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WB:egl-1
Contents |
| Species (Taxon ID) | Caenorhabditis elegans (nematode) (taxon:6239) | |
| Gene Name(s) | egl-1 ( synonyms: F23B12.9 ) | |
| Protein Name(s) | No Information Provided. | |
| External Links | ||
| WB | WBGene00001170 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
WB_REF:WBPaper00003077 |
IPI: Inferred from Physical Interaction |
WB:WBGene00000423 |
F |
From WB |
||
| GO:0005515 |
protein binding |
WB_REF:WBPaper00004397 |
IPI: Inferred from Physical Interaction |
WB:WBGene00000423 |
F |
From WB |
||
| GO:0005739 |
mitochondrion |
WB_REF:WBPaper00004308 |
IDA: Inferred from Direct Assay |
C |
From WB |
|||
| GO:0005829 |
cytosol |
WB_REF:WBPaper00003307 |
IDA: Inferred from Direct Assay |
C |
From WB |
|||
| GO:0006915 |
apoptotic process |
WB_REF:WBPaper00028561 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00077438 |
P |
From WB |
||
| GO:0006915 |
apoptotic process |
WB_REF:WBPaper00028561 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00077439 |
P |
From WB |
||
| GO:0006915 |
apoptotic process |
WB_REF:WBPaper00028561 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00077440 |
P |
From WB |
||
| GO:0008634 |
negative regulation of survival gene product expression |
WB_REF:WBPaper00004397 |
IDA: Inferred from Direct Assay |
P |
From WB |
|||
| GO:0008637 |
apoptotic mitochondrial changes |
WB_REF:WBPaper00024967 |
IDA: Inferred from Direct Assay |
P |
From WB |
|||
| GO:0008637 |
apoptotic mitochondrial changes |
WB_REF:WBPaper00024967 |
IMP: Inferred from Mutant Phenotype |
P |
From WB |
|||
| GO:0018991 |
oviposition |
WB_REF:WBPaper00003077 |
IMP: Inferred from Mutant Phenotype |
WB:WBVar00089949 |
P |
From WB |
||
| GO:0019987 |
negative regulation of anti-apoptosis |
WB_REF:WBPaper00004397 |
IGI: Inferred from Genetic Interaction |
WB:WBGene00000423 |
P |
From WB |
||
| GO:0019987 |
negative regulation of anti-apoptosis |
WB_REF:WBPaper00004397 |
IMP: Inferred from Mutant Phenotype |
WB:WBVar00090654 |
P |
From WB |
||
| GO:0032091 |
negative regulation of protein binding |
WB_REF:WBPaper00004397 |
IDA: Inferred from Direct Assay |
P |
From WB |
|||
| GO:0043068 |
positive regulation of programmed cell death |
WB_REF:WBPaper00003077 |
IMP: Inferred from Mutant Phenotype |
WB:WBVar00089949 |
P |
From WB |
||
| GO:0043068 |
positive regulation of programmed cell death |
WB_REF:WBPaper00003077 |
ISS: Inferred from Sequence or Structural Similarity |
NCBI_NM:U34584 |
P |
From WB |
||
| GO:0043068 |
positive regulation of programmed cell death |
WB_REF:WBPaper00006120 |
IEP: Inferred from Expression Pattern |
P |
From WB |
|||
| GO:0043068 |
positive regulation of programmed cell death |
WB_REF:WBPaper00006120 |
IMP: Inferred from Mutant Phenotype |
WB:WBVar00089950 |
P |
From WB |
||
| GO:0043231 |
intracellular membrane-bounded organelle |
WB_REF:WBPaper00003307 |
IDA: Inferred from Direct Assay |
C |
From WB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Conradt B & Horvitz HR (1998) The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93: 519-29 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Parrish J et al. (2000) Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors. Proc Natl Acad Sci U S A 97: 11916-21 PubMed GONUTS page
- ↑ del Peso L et al. (2000) Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans. J Biol Chem 275: 27205-11 PubMed GONUTS page
- ↑ 4.0 4.1 del Peso L et al. (1998) Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation. J Biol Chem 273: 33495-500 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Park D et al. (2006) Pax2/5/8 proteins promote cell survival in C. elegans. Development 133: 4193-202 PubMed GONUTS page
- ↑ 6.0 6.1 Jagasia R et al. (2005) DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans. Nature 433: 754-60 PubMed GONUTS page
- ↑ 7.0 7.1 Thellmann M et al. (2003) The Snail-like CES-1 protein of C. elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins. Development 130: 4057-71 PubMed GONUTS page
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