WB:daf-2

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000003	reproduction	WB_REF:WBPaper00003244 PMID:9790527^[1]	IMP: Inferred from Mutant Phenotype	WB:WBVar00088561 WB:WBVar00143949	P	From WB
	GO:0000003	reproduction	WB_REF:WBPaper00005488 PMID:12399591^[2]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00066317	P	From WB
	GO:0004672	protein kinase activity	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR000719	F	From WB
	GO:0004672	protein kinase activity	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR001245	F	From WB
	GO:0004672	protein kinase activity	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR002290	F	From WB
	GO:0004713	protein tyrosine kinase activity	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR008266	F	From WB
	GO:0004713	protein tyrosine kinase activity	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR020635	F	From WB
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR006211	F	From WB
	GO:0005009	insulin-activated receptor activity	WB_REF:WBPaper00002847 PMID:9252323^[5]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	F	From WB
	GO:0005524	ATP binding	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR000719	F	From WB
	GO:0005524	ATP binding	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR002290	F	From WB
	GO:0005524	ATP binding	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR006211	F	From WB
	GO:0005524	ATP binding	WB_REF:WBPaper00002847 PMID:9252323^[5]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	F	From WB
	GO:0006468	protein phosphorylation	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR000719	P	From WB
	GO:0006468	protein phosphorylation	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR001245	P	From WB
	GO:0006468	protein phosphorylation	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR002290	P	From WB
	GO:0006468	protein phosphorylation	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR006211	P	From WB
	GO:0006468	protein phosphorylation	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR008266	P	From WB
	GO:0006468	protein phosphorylation	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR020635	P	From WB
	GO:0006979	response to oxidative stress	WB_REF:WBPaper00005488 PMID:12399591^[2]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00066317	P	From WB
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR006211	P	From WB
	GO:0008286	insulin receptor signaling pathway	WB_REF:WBPaper00002847 PMID:9252323^[5]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00003244 PMID:9790527^[1]	IMP: Inferred from Mutant Phenotype	WB:WBVar00088561 WB:WBVar00143948	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00004702 PMID:11381260^[6]	IMP: Inferred from Mutant Phenotype	WB:WBVar00143949	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00005488 PMID:12399591^[2]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00066317 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00005488 PMID:12399591^[2]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00066319 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00006153 PMID:14576426^[7]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00062549 WB:WBPhenotype:0000039	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00006153 PMID:14576426^[7]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00062550 WB:WBPhenotype:0000039	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00006153 PMID:14576426^[7]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00062551 WB:WBPhenotype:0000039	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00026715 PMID:16103914^[8]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00063999 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00026715 PMID:16103914^[8]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00064000 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00026793 PMID:16151516^[9]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00063892 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00027682 PMID:16777605^[10]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00066518 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00029254 PMID:17411345^[11]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00066137 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00030797 PMID:17571923^[12]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00066316 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00030830 PMID:17608836^[13]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00078529 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00032062 PMID:18662544^[14]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00077707 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00033115 PMID:19372390^[15]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00084294 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00033115 PMID:19372390^[15]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00084297 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00033115 PMID:19372390^[15]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00084301 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00033115 PMID:19372390^[15]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00084302 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00033449 PMID:19506556^[16]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00084323 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00033449 PMID:19506556^[16]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00084331 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00035083 PMID:19675139^[17]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00081713 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00035083 PMID:19675139^[17]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00081714 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00035204 PMID:19747231^[18]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00079036 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00036348 PMID:20523893^[19]	IGI: Inferred from Genetic Interaction	WB:WBGene00006414	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00037741 PMID:21040400^[20]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00084922 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00037741 PMID:21040400^[20]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00084923 WB:WBPhenotype:0000061	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00037855 PMID:21129974^[21]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00086039 WB:WBPhenotype:0000039	P	From WB
	GO:0008340	determination of adult lifespan	WB_REF:WBPaper00037855 PMID:21129974^[21]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00086040 WB:WBPhenotype:0000039	P	From WB
	GO:0009408	response to heat	WB_REF:WBPaper00029007 PMID:17266680^[22]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00075694 WB:WBPhenotype:0001273	P	From WB
	GO:0016020	membrane	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR000494	C	From WB
	GO:0016020	membrane	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	INTERPRO:IPR006211	C	From WB
	GO:0016021	integral to membrane	PMID:12520011^[3] PMID:12654719^[4]	IEA: Inferred from Electronic Annotation	CBS:TMHMM	C	From WB
	GO:0017046	peptide hormone binding	WB_REF:WBPaper00002847 PMID:9252323^[5]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	F	From WB
	GO:0019915	lipid storage	WB_REF:WBPaper00029254 PMID:17411345^[11]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00066265 WB:WBPhenotype:0001184	P	From WB
	GO:0019915	lipid storage	WB_REF:WBPaper00036254 PMID:20461074^[23]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00084700 WB:WBPhenotype:0001184	P	From WB
	GO:0040011	locomotion	WB_REF:WBPaper00006153 PMID:14576426^[7]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00062551 WB:WBPhenotype:0000643	P	From WB
	GO:0040024	dauer larval development	WB_REF:WBPaper00002847 PMID:9252323^[5]	IMP: Inferred from Mutant Phenotype	WB:WBVar00088892 WB:WBVar00143945 WB:WBVar00143947 WB:WBVar00143949 WB:WBVar00143967 WB:WBVar00242507 WB:WBVar00242527 WB:WBVar00242531	P	From WB
	GO:0040024	dauer larval development	WB_REF:WBPaper00003244 PMID:9790527^[1]	IMP: Inferred from Mutant Phenotype	WB:WBVar00088561 WB:WBVar00143948 WB:WBVar00143949	P	From WB
	GO:0040024	dauer larval development	WB_REF:WBPaper00003883 PMID:10625546^[24]	IMP: Inferred from Mutant Phenotype	WB:WBVar00143949	P	From WB
	GO:0040024	dauer larval development	WB_REF:WBPaper00004702 PMID:11381260^[6]	IMP: Inferred from Mutant Phenotype	WB:WBVar00143949	P	From WB
	GO:0040034	regulation of development, heterochronic	WB_REF:WBPaper00038300 PMID:21471153^[25]	IGI: Inferred from Genetic Interaction	WB:WBGene00000105	P	From WB
	GO:0040034	regulation of development, heterochronic	WB_REF:WBPaper00038300 PMID:21471153^[25]	IGI: Inferred from Genetic Interaction	WB:WBGene00000908	P	From WB
	GO:0040034	regulation of development, heterochronic	WB_REF:WBPaper00038300 PMID:21471153^[25]	IGI: Inferred from Genetic Interaction	WB:WBGene00004751	P	From WB
	GO:0042169	SH2 domain binding	WB_REF:WBPaper00002847 PMID:9252323^[5]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	F	From WB
	GO:0042992	negative regulation of transcription factor import into nucleus	WB_REF:WBPaper00004702 PMID:11381260^[6]	IGI: Inferred from Genetic Interaction	WB:WBGene00000912	P	From WB
	GO:0042992	negative regulation of transcription factor import into nucleus	WB_REF:WBPaper00031617 PMID:18358814^[26]	IMP: Inferred from Mutant Phenotype	WB:WBVar00143947 WB:WBVar00143949	P	From WB
	GO:0043053	dauer entry	WB_REF:WBPaper00005488 PMID:12399591^[2]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00066317 WB:WBPhenotype:0000637	P	From WB
	GO:0043053	dauer entry	WB_REF:WBPaper00006153 PMID:14576426^[7]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00062551 WB:WBPhenotype:0000637	P	From WB
	GO:0043053	dauer entry	WB_REF:WBPaper00006382 PMID:14961122^[27]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00063123 WB:WBPhenotype:0000637	P	From WB
	GO:0043053	dauer entry	WB_REF:WBPaper00031230 PMID:18025456^[28]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00069848 WB:WBPhenotype:0000637	P	From WB
	GO:0043053	dauer entry	WB_REF:WBPaper00031230 PMID:18025456^[28]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00069849 WB:WBPhenotype:0000637	P	From WB
	GO:0043053	dauer entry	WB_REF:WBPaper00031230 PMID:18025456^[28]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00069850 WB:WBPhenotype:0000637	P	From WB
	GO:0043054	dauer exit	WB_REF:WBPaper00003244 PMID:9790527^[1]	IMP: Inferred from Mutant Phenotype	WB:WBVar00088561	P	From WB
	GO:0046777	protein autophosphorylation	WB_REF:WBPaper00002847 PMID:9252323^[5]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P06213	P	From WB
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Apfeld J & Kenyon C (1998) Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span. Cell 95: 199-210 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Dillin A et al. (2002) Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298: 830-4 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 ^3.18 Mulder NJ et al. (2003) The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res 31: 315-8 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 Camon E et al. (2003) The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro. Genome Res 13: 662-72 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Kimura KD et al. (1997) daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942-6 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Lin K et al. (2001) Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet 28: 139-45 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Arantes-Oliveira N et al. (2003) Healthy animals with extreme longevity. Science 302: 611 PubMed GONUTS page
↑ ^8.0 ^8.1 Hansen M et al. (2005) New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet 1: 119-28 PubMed GONUTS page
↑ Raices M et al. (2005) Uncoupling of longevity and telomere length in C. elegans. PLoS Genet 1: e30 PubMed GONUTS page
↑ Berdichevsky A et al. (2006) C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125: 1165-77 PubMed GONUTS page
↑ ^11.0 ^11.1 Curran SP & Ruvkun G (2007) Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet 3: e56 PubMed GONUTS page
↑ Toivonen JM et al. (2007) No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects. PLoS Genet 3: e95 PubMed GONUTS page
↑ Kim Y & Sun H (2007) Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan. Aging Cell 6: 489-503 PubMed GONUTS page
↑ Budovskaya YV et al. (2008) An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell 134: 291-303 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Mehta R et al. (2009) Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324: 1196-8 PubMed GONUTS page
↑ ^16.0 ^16.1 Curran SP et al. (2009) A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature 459: 1079-84 PubMed GONUTS page
↑ ^17.0 ^17.1 Schlotterer A et al. (2009) C. elegans as model for the study of high glucose- mediated life span reduction. Diabetes 58: 2450-6 PubMed GONUTS page
↑ Wu D et al. (2009) Mortality shifts in Caenorhabditis elegans: remembrance of conditions past. Aging Cell 8: 666-75 PubMed GONUTS page
↑ Schreiber MA et al. (2010) Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1. PLoS Genet 6: e1000972 PubMed GONUTS page
↑ ^20.0 ^20.1 Mouchiroud L et al. (2011) Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans. Aging Cell 10: 39-54 PubMed GONUTS page
↑ ^21.0 ^21.1 de Lencastre A et al. (2010) MicroRNAs both promote and antagonize longevity in C. elegans. Curr Biol 20: 2159-68 PubMed GONUTS page
↑ Pan KZ et al. (2007) Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6: 111-9 PubMed GONUTS page
↑ Arda HE et al. (2010) Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network. Mol Syst Biol 6: 367 PubMed GONUTS page
↑ Inoue T & Thomas JH (2000) Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation. Dev Biol 217: 192-204 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Huang X et al. (2011) The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans. Development 138: 2059-68 PubMed GONUTS page
↑ Tullet JM et al. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132: 1025-38 PubMed GONUTS page
↑ Kennedy S et al. (2004) A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature 427: 645-9 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Murphy CT et al. (2007) Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci U S A 104: 19046-50 PubMed GONUTS page

[PMID:9790527-0] 1.0 ^1.1 ^1.2 ^1.3 Apfeld J & Kenyon C (1998) Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span. Cell 95: 199-210 PubMed GONUTS page

[PMID:12399591-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Dillin A et al. (2002) Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298: 830-4 PubMed GONUTS page

[PMID:12520011-2] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 ^3.18 Mulder NJ et al. (2003) The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res 31: 315-8 PubMed GONUTS page

[PMID:12654719-3] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 Camon E et al. (2003) The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro. Genome Res 13: 662-72 PubMed GONUTS page

[PMID:9252323-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Kimura KD et al. (1997) daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942-6 PubMed GONUTS page

[PMID:11381260-5] 6.0 ^6.1 ^6.2 Lin K et al. (2001) Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet 28: 139-45 PubMed GONUTS page

[PMID:14576426-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Arantes-Oliveira N et al. (2003) Healthy animals with extreme longevity. Science 302: 611 PubMed GONUTS page

[PMID:16103914-7] 8.0 ^8.1 Hansen M et al. (2005) New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet 1: 119-28 PubMed GONUTS page

[PMID:16151516-8] Raices M et al. (2005) Uncoupling of longevity and telomere length in C. elegans. PLoS Genet 1: e30 PubMed GONUTS page

[PMID:16777605-9] Berdichevsky A et al. (2006) C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125: 1165-77 PubMed GONUTS page

[PMID:17411345-10] 11.0 ^11.1 Curran SP & Ruvkun G (2007) Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet 3: e56 PubMed GONUTS page

[PMID:17571923-11] Toivonen JM et al. (2007) No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects. PLoS Genet 3: e95 PubMed GONUTS page

[PMID:17608836-12] Kim Y & Sun H (2007) Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan. Aging Cell 6: 489-503 PubMed GONUTS page

[PMID:18662544-13] Budovskaya YV et al. (2008) An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell 134: 291-303 PubMed GONUTS page

[PMID:19372390-14] 15.0 ^15.1 ^15.2 ^15.3 Mehta R et al. (2009) Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324: 1196-8 PubMed GONUTS page

[PMID:19506556-15] 16.0 ^16.1 Curran SP et al. (2009) A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature 459: 1079-84 PubMed GONUTS page

[PMID:19675139-16] 17.0 ^17.1 Schlotterer A et al. (2009) C. elegans as model for the study of high glucose- mediated life span reduction. Diabetes 58: 2450-6 PubMed GONUTS page

[PMID:19747231-17] Wu D et al. (2009) Mortality shifts in Caenorhabditis elegans: remembrance of conditions past. Aging Cell 8: 666-75 PubMed GONUTS page

[PMID:20523893-18] Schreiber MA et al. (2010) Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1. PLoS Genet 6: e1000972 PubMed GONUTS page

[PMID:21040400-19] 20.0 ^20.1 Mouchiroud L et al. (2011) Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans. Aging Cell 10: 39-54 PubMed GONUTS page

[PMID:21129974-20] 21.0 ^21.1 de Lencastre A et al. (2010) MicroRNAs both promote and antagonize longevity in C. elegans. Curr Biol 20: 2159-68 PubMed GONUTS page

[PMID:17266680-21] Pan KZ et al. (2007) Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6: 111-9 PubMed GONUTS page

[PMID:20461074-22] Arda HE et al. (2010) Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network. Mol Syst Biol 6: 367 PubMed GONUTS page

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Species (Taxon ID)	Caenorhabditis elegans (nematode) (taxon:6239)
Gene Name(s)	daf-2 ( synonyms: Y55D5A.5 )
Protein Name(s)	No Information Provided.
External Links
WB	WBGene00000898

WB:daf-2

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