004518	nuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0267	F
	GO:0004518	nuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0540	F
	GO:0004519	endonuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0255	F
	GO:0004527	exonuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0269	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9UQ84	C
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006084	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006085	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006086	P
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0228	P
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P
	GO:0006298	mismatch repair	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9UQ84	P
	GO:0006310	DNA recombination	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9UQ84	P
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0016788	hydrolase activity, acting on ester bonds	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019974	F
	GO:0045145	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9UQ84	F
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048256	flap endonuclease activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9UQ84	F
	GO:0051908	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity	PMID:21490081^[1]	IMP: Inferred from Mutant Phenotype		F	Fig 2. Wild-type xEXO1, but not mutant xEXO1 displayed strong activity towards the 5′ dsDNA. After 1 h of incubation at room temperature, the substrate was almost completely degraded.	complete
	GO:0000729	DNA double-strand break processing	PMID:21490081^[1]	IMP: Inferred from Mutant Phenotype		P	Fig 3. In xEXO1-depleted cytosol, DNA degradation was inhibited significantly. This effect was reversed by the addition of the wild-type recombinant xEXO1 protein.	complete
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008918	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020045	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008918	F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020045	F
	GO:0004518	nuclease activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006084	F
	GO:0004518	nuclease activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006085	F
	GO:0004518	nuclease activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006086	F
	GO:0004518	nuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0267	F
	GO:0004518	nuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0540	F
	GO:0004519	endonuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0255	F
	GO:0004527	exonuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0269	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9UQ84	C
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006084	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006085	P
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006086	P
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0228	P
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P
	GO:0006298	mismatch repair	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9UQ84	P
	GO:0006310	DNA recombination	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9UQ84	P
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0016788	hydrolase activity, acting on ester bonds	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019974	F
	GO:0045145	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9UQ84	F
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048256	flap endonuclease activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9UQ84	F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Liao S et al. (2011) Mechanistic analysis of Xenopus EXO1's function in 5'-strand resection at DNA double-strand breaks. Nucleic Acids Res 39: 5967-77 PubMed GONUTS page

[PMID:21490081-0] 1.0 ^1.1 Liao S et al. (2011) Mechanistic analysis of Xenopus EXO1's function in 5'-strand resection at DNA double-strand breaks. Nucleic Acids Res 39: 5967-77 PubMed GONUTS page

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XENLA:EXO1

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