WB:dhc-1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000003	reproduction	WB_REF:WBPaper00038381 PMID:21529718^[1]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00085605 WB:WBPhenotype:0000688	P	From WB
	GO:0000166	nucleotide binding	PMID:12520011^[2] PMID:12654719^[3]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR003593	F	From WB
	GO:0000910	cytokinesis	WB_REF:WBPaper00004901 PMID:11598181^[4]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00077542 WB:WBPhenotype:0001143	P	From WB
	GO:0000910	cytokinesis	WB_REF:WBPaper00025116 PMID:15616192^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00060973 WB:WBPhenotype:0001018	P	From WB
	GO:0000910	cytokinesis	WB_REF:WBPaper00025116 PMID:15616192^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00060973 WB:WBPhenotype:0001143	P	From WB
	GO:0000922	spindle pole	WB_REF:WBPaper00032910 PMID:19219036^[6]	IDA: Inferred from Direct Assay		C	From WB
	GO:0002119	nematode larval development	WB_REF:WBPaper00034764 PMID:19635841^[7]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00085215 WB:WBPhenotype:0000059	P	From WB
	GO:0003777	microtubule motor activity	PMID:12520011^[2] PMID:12654719^[3]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR004273	F	From WB
	GO:0005524	ATP binding	PMID:12520011^[2] PMID:12654719^[3]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR011704	F	From WB
	GO:0005635	nuclear envelope	WB_REF:WBPaper00025116 PMID:15616192^[5]	IDA: Inferred from Direct Assay		C	From WB
	GO:0005737	cytoplasm	WB_REF:WBPaper00025116 PMID:15616192^[5]	IDA: Inferred from Direct Assay		C	From WB
	GO:0005819	spindle	WB_REF:WBPaper00025116 PMID:15616192^[5]	IDA: Inferred from Direct Assay		C	From WB
	GO:0005819	spindle	WB_REF:WBPaper00032910 PMID:19219036^[6]	IDA: Inferred from Direct Assay		C	From WB
	GO:0005938	cell cortex	WB_REF:WBPaper00025116 PMID:15616192^[5]	IDA: Inferred from Direct Assay		C	From WB
	GO:0007018	microtubule-based movement	PMID:12520011^[2] PMID:12654719^[3]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR004273	P	From WB
	GO:0007052	mitotic spindle organization	WB_REF:WBPaper00025116 PMID:15616192^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00060973 WB:WBPhenotype:0001102	P	From WB
	GO:0007126	meiosis	WB_REF:WBPaper00024200 PMID:15166316^[8]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00080549 WB:WBPhenotype:0000775	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00004402 PMID:11099033^[9]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00000102 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00004509 PMID:11178279^[10]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00077276 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00004509 PMID:11178279^[10]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00077290 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00004540 PMID:11137018^[11]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00000209 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00005320 PMID:12011109^[12]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00022770 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00005515 PMID:12223405^[13]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00022752 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00006395 PMID:14551910^[14]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00026345 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00024200 PMID:15166316^[8]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00080549 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00025054 PMID:15791247^[15]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00053742 WB:WBPhenotype:0000050	P	From WB
	GO:0009792	embryo development ending in birth or egg hatching	WB_REF:WBPaper00033063 PMID:19357192^[16]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00078498 WB:WBPhenotype:0000050	P	From WB
	GO:0016887	ATPase activity	PMID:12520011^[2] PMID:12654719^[3]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR011704	F	From WB
	GO:0017111	nucleoside-triphosphatase activity	PMID:12520011^[2] PMID:12654719^[3]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR003593	F	From WB
	GO:0030286	dynein complex	PMID:12520011^[2] PMID:12654719^[3]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR004273	C	From WB
	GO:0035046	pronuclear migration	WB_REF:WBPaper00004402 PMID:11099033^[9]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00000102 WB:WBPhenotype:0001152	P	From WB
	GO:0035046	pronuclear migration	WB_REF:WBPaper00025054 PMID:15791247^[15]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00053742 WB:WBPhenotype:0001152	P	From WB
	GO:0035046	pronuclear migration	WB_REF:WBPaper00025116 PMID:15616192^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00060973 WB:WBPhenotype:0001152	P	From WB
	GO:0035046	pronuclear migration	WB_REF:WBPaper00026590 PMID:15866166^[17]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00063848 WB:WBPhenotype:0001152	P	From WB
	GO:0035047	centrosomal and pronuclear rotation	WB_REF:WBPaper00025116 PMID:15616192^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00060973 WB:WBPhenotype:0000766	P	From WB
	GO:0040007	growth	WB_REF:WBPaper00034764 PMID:19635841^[7]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00085215 WB:WBPhenotype:0000059	P	From WB
	GO:0040020	regulation of meiosis	WB_REF:WBPaper00035192 PMID:19752194^[18]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00082361 WB:WBPhenotype:0001038	P	From WB
	GO:0042127	regulation of cell proliferation	WB_REF:WBPaper00035192 PMID:19752194^[18]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00082361 WB:WBPhenotype:0001038	P	From WB
	GO:0048489	synaptic vesicle transport	WB_REF:WBPaper00028525 PMID:16996038^[19]	IMP: Inferred from Mutant Phenotype		P	From WB
	GO:0048599	oocyte development	WB_REF:WBPaper00025176 PMID:15883196^[20]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00079271 WB:WBPhenotype:0000105	P	From WB
	GO:0051296	establishment of meiotic spindle orientation	WB_REF:WBPaper00032910 PMID:19219036^[6]	IGI: Inferred from Genetic Interaction	WB:WBGene00006840	P	From WB
	GO:0051296	establishment of meiotic spindle orientation	WB_REF:WBPaper00032910 PMID:19219036^[6]	IMP: Inferred from Mutant Phenotype	WB:WBVar00094697	P	From WB
	GO:0051301	cell division	WB_REF:WBPaper00004901 PMID:11598181^[4]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00077542 WB:WBPhenotype:0001143	P	From WB
	GO:0051301	cell division	WB_REF:WBPaper00025116 PMID:15616192^[5]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00060973 WB:WBPhenotype:0001143	P	From WB
	GO:0051932	synaptic transmission, GABAergic	WB_REF:WBPaper00028525 PMID:16996038^[19]	IGI: Inferred from Genetic Interaction	WB:WBGene00003047	P	From WB
	GO:0051932	synaptic transmission, GABAergic	WB_REF:WBPaper00028525 PMID:16996038^[19]	IGI: Inferred from Genetic Interaction	WB:WBGene00006762	P	From WB
	GO:0051932	synaptic transmission, GABAergic	WB_REF:WBPaper00028525 PMID:16996038^[19]	IMP: Inferred from Mutant Phenotype		P	From WB
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Green RA et al. (2011) A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell 145: 470-82 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Mulder NJ et al. (2003) The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res 31: 315-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Camon E et al. (2003) The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro. Genome Res 13: 662-72 PubMed GONUTS page
↑ ^4.0 ^4.1 Yoder JH & Han M (2001) Cytoplasmic dynein light intermediate chain is required for discrete aspects of mitosis in Caenorhabditis elegans. Mol Biol Cell 12: 2921-33 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Schmidt DJ et al. (2005) Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations. Mol Biol Cell 16: 1200-12 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 van der Voet M et al. (2009) NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Nat Cell Biol 11: 269-77 PubMed GONUTS page
↑ ^7.0 ^7.1 Zhou K et al. (2009) A ZYG-12-dynein interaction at the nuclear envelope defines cytoskeletal architecture in the C. elegans gonad. J Cell Biol 186: 229-41 PubMed GONUTS page
↑ ^8.0 ^8.1 Skop AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305: 61-6 PubMed GONUTS page
↑ ^9.0 ^9.1 Fraser AG et al. (2000) Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408: 325-30 PubMed GONUTS page
↑ ^10.0 ^10.1 Kamath RS et al. (2001) Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol 2: RESEARCH0002 PubMed GONUTS page
↑ Piano F et al. (2000) RNAi analysis of genes expressed in the ovary of Caenorhabditis elegans. Curr Biol 10: 1619-22 PubMed GONUTS page
↑ Hannak E et al. (2002) The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent. J Cell Biol 157: 591-602 PubMed GONUTS page
↑ Tsou MF et al. (2002) LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues in C. elegans embryos. Development 129: 4469-81 PubMed GONUTS page
↑ Simmer F et al. (2003) Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol 1: E12 PubMed GONUTS page
↑ ^15.0 ^15.1 Sönnichsen B et al. (2005) Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature 434: 462-9 PubMed GONUTS page
↑ Ellefson ML & McNally FJ (2009) Kinesin-1 and cytoplasmic dynein act sequentially to move the meiotic spindle to the oocyte cortex in Caenorhabditis elegans. Mol Biol Cell 20: 2722-30 PubMed GONUTS page
↑ Kimura A & Onami S (2005) Computer simulations and image processing reveal length-dependent pulling force as the primary mechanism for C. elegans male pronuclear migration. Dev Cell 8: 765-75 PubMed GONUTS page
↑ ^18.0 ^18.1 Dorsett M & Schedl T (2009) A role for dynein in the inhibition of germ cell proliferative fate. Mol Cell Biol 29: 6128-39 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Locke CJ et al. (2006) Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res 1120: 23-34 PubMed GONUTS page
↑ Yang HY et al. (2005) Kinesin-1 mediates translocation of the meiotic spindle to the oocyte cortex through KCA-1, a novel cargo adapter. J Cell Biol 169: 447-57 PubMed GONUTS page

[PMID:21529718-0] Green RA et al. (2011) A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell 145: 470-82 PubMed GONUTS page

[PMID:12520011-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Mulder NJ et al. (2003) The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res 31: 315-8 PubMed GONUTS page

[PMID:12654719-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Camon E et al. (2003) The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro. Genome Res 13: 662-72 PubMed GONUTS page

[PMID:11598181-3] 4.0 ^4.1 Yoder JH & Han M (2001) Cytoplasmic dynein light intermediate chain is required for discrete aspects of mitosis in Caenorhabditis elegans. Mol Biol Cell 12: 2921-33 PubMed GONUTS page

[PMID:15616192-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Schmidt DJ et al. (2005) Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations. Mol Biol Cell 16: 1200-12 PubMed GONUTS page

[PMID:19219036-5] 6.0 ^6.1 ^6.2 ^6.3 van der Voet M et al. (2009) NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Nat Cell Biol 11: 269-77 PubMed GONUTS page

[PMID:19635841-6] 7.0 ^7.1 Zhou K et al. (2009) A ZYG-12-dynein interaction at the nuclear envelope defines cytoskeletal architecture in the C. elegans gonad. J Cell Biol 186: 229-41 PubMed GONUTS page

[PMID:15166316-7] 8.0 ^8.1 Skop AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305: 61-6 PubMed GONUTS page

[PMID:11099033-8] 9.0 ^9.1 Fraser AG et al. (2000) Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408: 325-30 PubMed GONUTS page

[PMID:11178279-9] 10.0 ^10.1 Kamath RS et al. (2001) Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol 2: RESEARCH0002 PubMed GONUTS page

[PMID:11137018-10] Piano F et al. (2000) RNAi analysis of genes expressed in the ovary of Caenorhabditis elegans. Curr Biol 10: 1619-22 PubMed GONUTS page

[PMID:12011109-11] Hannak E et al. (2002) The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent. J Cell Biol 157: 591-602 PubMed GONUTS page

[PMID:12223405-12] Tsou MF et al. (2002) LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues in C. elegans embryos. Development 129: 4469-81 PubMed GONUTS page

[PMID:14551910-13] Simmer F et al. (2003) Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol 1: E12 PubMed GONUTS page

[PMID:15791247-14] 15.0 ^15.1 Sönnichsen B et al. (2005) Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature 434: 462-9 PubMed GONUTS page

[PMID:19357192-15] Ellefson ML & McNally FJ (2009) Kinesin-1 and cytoplasmic dynein act sequentially to move the meiotic spindle to the oocyte cortex in Caenorhabditis elegans. Mol Biol Cell 20: 2722-30 PubMed GONUTS page

[PMID:15866166-16] Kimura A & Onami S (2005) Computer simulations and image processing reveal length-dependent pulling force as the primary mechanism for C. elegans male pronuclear migration. Dev Cell 8: 765-75 PubMed GONUTS page

[PMID:19752194-17] 18.0 ^18.1 Dorsett M & Schedl T (2009) A role for dynein in the inhibition of germ cell proliferative fate. Mol Cell Biol 29: 6128-39 PubMed GONUTS page

[PMID:16996038-18] 19.0 ^19.1 ^19.2 ^19.3 Locke CJ et al. (2006) Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res 1120: 23-34 PubMed GONUTS page

[PMID:15883196-19] Yang HY et al. (2005) Kinesin-1 mediates translocation of the meiotic spindle to the oocyte cortex through KCA-1, a novel cargo adapter. J Cell Biol 169: 447-57 PubMed GONUTS page

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Species (Taxon ID)	Caenorhabditis elegans (nematode) (taxon:6239)
Gene Name(s)	dhc-1 ( synonyms: T21E12.4, spd-4 )
Protein Name(s)	No Information Provided.
External Links
WB	WBGene00000962

WB:dhc-1

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