WB:dyn-1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000003	reproduction	WB_REF:WBPaper00025054 PMID:15791247^[1]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00039407 WB:WBPhenotype:0000689	P	From WB
	GO:0000003	reproduction	WB_REF:WBPaper00038381 PMID:21529718^[2]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00085562 WB:WBPhenotype:0000688	P	From WB
	GO:0001891	phagocytic cup	WB_REF:WBPaper00031805 PMID:18425118^[3]	IDA: Inferred from Direct Assay		C	From WB
	GO:0002119	nematode larval development	WB_REF:WBPaper00006395 PMID:14551910^[4]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00024449 WB:WBPhenotype:0000059	P	From WB
	GO:0002119	nematode larval development	WB_REF:WBPaper00024497 PMID:15489339^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00028338 WB:WBPhenotype:0000054	P	From WB
	GO:0002119	nematode larval development	WB_REF:WBPaper00024497 PMID:15489339^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00028338 WB:WBPhenotype:0000059	P	From WB
	GO:0003924	GTPase activity	PMID:12520011^[6] PMID:12654719^[7]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR001401	F	From WB
	GO:0003924	GTPase activity	PMID:12520011^[6] PMID:12654719^[7]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR003130	F	From WB
	GO:0003924	GTPase activity	WB_REF:WBPaper00002892 PMID:9294229^[8]	ISS: Inferred from Sequence or Structural Similarity		F	From WB
	GO:0003924	GTPase activity	WB_REF:WBPaper00035546 PMID:20016007^[9]	IDA: Inferred from Direct Assay		F	From WB
	GO:0005525	GTP binding	PMID:12520011^[6] PMID:12654719^[7]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR000375	F	From WB
	GO:0005525	GTP binding	PMID:12520011^[6] PMID:12654719^[7]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR001401	F	From WB
	GO:0005525	GTP binding	PMID:12520011^[6] PMID:12654719^[7]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR003130	F	From WB
	GO:0005543	phospholipid binding	PMID:12520011^[6] PMID:12654719^[7]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR001849	F	From WB
	GO:0005876	spindle microtubule	WB_REF:WBPaper00005664 PMID:12498685^[10]	IDA: Inferred from Direct Assay		C	From WB
	GO:0006897	endocytosis	WB_REF:WBPaper00002892 PMID:9294229^[8]	IMP: Inferred from Mutant Phenotype		P	From WB
	GO:0006897	endocytosis	WB_REF:WBPaper00004883 PMID:11560892^[11]	IMP: Inferred from Mutant Phenotype	WB:WBVar00088400	P	From WB
	GO:0006898	receptor-mediated endocytosis	WB_REF:WBPaper00003831 PMID:10588660^[12]	IMP: Inferred from Mutant Phenotype		P	From WB
	GO:0006898	receptor-mediated endocytosis	WB_REF:WBPaper00027659 PMID:16740477^[13]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00065880 WB:WBPhenotype:0001425	P	From WB
	GO:0006898	receptor-mediated endocytosis	WB_REF:WBPaper00030951 PMID:17704769^[14]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00071641 WB:WBPhenotype:0001425	P	From WB
	GO:0006915	apoptotic process	WB_REF:WBPaper00038381 PMID:21529718^[2]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00085562 WB:WBPhenotype:0000183	P	From WB
	GO:0006915	apoptotic process	WB_REF:WBPaper00038381 PMID:21529718^[2]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00085562 WB:WBPhenotype:0000730	P	From WB
	GO:0007281	germ cell development	WB_REF:WBPaper00005664 PMID:12498685^[10]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00064262 WB:WBPhenotype:0000812	P	From WB
	GO:0008219	cell death	WB_REF:WBPaper00027659 PMID:16740477^[13]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00065879 WB:WBPhenotype:0000729	P	From WB
	GO:0009790	embryo development	WB_REF:WBPaper00004812 PMID:11483962^[15]	IMP: Inferred from Mutant Phenotype		P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00003831 PMID:10588660^[12]	IMP: Inferred from Mutant Phenotype		P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00005194 PMID:11922622^[16]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00024283 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00005654 PMID:12529635^[17]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00008324 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00006395 PMID:14551910^[4]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00024449 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00024200 PMID:15166316^[18]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00080545 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00034638 PMID:19531359^[19]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00080726 WB:WBPhenotype:0000050	P	From WB
	GO:0010940	positive regulation of necrotic cell death	WB_REF:WBPaper00040525 PMID:22157748^[20]	IGI: Inferred from Genetic Interaction	WB:WBGene00003168	P	From WB
	GO:0018996	molting cycle, collagen and cuticulin-based cuticle	WB_REF:WBPaper00005654 PMID:12529635^[17]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00008324 WB:WBPhenotype:0000638	P	From WB
	GO:0018996	molting cycle, collagen and cuticulin-based cuticle	WB_REF:WBPaper00026763 PMID:16122351^[21]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00066834 WB:WBPhenotype:0000638	P	From WB
	GO:0030163	protein catabolic process	WB_REF:WBPaper00027612 PMID:16672374^[22]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00083352 WB:WBPhenotype:0001645	P	From WB
	GO:0030496	midbody	WB_REF:WBPaper00005664 PMID:12498685^[10]	IDA: Inferred from Direct Assay		C	From WB
	GO:0031143	pseudopodium	WB_REF:WBPaper00027659 PMID:16740477^[13]	IDA: Inferred from Direct Assay		C	From WB
	GO:0031410	cytoplasmic vesicle	WB_REF:WBPaper00005664 PMID:12498685^[10]	IDA: Inferred from Direct Assay		C	From WB
	GO:0032154	cleavage furrow	WB_REF:WBPaper00005664 PMID:12498685^[10]	IDA: Inferred from Direct Assay		C	From WB
	GO:0040007	growth	WB_REF:WBPaper00006395 PMID:14551910^[4]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00024449 WB:WBPhenotype:0000059	P	From WB
	GO:0040007	growth	WB_REF:WBPaper00024497 PMID:15489339^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00028338 WB:WBPhenotype:0000059	P	From WB
	GO:0040011	locomotion	WB_REF:WBPaper00002892 PMID:9294229^[8]	IMP: Inferred from Mutant Phenotype		P	From WB
	GO:0040011	locomotion	WB_REF:WBPaper00005654 PMID:12529635^[17]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00008324 WB:WBPhenotype:0000643	P	From WB
	GO:0040011	locomotion	WB_REF:WBPaper00006395 PMID:14551910^[4]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00024449 WB:WBPhenotype:0000643	P	From WB
	GO:0040011	locomotion	WB_REF:WBPaper00024200 PMID:15166316^[18]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00080545 WB:WBPhenotype:0000643	P	From WB
	GO:0040039	inductive cell migration	WB_REF:WBPaper00028783 PMID:17090602^[23]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00065691 WB:WBPhenotype:0000195	P	From WB
	GO:0043652	engulfment of apoptotic cell	WB_REF:WBPaper00027659 PMID:16740477^[13]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00065881 WB:WBPhenotype:0000885	P	From WB
	GO:0045177	apical part of cell	WB_REF:WBPaper00035546 PMID:20016007^[9]	IDA: Inferred from Direct Assay		C	From WB
	GO:0045202	synapse	WB_REF:WBPaper00004812 PMID:11483962^[15]	IDA: Inferred from Direct Assay		C	From WB
	GO:0045335	phagocytic vesicle	WB_REF:WBPaper00027659 PMID:16740477^[13]	IDA: Inferred from Direct Assay		C	From WB
	GO:0045335	phagocytic vesicle	WB_REF:WBPaper00031805 PMID:18425118^[3]	IDA: Inferred from Direct Assay		C	From WB
	GO:0090386	phagosome maturation involved in apoptotic cell clearance	WB_REF:WBPaper00038320 PMID:21494661^[24]	IMP: Inferred from Mutant Phenotype	WB:WBVar00088400	P	From WB
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sönnichsen B et al. (2005) Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature 434: 462-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Green RA et al. (2011) A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell 145: 470-82 PubMed GONUTS page
↑ ^3.0 ^3.1 Kinchen JM et al. (2008) A pathway for phagosome maturation during engulfment of apoptotic cells. Nat Cell Biol 10: 556-66 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Simmer F et al. (2003) Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol 1: E12 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Rual JF et al. (2004) Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res 14: 2162-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Mulder NJ et al. (2003) The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res 31: 315-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Camon E et al. (2003) The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro. Genome Res 13: 662-72 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Clark SG et al. (1997) A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C. elegans. Proc Natl Acad Sci U S A 94: 10438-43 PubMed GONUTS page
↑ ^9.0 ^9.1 He B et al. (2010) Live-cell imaging in Caenorhabditis elegans reveals the distinct roles of dynamin self-assembly and guanosine triphosphate hydrolysis in the removal of apoptotic cells. Mol Biol Cell 21: 610-29 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Thompson HM et al. (2002) The large GTPase dynamin associates with the spindle midzone and is required for cytokinesis. Curr Biol 12: 2111-7 PubMed GONUTS page
↑ Fares H & Greenwald I (2001) Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte uptake defective mutants. Genetics 159: 133-45 PubMed GONUTS page
↑ ^12.0 ^12.1 Grant B & Hirsh D (1999) Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte. Mol Biol Cell 10: 4311-26 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Yu X et al. (2006) C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells. Dev Cell 10: 743-57 PubMed GONUTS page
↑ Balklava Z et al. (2007) Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic. Nat Cell Biol 9: 1066-73 PubMed GONUTS page
↑ ^15.0 ^15.1 Salcini AE et al. (2001) The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling. Nat Cell Biol 3: 755-60 PubMed GONUTS page
↑ Tsuboi D et al. (2002) Isolation of the interacting molecules with GEX-3 by a novel functional screening. Biochem Biophys Res Commun 292: 697-701 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Kamath RS et al. (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421: 231-7 PubMed GONUTS page
↑ ^18.0 ^18.1 Skop AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305: 61-6 PubMed GONUTS page
↑ Nakayama Y et al. (2009) Dynamin participates in the maintenance of anterior polarity in the Caenorhabditis elegans embryo. Dev Cell 16: 889-900 PubMed GONUTS page
↑ Troulinaki K & Tavernarakis N (2011) Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans. EMBO J 31: 654-66 PubMed GONUTS page
↑ Frand AR et al. (2005) Functional genomic analysis of C. elegans molting. PLoS Biol 3: e312 PubMed GONUTS page
↑ Sato K et al. (2006) Dynamic regulation of caveolin-1 trafficking in the germ line and embryo of Caenorhabditis elegans. Mol Biol Cell 17: 3085-94 PubMed GONUTS page
↑ Cram EJ et al. (2006) A systematic RNA interference screen reveals a cell migration gene network in C. elegans. J Cell Sci 119: 4811-8 PubMed GONUTS page
↑ Almendinger J et al. (2011) A conserved role for SNX9-family members in the regulation of phagosome maturation during engulfment of apoptotic cells. PLoS One 6: e18325 PubMed GONUTS page

[PMID:15791247-0] Sönnichsen B et al. (2005) Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature 434: 462-9 PubMed GONUTS page

[PMID:21529718-1] 2.0 ^2.1 ^2.2 Green RA et al. (2011) A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell 145: 470-82 PubMed GONUTS page

[PMID:18425118-2] 3.0 ^3.1 Kinchen JM et al. (2008) A pathway for phagosome maturation during engulfment of apoptotic cells. Nat Cell Biol 10: 556-66 PubMed GONUTS page

[PMID:14551910-3] 4.0 ^4.1 ^4.2 ^4.3 Simmer F et al. (2003) Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol 1: E12 PubMed GONUTS page

[PMID:15489339-4] 5.0 ^5.1 ^5.2 Rual JF et al. (2004) Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res 14: 2162-8 PubMed GONUTS page

[PMID:12520011-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Mulder NJ et al. (2003) The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res 31: 315-8 PubMed GONUTS page

[PMID:12654719-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Camon E et al. (2003) The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro. Genome Res 13: 662-72 PubMed GONUTS page

[PMID:9294229-7] 8.0 ^8.1 ^8.2 Clark SG et al. (1997) A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C. elegans. Proc Natl Acad Sci U S A 94: 10438-43 PubMed GONUTS page

[PMID:20016007-8] 9.0 ^9.1 He B et al. (2010) Live-cell imaging in Caenorhabditis elegans reveals the distinct roles of dynamin self-assembly and guanosine triphosphate hydrolysis in the removal of apoptotic cells. Mol Biol Cell 21: 610-29 PubMed GONUTS page

[PMID:12498685-9] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Thompson HM et al. (2002) The large GTPase dynamin associates with the spindle midzone and is required for cytokinesis. Curr Biol 12: 2111-7 PubMed GONUTS page

[PMID:11560892-10] Fares H & Greenwald I (2001) Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte uptake defective mutants. Genetics 159: 133-45 PubMed GONUTS page

[PMID:10588660-11] 12.0 ^12.1 Grant B & Hirsh D (1999) Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte. Mol Biol Cell 10: 4311-26 PubMed GONUTS page

[PMID:16740477-12] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Yu X et al. (2006) C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells. Dev Cell 10: 743-57 PubMed GONUTS page

[PMID:17704769-13] Balklava Z et al. (2007) Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic. Nat Cell Biol 9: 1066-73 PubMed GONUTS page

[PMID:11483962-14] 15.0 ^15.1 Salcini AE et al. (2001) The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling. Nat Cell Biol 3: 755-60 PubMed GONUTS page

[PMID:11922622-15] Tsuboi D et al. (2002) Isolation of the interacting molecules with GEX-3 by a novel functional screening. Biochem Biophys Res Commun 292: 697-701 PubMed GONUTS page

[PMID:12529635-16] 17.0 ^17.1 ^17.2 Kamath RS et al. (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421: 231-7 PubMed GONUTS page

[PMID:15166316-17] 18.0 ^18.1 Skop AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305: 61-6 PubMed GONUTS page

[PMID:19531359-18] Nakayama Y et al. (2009) Dynamin participates in the maintenance of anterior polarity in the Caenorhabditis elegans embryo. Dev Cell 16: 889-900 PubMed GONUTS page

[PMID:22157748-19] Troulinaki K & Tavernarakis N (2011) Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans. EMBO J 31: 654-66 PubMed GONUTS page

[PMID:16122351-20] Frand AR et al. (2005) Functional genomic analysis of C. elegans molting. PLoS Biol 3: e312 PubMed GONUTS page

[PMID:16672374-21] Sato K et al. (2006) Dynamic regulation of caveolin-1 trafficking in the germ line and embryo of Caenorhabditis elegans. Mol Biol Cell 17: 3085-94 PubMed GONUTS page

[PMID:17090602-22] Cram EJ et al. (2006) A systematic RNA interference screen reveals a cell migration gene network in C. elegans. J Cell Sci 119: 4811-8 PubMed GONUTS page

[PMID:21494661-23] Almendinger J et al. (2011) A conserved role for SNX9-family members in the regulation of phagosome maturation during engulfment of apoptotic cells. PLoS One 6: e18325 PubMed GONUTS page

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Species (Taxon ID)	Caenorhabditis elegans (nematode) (taxon:6239)
Gene Name(s)	dyn-1 ( synonyms: C02C6.1 )
Protein Name(s)	No Information Provided.
External Links
WB	WBGene00001130

WB:dyn-1

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References

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