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WB:cdc-42
Contents |
| Species (Taxon ID) | Caenorhabditis elegans (nematode) (taxon:6239) | |
| Gene Name(s) | cdc-42 ( synonyms: R07G3.1 ) | |
| Protein Name(s) | No Information Provided. | |
| External Links | ||
| WB | WBGene00000390 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000003 |
reproduction |
WB_REF:WBPaper00005654 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00009047 |
P |
From WB |
||
| GO:0000003 |
reproduction |
WB_REF:WBPaper00024497 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00034721 |
P |
From WB |
||
| GO:0000003 |
reproduction |
WB_REF:WBPaper00027135 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00068318 |
P |
From WB |
||
| GO:0000003 |
reproduction |
WB_REF:WBPaper00027135 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00068319 |
P |
From WB |
||
| GO:0000003 |
reproduction |
WB_REF:WBPaper00027135 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00068320 |
P |
From WB |
||
| GO:0000003 |
reproduction |
WB_REF:WBPaper00027135 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00068321 |
P |
From WB |
||
| GO:0000003 |
reproduction |
WB_REF:WBPaper00027756 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00064511 |
P |
From WB |
||
| GO:0000003 |
reproduction |
WB_REF:WBPaper00027756 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00064641 |
P |
From WB |
||
| GO:0000003 |
reproduction |
WB_REF:WBPaper00027756 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00064702 |
P |
From WB |
||
| GO:0000003 |
reproduction |
WB_REF:WBPaper00027756 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00064793 |
P |
From WB |
||
| GO:0000132 |
establishment of mitotic spindle orientation |
WB_REF:WBPaper00004725 |
IMP: Inferred from Mutant Phenotype |
P |
From WB |
|||
| GO:0000910 |
cytokinesis |
WB_REF:WBPaper00004654 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00078508 |
P |
From WB |
||
| GO:0002119 |
nematode larval development |
WB_REF:WBPaper00006395 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00026057 |
P |
From WB |
||
| GO:0003924 |
GTPase activity |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR020849 |
F |
From WB |
|||
| GO:0003924 |
GTPase activity |
WB_REF:WBPaper00001744 |
IDA: Inferred from Direct Assay |
F |
From WB |
|||
| GO:0003924 |
GTPase activity |
WB_REF:WBPaper00001744 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From WB |
|||
| GO:0003924 |
GTPase activity |
WB_REF:WBPaper00025137 |
IDA: Inferred from Direct Assay |
F |
From WB |
|||
| GO:0003924 |
GTPase activity |
WB_REF:WBPaper00027071 |
IDA: Inferred from Direct Assay |
F |
From WB |
|||
| GO:0003924 |
GTPase activity |
WB_REF:WBPaper00031005 |
IDA: Inferred from Direct Assay |
F |
From WB |
|||
| GO:0005525 |
GTP binding |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR001806 |
F |
From WB |
|||
| GO:0005525 |
GTP binding |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR003578 |
F |
From WB |
|||
| GO:0005525 |
GTP binding |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR003579 |
F |
From WB |
|||
| GO:0005525 |
GTP binding |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR005225 |
F |
From WB |
|||
| GO:0005525 |
GTP binding |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR013684 |
F |
From WB |
|||
| GO:0005525 |
GTP binding |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR020849 |
F |
From WB |
|||
| GO:0005525 |
GTP binding |
WB_REF:WBPaper00027071 |
IDA: Inferred from Direct Assay |
F |
From WB |
|||
| GO:0005622 |
intracellular |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR003578 |
C |
From WB |
|||
| GO:0005622 |
intracellular |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR013684 |
C |
From WB |
|||
| GO:0005626 |
insoluble fraction |
WB_REF:WBPaper00002544 |
IDA: Inferred from Direct Assay |
C |
From WB |
|||
| GO:0005737 |
cytoplasm |
WB_REF:WBPaper00028526 |
IDA: Inferred from Direct Assay |
C |
From WB |
|||
| GO:0005813 |
centrosome |
WB_REF:WBPaper00028526 |
IDA: Inferred from Direct Assay |
C |
From WB |
|||
| GO:0005886 |
plasma membrane |
WB_REF:WBPaper00002544 |
IDA: Inferred from Direct Assay |
C |
From WB |
|||
| GO:0005938 |
cell cortex |
WB_REF:WBPaper00028526 |
IDA: Inferred from Direct Assay |
C |
From WB |
|||
| GO:0006184 |
GTP catabolic process |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR020849 |
P |
From WB |
|||
| GO:0006184 |
GTP catabolic process |
WB_REF:WBPaper00001744 |
IDA: Inferred from Direct Assay |
P |
From WB |
|||
| GO:0006184 |
GTP catabolic process |
WB_REF:WBPaper00025137 |
IDA: Inferred from Direct Assay |
P |
From WB |
|||
| GO:0006898 |
receptor-mediated endocytosis |
WB_REF:WBPaper00030951 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00071164 |
P |
From WB |
||
| GO:0007163 |
establishment or maintenance of cell polarity |
WB_REF:WBPaper00004725 |
IMP: Inferred from Mutant Phenotype |
P |
From WB |
|||
| GO:0007165 |
signal transduction |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR020849 |
P |
From WB |
|||
| GO:0007264 |
small GTPase mediated signal transduction |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR001806 |
P |
From WB |
|||
| GO:0007264 |
small GTPase mediated signal transduction |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR003578 |
P |
From WB |
|||
| GO:0007264 |
small GTPase mediated signal transduction |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR003579 |
P |
From WB |
|||
| GO:0007264 |
small GTPase mediated signal transduction |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR013684 |
P |
From WB |
|||
| GO:0009792 |
embryo development ending in birth or egg hatching |
WB_REF:WBPaper00004654 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00004993 |
P |
From WB |
||
| GO:0009792 |
embryo development ending in birth or egg hatching |
WB_REF:WBPaper00004654 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00078508 |
P |
From WB |
||
| GO:0009792 |
embryo development ending in birth or egg hatching |
WB_REF:WBPaper00004725 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00004999 |
P |
From WB |
||
| GO:0009792 |
embryo development ending in birth or egg hatching |
WB_REF:WBPaper00005654 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00009047 |
P |
From WB |
||
| GO:0009792 |
embryo development ending in birth or egg hatching |
WB_REF:WBPaper00006395 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00026057 |
P |
From WB |
||
| GO:0009792 |
embryo development ending in birth or egg hatching |
WB_REF:WBPaper00024200 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00080528 |
P |
From WB |
||
| GO:0009792 |
embryo development ending in birth or egg hatching |
WB_REF:WBPaper00025054 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00051498 |
P |
From WB |
||
| GO:0009792 |
embryo development ending in birth or egg hatching |
WB_REF:WBPaper00027756 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00064511 |
P |
From WB |
||
| GO:0009792 |
embryo development ending in birth or egg hatching |
WB_REF:WBPaper00027756 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00064625 |
P |
From WB |
||
| GO:0009792 |
embryo development ending in birth or egg hatching |
WB_REF:WBPaper00027756 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00064641 |
P |
From WB |
||
| GO:0009792 |
embryo development ending in birth or egg hatching |
WB_REF:WBPaper00027756 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00064793 |
P |
From WB |
||
| GO:0009792 |
embryo development ending in birth or egg hatching |
WB_REF:WBPaper00027756 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00064817 |
P |
From WB |
||
| GO:0009792 |
embryo development ending in birth or egg hatching |
WB_REF:WBPaper00028408 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00065654 |
P |
From WB |
||
| GO:0010171 |
body morphogenesis |
WB_REF:WBPaper00005654 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00009047 |
P |
From WB |
||
| GO:0015031 |
protein transport |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR003579 |
P |
From WB |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
INTERPRO:IPR020849 |
C |
From WB |
|||
| GO:0016477 |
cell migration |
WB_REF:WBpaper00026850 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00062774 |
P |
From WB |
||
| GO:0016477 |
cell migration |
WB_REF:WBpaper00026850 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00062775 |
P |
From WB |
||
| GO:0032970 |
regulation of actin filament-based process |
WB_REF:WBPaper00031005 |
IMP: Inferred from Mutant Phenotype |
P |
From WB |
|||
| GO:0040002 |
collagen and cuticulin-based cuticle development |
WB_REF:WBPaper00024497 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00034721 |
P |
From WB |
||
| GO:0040007 |
growth |
WB_REF:WBPaper00006395 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00026057 |
P |
From WB |
||
| GO:0040011 |
locomotion |
WB_REF:WBPaper00006395 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00026057 |
P |
From WB |
||
| GO:0040011 |
locomotion |
WB_REF:WBPaper00026657 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00061131 |
P |
From WB |
||
| GO:0040027 |
negative regulation of vulval development |
WB_REF:WBPaper00005654 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00009047 |
P |
From WB |
||
| GO:0040027 |
negative regulation of vulval development |
WB_REF:WBPaper00024497 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00034721 |
P |
From WB |
||
| GO:0040035 |
hermaphrodite genitalia development |
WB_REF:WBPaper00024497 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00034721 |
P |
From WB |
||
| GO:0040039 |
inductive cell migration |
WB_REF:WBPaper00028783 |
IMP: Inferred from Mutant Phenotype |
WB:WBRNAi00065748 |
P |
From WB |
||
| GO:0048471 |
perinuclear region of cytoplasm |
WB_REF:WBPaper00028526 |
IDA: Inferred from Direct Assay |
C |
From WB |
|||
| GO:0055037 |
recycling endosome |
WB_REF:WBPaper00030951 |
IDA: Inferred from Direct Assay |
C |
From WB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Kamath RS et al. (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421: 231-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Rual JF et al. (2004) Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res 14: 2162-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Lehner B et al. (2006) Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference. Genome Biol 7: R4 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 Lehner B et al. (2006) Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Nat Genet 38: 896-903 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Gotta M et al. (2001) CDC-42 controls early cell polarity and spindle orientation in C. elegans. Curr Biol 11: 482-8 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Kay AJ & Hunter CP (2001) CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans. Curr Biol 11: 474-81 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Simmer F et al. (2003) Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol 1: E12 PubMed GONUTS page
- ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 8.14 8.15 8.16 Mulder NJ et al. (2003) The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res 31: 315-8 PubMed GONUTS page
- ↑ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 9.11 9.12 9.13 9.14 9.15 9.16 Camon E et al. (2003) The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro. Genome Res 13: 662-72 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Chen W et al. (1993) The CDC42 homologue from Caenorhabditis elegans. Complementation of yeast mutation. J Biol Chem 268: 13280-5 PubMed GONUTS page
- ↑ 11.0 11.1 Jenna S et al. (2005) Regulation of membrane trafficking by a novel Cdc42-related protein in Caenorhabditis elegans epithelial cells. Mol Biol Cell 16: 1629-39 PubMed GONUTS page
- ↑ 12.0 12.1 Caruso ME et al. (2005) Biochemical clustering of monomeric GTPases of the Ras superfamily. Mol Cell Proteomics 4: 936-44 PubMed GONUTS page
- ↑ 13.0 13.1 Schonegg S et al. (2007) The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos. Proc Natl Acad Sci U S A 104: 14976-81 PubMed GONUTS page
- ↑ 14.0 14.1 Chen W et al. (1996) The Caenorhabditis elegans p21-activated kinase (CePAK) colocalizes with CeRac1 and CDC42Ce at hypodermal cell boundaries during embryo elongation. J Biol Chem 271: 26362-8 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 Aceto D et al. (2006) Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans. Dev Biol 299: 386-97 PubMed GONUTS page
- ↑ 16.0 16.1 Balklava Z et al. (2007) Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic. Nat Cell Biol 9: 1066-73 PubMed GONUTS page
- ↑ Skop AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305: 61-6 PubMed GONUTS page
- ↑ Sönnichsen B et al. (2005) Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature 434: 462-9 PubMed GONUTS page
- ↑ Motegi F & Sugimoto A (2006) Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos. Nat Cell Biol 8: 978-85 PubMed GONUTS page
- ↑ 20.0 20.1 Norman KR et al. (2005) The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans. Cell 123: 119-32 PubMed GONUTS page
- ↑ Hikita T et al. (2005) Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure. Biochem Biophys Res Commun 335: 139-45 PubMed GONUTS page
- ↑ Cram EJ et al. (2006) A systematic RNA interference screen reveals a cell migration gene network in C. elegans. J Cell Sci 119: 4811-8 PubMed GONUTS page