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WB:cdc-42

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Contents

Species (Taxon ID) Caenorhabditis elegans (nematode) (taxon:6239)
Gene Name(s) cdc-42 ( synonyms: R07G3.1 )
Protein Name(s) No Information Provided.
External Links
WB WBGene00000390

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000003

reproduction

WB_REF:WBPaper00005654
PMID:12529635[1]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00009047
WB:WBPhenotype:0001037

P

From WB

GO:0000003

reproduction

WB_REF:WBPaper00024497
PMID:15489339[2]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00034721
WB:WBPhenotype:0000689

P

From WB

GO:0000003

reproduction

WB_REF:WBPaper00027135
PMID:16507136[3]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00068318
WB:WBPhenotype:0000688

P

From WB

GO:0000003

reproduction

WB_REF:WBPaper00027135
PMID:16507136[3]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00068319
WB:WBPhenotype:0000688

P

From WB

GO:0000003

reproduction

WB_REF:WBPaper00027135
PMID:16507136[3]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00068320
WB:WBPhenotype:0000688

P

From WB

GO:0000003

reproduction

WB_REF:WBPaper00027135
PMID:16507136[3]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00068321
WB:WBPhenotype:0000688

P

From WB

GO:0000003

reproduction

WB_REF:WBPaper00027756
PMID:16845399[4]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00064511
WB:WBPhenotype:0000688

P

From WB

GO:0000003

reproduction

WB_REF:WBPaper00027756
PMID:16845399[4]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00064641
WB:WBPhenotype:0000688

P

From WB

GO:0000003

reproduction

WB_REF:WBPaper00027756
PMID:16845399[4]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00064702
WB:WBPhenotype:0000688

P

From WB

GO:0000003

reproduction

WB_REF:WBPaper00027756
PMID:16845399[4]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00064793
WB:WBPhenotype:0000688

P

From WB

GO:0000132

establishment of mitotic spindle orientation

WB_REF:WBPaper00004725
PMID:11412997[5]

IMP: Inferred from Mutant Phenotype

P

From WB

GO:0000910

cytokinesis

WB_REF:WBPaper00004654
PMID:11412996[6]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00078508
WB:WBPhenotype:0001018

P

From WB

GO:0002119

nematode larval development

WB_REF:WBPaper00006395
PMID:14551910[7]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00026057
WB:WBPhenotype:0000059

P

From WB

GO:0003924

GTPase activity

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR020849

F

From WB

GO:0003924

GTPase activity

WB_REF:WBPaper00001744
PMID:8514766[10]

IDA: Inferred from Direct Assay

F

From WB

GO:0003924

GTPase activity

WB_REF:WBPaper00001744
PMID:8514766[10]

ISS: Inferred from Sequence or Structural Similarity

F

From WB

GO:0003924

GTPase activity

WB_REF:WBPaper00025137
PMID:15659649[11]

IDA: Inferred from Direct Assay

F

From WB

GO:0003924

GTPase activity

WB_REF:WBPaper00027071
PMID:15814614[12]

IDA: Inferred from Direct Assay

F

From WB

GO:0003924

GTPase activity

WB_REF:WBPaper00031005
PMID:17848508[13]

IDA: Inferred from Direct Assay

F

From WB

GO:0005525

GTP binding

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR001806

F

From WB

GO:0005525

GTP binding

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR003578

F

From WB

GO:0005525

GTP binding

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR003579

F

From WB

GO:0005525

GTP binding

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR005225

F

From WB

GO:0005525

GTP binding

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR013684

F

From WB

GO:0005525

GTP binding

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR020849

F

From WB

GO:0005525

GTP binding

WB_REF:WBPaper00027071
PMID:15814614[12]

IDA: Inferred from Direct Assay

F

From WB

GO:0005622

intracellular

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR003578

C

From WB

GO:0005622

intracellular

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR013684

C

From WB

GO:0005626

insoluble fraction

WB_REF:WBPaper00002544
PMID:8824291[14]

IDA: Inferred from Direct Assay

C

From WB

GO:0005737

cytoplasm

WB_REF:WBPaper00028526
PMID:16996049[15]

IDA: Inferred from Direct Assay

C

From WB

GO:0005813

centrosome

WB_REF:WBPaper00028526
PMID:16996049[15]

IDA: Inferred from Direct Assay

C

From WB

GO:0005886

plasma membrane

WB_REF:WBPaper00002544
PMID:8824291[14]

IDA: Inferred from Direct Assay

C

From WB

GO:0005938

cell cortex

WB_REF:WBPaper00028526
PMID:16996049[15]

IDA: Inferred from Direct Assay

C

From WB

GO:0006184

GTP catabolic process

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR020849

P

From WB

GO:0006184

GTP catabolic process

WB_REF:WBPaper00001744
PMID:8514766[10]

IDA: Inferred from Direct Assay

P

From WB

GO:0006184

GTP catabolic process

WB_REF:WBPaper00025137
PMID:15659649[11]

IDA: Inferred from Direct Assay

P

From WB

GO:0006898

receptor-mediated endocytosis

WB_REF:WBPaper00030951
PMID:17704769[16]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00071164
WB:WBPhenotype:0001425

P

From WB

GO:0007163

establishment or maintenance of cell polarity

WB_REF:WBPaper00004725
PMID:11412997[5]

IMP: Inferred from Mutant Phenotype

P

From WB

GO:0007165

signal transduction

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR020849

P

From WB

GO:0007264

small GTPase mediated signal transduction

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR001806

P

From WB

GO:0007264

small GTPase mediated signal transduction

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR003578

P

From WB

GO:0007264

small GTPase mediated signal transduction

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR003579

P

From WB

GO:0007264

small GTPase mediated signal transduction

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR013684

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00004654
PMID:11412996[6]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00004993
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00004654
PMID:11412996[6]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00078508
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00004725
PMID:11412997[5]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00004999
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00005654
PMID:12529635[1]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00009047
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00006395
PMID:14551910[7]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00026057
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00024200
PMID:15166316[17]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00080528
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00025054
PMID:15791247[18]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00051498
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00027756
PMID:16845399[4]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00064511
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00027756
PMID:16845399[4]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00064625
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00027756
PMID:16845399[4]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00064641
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00027756
PMID:16845399[4]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00064793
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00027756
PMID:16845399[4]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00064817
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00028408
PMID:16921365[19]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00065654
WB:WBPhenotype:0000050

P

From WB

GO:0010171

body morphogenesis

WB_REF:WBPaper00005654
PMID:12529635[1]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00009047
WB:WBPhenotype:0000535

P

From WB

GO:0015031

protein transport

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR003579

P

From WB

GO:0016020

membrane

PMID:12520011[8]
PMID:12654719[9]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR020849

C

From WB

GO:0016477

cell migration

WB_REF:WBpaper00026850
PMID:16213217[20]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00062774
WB:WBPhenotype:0000594

P

From WB

GO:0016477

cell migration

WB_REF:WBpaper00026850
PMID:16213217[20]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00062775
WB:WBPhenotype:0000594

P

From WB

GO:0032970

regulation of actin filament-based process

WB_REF:WBPaper00031005
PMID:17848508[13]

IMP: Inferred from Mutant Phenotype

P

From WB

GO:0040002

collagen and cuticulin-based cuticle development

WB_REF:WBPaper00024497
PMID:15489339[2]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00034721
WB:WBPhenotype:0000025

P

From WB

GO:0040007

growth

WB_REF:WBPaper00006395
PMID:14551910[7]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00026057
WB:WBPhenotype:0000059

P

From WB

GO:0040011

locomotion

WB_REF:WBPaper00006395
PMID:14551910[7]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00026057
WB:WBPhenotype:0000643

P

From WB

GO:0040011

locomotion

WB_REF:WBPaper00026657
PMID:16055082[21]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00061131
WB:WBPhenotype:0000643

P

From WB

GO:0040027

negative regulation of vulval development

WB_REF:WBPaper00005654
PMID:12529635[1]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00009047
WB:WBPhenotype:0000700

P

From WB

GO:0040027

negative regulation of vulval development

WB_REF:WBPaper00024497
PMID:15489339[2]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00034721
WB:WBPhenotype:0000700

P

From WB

GO:0040035

hermaphrodite genitalia development

WB_REF:WBPaper00024497
PMID:15489339[2]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00034721
WB:WBPhenotype:0000697

P

From WB

GO:0040039

inductive cell migration

WB_REF:WBPaper00028783
PMID:17090602[22]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00065748
WB:WBPhenotype:0000195

P

From WB

GO:0048471

perinuclear region of cytoplasm

WB_REF:WBPaper00028526
PMID:16996049[15]

IDA: Inferred from Direct Assay

C

From WB

GO:0055037

recycling endosome

WB_REF:WBPaper00030951
PMID:17704769[16]

IDA: Inferred from Direct Assay

C

From WB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 Kamath RS et al. (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421: 231-7 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Rual JF et al. (2004) Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res 14: 2162-8 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Lehner B et al. (2006) Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference. Genome Biol 7: R4 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 Lehner B et al. (2006) Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Nat Genet 38: 896-903 PubMed GONUTS page
  5. 5.0 5.1 5.2 Gotta M et al. (2001) CDC-42 controls early cell polarity and spindle orientation in C. elegans. Curr Biol 11: 482-8 PubMed GONUTS page
  6. 6.0 6.1 6.2 Kay AJ & Hunter CP (2001) CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans. Curr Biol 11: 474-81 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Simmer F et al. (2003) Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol 1: E12 PubMed GONUTS page
  8. 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 8.14 8.15 8.16 Mulder NJ et al. (2003) The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res 31: 315-8 PubMed GONUTS page
  9. 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 9.11 9.12 9.13 9.14 9.15 9.16 Camon E et al. (2003) The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro. Genome Res 13: 662-72 PubMed GONUTS page
  10. 10.0 10.1 10.2 Chen W et al. (1993) The CDC42 homologue from Caenorhabditis elegans. Complementation of yeast mutation. J Biol Chem 268: 13280-5 PubMed GONUTS page
  11. 11.0 11.1 Jenna S et al. (2005) Regulation of membrane trafficking by a novel Cdc42-related protein in Caenorhabditis elegans epithelial cells. Mol Biol Cell 16: 1629-39 PubMed GONUTS page
  12. 12.0 12.1 Caruso ME et al. (2005) Biochemical clustering of monomeric GTPases of the Ras superfamily. Mol Cell Proteomics 4: 936-44 PubMed GONUTS page
  13. 13.0 13.1 Schonegg S et al. (2007) The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos. Proc Natl Acad Sci U S A 104: 14976-81 PubMed GONUTS page
  14. 14.0 14.1 Chen W et al. (1996) The Caenorhabditis elegans p21-activated kinase (CePAK) colocalizes with CeRac1 and CDC42Ce at hypodermal cell boundaries during embryo elongation. J Biol Chem 271: 26362-8 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 Aceto D et al. (2006) Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans. Dev Biol 299: 386-97 PubMed GONUTS page
  16. 16.0 16.1 Balklava Z et al. (2007) Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic. Nat Cell Biol 9: 1066-73 PubMed GONUTS page
  17. Skop AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305: 61-6 PubMed GONUTS page
  18. Sönnichsen B et al. (2005) Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature 434: 462-9 PubMed GONUTS page
  19. Motegi F & Sugimoto A (2006) Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos. Nat Cell Biol 8: 978-85 PubMed GONUTS page
  20. 20.0 20.1 Norman KR et al. (2005) The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans. Cell 123: 119-32 PubMed GONUTS page
  21. Hikita T et al. (2005) Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure. Biochem Biophys Res Commun 335: 139-45 PubMed GONUTS page
  22. Cram EJ et al. (2006) A systematic RNA interference screen reveals a cell migration gene network in C. elegans. J Cell Sci 119: 4811-8 PubMed GONUTS page
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