WB:eps-8

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Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000003	reproduction	WB_REF:WBPaper00027756 PMID:16845399^[1]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00064553 WB:WBPhenotype:0000688	P	From WB
	GO:0002119	nematode larval development	WB_REF:WBPaper00004651 PMID:11231151^[2]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00002358 WB:WBPhenotype:0000059	P	From WB
	GO:0002119	nematode larval development	WB_REF:WBPaper00006395 PMID:14551910^[3]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00026878 WB:WBPhenotype:0000054	P	From WB
	GO:0002119	nematode larval development	WB_REF:WBPaper00024497 PMID:15489339^[4]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00037604 WB:WBPhenotype:0000059	P	From WB
	GO:0002119	nematode larval development	WB_REF:WBPaper00024614 PMID:15558032^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00061103 WB:WBPhenotype:0000054	P	From WB
	GO:0002119	nematode larval development	WB_REF:WBPaper00024614 PMID:15558032^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00061104 WB:WBPhenotype:0000054	P	From WB
	GO:0002119	nematode larval development	WB_REF:WBPaper00032244 PMID:18833327^[6]	IMP: Inferred from Mutant Phenotype	WB:WBVar00000643	P	From WB
	GO:0005903	brush border	WB_REF:WBPaper00024614 PMID:15558032^[5]	IDA: Inferred from Direct Assay		C	From WB
	GO:0005903	brush border	WB_REF:WBPaper00036447 PMID:20532239^[7]	IDA: Inferred from Direct Assay		C	From WB
	GO:0006898	receptor-mediated endocytosis	WB_REF:WBPaper00030951 PMID:17704769^[8]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00071496 WB:WBPhenotype:0001425	P	From WB
	GO:0008092	cytoskeletal protein binding	WB_REF:WBPaper00032244 PMID:18833327^[6]	IPI: Inferred from Physical Interaction	WB:WBGene00006882	F	From WB
	GO:0009790	embryo development	WB_REF:WBPaper00032244 PMID:18833327^[6]	IMP: Inferred from Mutant Phenotype	WB:WBVar00088058	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00005194 PMID:11922622^[9]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00024294 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00006395 PMID:14551910^[3]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00026878 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00024497 PMID:15489339^[4]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00037604 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00024614 PMID:15558032^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00061103 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00024614 PMID:15558032^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00061104 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00027756 PMID:16845399^[1]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00064527 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00027756 PMID:16845399^[1]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00064770 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00032244 PMID:18833327^[6]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00078003 WB:WBPhenotype:0000050	P	From WB
	GO:0030421	defecation	WB_REF:WBPaper00024614 PMID:15558032^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00061103 WB:WBPhenotype:0000651	P	From WB
	GO:0030421	defecation	WB_REF:WBPaper00024614 PMID:15558032^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00061104 WB:WBPhenotype:0000651	P	From WB
	GO:0030421	defecation	WB_REF:WBPaper00024614 PMID:15558032^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00061105 WB:WBPhenotype:0000651	P	From WB
	GO:0031012	extracellular matrix	WB_REF:WBPaper00032244 PMID:18833327^[6]	IDA: Inferred from Direct Assay		C	From WB
	GO:0040007	growth	WB_REF:WBPaper00004651 PMID:11231151^[2]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00002358 WB:WBPhenotype:0000059	P	From WB
	GO:0040007	growth	WB_REF:WBPaper00024497 PMID:15489339^[4]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00037604 WB:WBPhenotype:0000059	P	From WB
	GO:0040010	positive regulation of growth rate	WB_REF:WBPaper00005654 PMID:12529635^[10]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00009401 WB:WBPhenotype:0000031	P	From WB
	GO:0040010	positive regulation of growth rate	WB_REF:WBPaper00006395 PMID:14551910^[3]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00026878 WB:WBPhenotype:0000031	P	From WB
	GO:0040011	locomotion	WB_REF:WBPaper00005654 PMID:12529635^[10]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00009401 WB:WBPhenotype:0000643	P	From WB
	GO:0040011	locomotion	WB_REF:WBPaper00006395 PMID:14551910^[3]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00026878 WB:WBPhenotype:0000643	P	From WB
	GO:0045109	intermediate filament organization	WB_REF:WBPaper00032244 PMID:18833327^[6]	IMP: Inferred from Mutant Phenotype	WB:WBVar00088058	P	From WB
	GO:0045177	apical part of cell	WB_REF:WBPaper00036447 PMID:20532239^[7]	IDA: Inferred from Direct Assay		C	From WB
	GO:0045185	maintenance of protein location	WB_REF:WBPaper00032244 PMID:18833327^[6]	IMP: Inferred from Mutant Phenotype	WB:WBVar00088058	P	From WB
	GO:0048546	digestive tract morphogenesis	WB_REF:WBPaper00024614 PMID:15558032^[5]	IMP: Inferred from Mutant Phenotype	WB:WBVar00091826	P	From WB
	GO:0048546	digestive tract morphogenesis	WB_REF:WBPaper00036447 PMID:20532239^[7]	IMP: Inferred from Mutant Phenotype	WB:WBVar00000643	P	From WB
	GO:0048598	embryonic morphogenesis	WB_REF:WBPaper00032244 PMID:18833327^[6]	IGI: Inferred from Genetic Interaction	WB:WBGene00006882	P	From WB
	GO:0048598	embryonic morphogenesis	WB_REF:WBPaper00032244 PMID:18833327^[6]	IMP: Inferred from Mutant Phenotype	WB:WBVar00000643	P	From WB
	GO:0048730	epidermis morphogenesis	WB_REF:WBPaper00032244 PMID:18833327^[6]	IMP: Inferred from Mutant Phenotype	WB:WBVar00000643	P	From WB
	GO:0051015	actin filament binding	WB_REF:WBPaper00036447 PMID:20532239^[7]	IDA: Inferred from Direct Assay		F	From WB
	GO:0051016	barbed-end actin filament capping	WB_REF:WBPaper00024614 PMID:15558032^[5]	IDA: Inferred from Direct Assay		P	From WB
	GO:0051016	barbed-end actin filament capping	WB_REF:WBPaper00036447 PMID:20532239^[7]	IDA: Inferred from Direct Assay		P	From WB
	GO:0051017	actin filament bundle assembly	WB_REF:WBPaper00036447 PMID:20532239^[7]	IDA: Inferred from Direct Assay		P	From WB
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Lehner B et al. (2006) Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Nat Genet 38: 896-903 PubMed GONUTS page
↑ ^2.0 ^2.1 Maeda I et al. (2001) Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Curr Biol 11: 171-6 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Simmer F et al. (2003) Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol 1: E12 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Rual JF et al. (2004) Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res 14: 2162-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Croce A et al. (2004) A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans. Nat Cell Biol 6: 1173-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Ding M et al. (2008) The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19. PLoS One 3: e3346 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Hertzog M et al. (2010) Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping. PLoS Biol 8: e1000387 PubMed GONUTS page
↑ Balklava Z et al. (2007) Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic. Nat Cell Biol 9: 1066-73 PubMed GONUTS page
↑ Tsuboi D et al. (2002) Isolation of the interacting molecules with GEX-3 by a novel functional screening. Biochem Biophys Res Commun 292: 697-701 PubMed GONUTS page
↑ ^10.0 ^10.1 Kamath RS et al. (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421: 231-7 PubMed GONUTS page

[PMID:16845399-0] 1.0 ^1.1 ^1.2 Lehner B et al. (2006) Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Nat Genet 38: 896-903 PubMed GONUTS page

[PMID:11231151-1] 2.0 ^2.1 Maeda I et al. (2001) Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Curr Biol 11: 171-6 PubMed GONUTS page

[PMID:14551910-2] 3.0 ^3.1 ^3.2 ^3.3 Simmer F et al. (2003) Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol 1: E12 PubMed GONUTS page

[PMID:15489339-3] 4.0 ^4.1 ^4.2 Rual JF et al. (2004) Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res 14: 2162-8 PubMed GONUTS page

[PMID:15558032-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Croce A et al. (2004) A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans. Nat Cell Biol 6: 1173-9 PubMed GONUTS page

[PMID:18833327-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Ding M et al. (2008) The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19. PLoS One 3: e3346 PubMed GONUTS page

[PMID:20532239-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Hertzog M et al. (2010) Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping. PLoS Biol 8: e1000387 PubMed GONUTS page

[PMID:17704769-7] Balklava Z et al. (2007) Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic. Nat Cell Biol 9: 1066-73 PubMed GONUTS page

[PMID:11922622-8] Tsuboi D et al. (2002) Isolation of the interacting molecules with GEX-3 by a novel functional screening. Biochem Biophys Res Commun 292: 697-701 PubMed GONUTS page

[PMID:12529635-9] 10.0 ^10.1 Kamath RS et al. (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421: 231-7 PubMed GONUTS page

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Species (Taxon ID)	Caenorhabditis elegans (nematode) (taxon:6239)
Gene Name(s)	eps-8 ( synonyms: Y57G11C.24, gei-19 )
Protein Name(s)	No Information Provided.
External Links
WB	WBGene00001330

WB:eps-8

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