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WB:unc-5

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Contents

Species (Taxon ID) Caenorhabditis elegans (nematode) (taxon:6239)
Gene Name(s) unc-5 ( synonyms: B0273.4 )
Protein Name(s) No Information Provided.
External Links
WB WBGene00006745

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005887

integral to plasma membrane

WB_REF:WBPaper00001619
PMID:1384987[1]

RCA: Inferred from Reviewed Computational Analysis

C

From WB

GO:0007165

signal transduction

PMID:12520011[2]
PMID:12654719[3]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR000488

P

From WB

GO:0007411

axon guidance

WB_REF:WBPaper00027119
PMID:16495308[4]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00086084
WB:WBPhenotype:0000384

P

From WB

GO:0008045

motor axon guidance

WB_REF:WBPaper00003014
PMID:9473333[5]

IMP: Inferred from Mutant Phenotype

WB:WBVar00142936

P

From WB

GO:0008045

motor axon guidance

WB_REF:WBPaper00005582
PMID:12435363[6]

IMP: Inferred from Mutant Phenotype

WB:WBVar00142936
WB:WBVar00142997
WB:WBVar00145228
WB:WBVar00145234
WB:WBVar00145236
WB:WBVar00145258

P

From WB

GO:0008045

motor axon guidance

WB_REF:WBPaper00027119
PMID:16495308[4]

IMP: Inferred from Mutant Phenotype

WB:WBVar00142936

P

From WB

GO:0008046

axon guidance receptor activity

WB_REF:WBPaper00001619
PMID:1384987[1]

ISS: Inferred from Sequence or Structural Similarity

Pfam:PF00047
Pfam:PF00090

F

From WB

GO:0008078

mesodermal cell migration

WB_REF:WBPaper00005582
PMID:12435363[6]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088153
WB:WBVar00142936
WB:WBVar00142997
WB:WBVar00143294
WB:WBVar00143322
WB:WBVar00143487
WB:WBVar00145228
WB:WBVar00145234
WB:WBVar00145236
WB:WBVar00145258

P

From WB

GO:0016021

integral to membrane

PMID:12520011[2]
PMID:12654719[3]

IEA: Inferred from Electronic Annotation

CBS:TMHMM

C

From WB

GO:0016358

dendrite development

WB_REF:WBPaper00037977
PMID:21205795[7]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00084981
WB:WBPhenotype:0000882

P

From WB

GO:0033563

dorsal/ventral axon guidance

WB_REF:WBPaper00003014
PMID:9473333[5]

IMP: Inferred from Mutant Phenotype

WB:WBVar00142936

P

From WB

GO:0035262

gonad morphogenesis

WB_REF:WBPaper00001619
PMID:1384987[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00142936

P

From WB

GO:0035262

gonad morphogenesis

WB_REF:WBPaper00005582
PMID:12435363[6]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088153
WB:WBVar00142936
WB:WBVar00142997
WB:WBVar00143294
WB:WBVar00143322
WB:WBVar00143487
WB:WBVar00145228
WB:WBVar00145234
WB:WBVar00145236
WB:WBVar00145258

P

From WB

GO:0040017

positive regulation of locomotion

WB_REF:WBPaper00001619
PMID:1384987[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00142936

P

From WB

GO:0040017

positive regulation of locomotion

WB_REF:WBPaper00005582
PMID:12435363[6]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088153
WB:WBVar00142936
WB:WBVar00142997
WB:WBVar00143294
WB:WBVar00143322
WB:WBVar00143487
WB:WBVar00145228
WB:WBVar00145234
WB:WBVar00145236
WB:WBVar00145258

P

From WB

GO:0045773

positive regulation of axon extension

WB_REF:WBPaper00005582
PMID:12435363[6]

IMP: Inferred from Mutant Phenotype

WB:WBVar00142936
WB:WBVar00142997
WB:WBVar00145228
WB:WBVar00145234
WB:WBVar00145236
WB:WBVar00145258

P

From WB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 Leung-Hagesteijn C et al. (1992) UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell 71: 289-99 PubMed GONUTS page
  2. 2.0 2.1 Mulder NJ et al. (2003) The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res 31: 315-8 PubMed GONUTS page
  3. 3.0 3.1 Camon E et al. (2003) The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro. Genome Res 13: 662-72 PubMed GONUTS page
  4. 4.0 4.1 Dixon SJ et al. (2006) FGF negatively regulates muscle membrane extension in Caenorhabditis elegans. Development 133: 1263-75 PubMed GONUTS page
  5. 5.0 5.1 Colavita A & Culotti JG (1998) Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans. Dev Biol 194: 72-85 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Killeen M et al. (2002) UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains. Dev Biol 251: 348-66 PubMed GONUTS page
  7. Aguirre-Chen C et al. (2011) C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites. Development 138: 507-18 PubMed GONUTS page
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