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VIBCH:TOXR

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Contents

Species (Taxon ID) Vibrio cholerae. ([1])
Gene Name(s) toxR
Protein Name(s) Cholera toxin transcriptional activator
External Links
EMBL M21249
AE003852
M58033
M62761
PIR A25970
E82257
RefSeq NP_230630.1
ProteinModelPortal P15795
GeneID 2614237
GenomeReviews AE003852_GR
KEGG vch:VC0984
TIGR VC_0984
HOGENOM HBG625927
OMA FVKTVPK
ProtClustDB CLSK874172
GO GO:0016021
GO:0005622
GO:0005886
GO:0003677
GO:0000156
GO:0006355
GO:0006351
InterPro IPR001867
IPR016032
IPR011991
Gene3D G3DSA:1.10.10.10
Pfam PF00486
SMART SM00862
SUPFAM SSF46894

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000156

two-component response regulator activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001867

F

Seeded From UniProt

GO:0000156

two-component response regulator activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016032

F

Seeded From UniProt

GO:0000160

two-component signal transduction system (phosphorelay)

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001867

P

Seeded From UniProt

GO:0000160

two-component signal transduction system (phosphorelay)

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016032

P

Seeded From UniProt

GO:0000160

two-component signal transduction system (phosphorelay)

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0902

P

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001867

F

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016032

F

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded From UniProt

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016032

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0039

C

Seeded From UniProt

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001867

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016032

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded From UniProt

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded From UniProt

GO:2000145

regulation of cell motility

PMID:12601157[1]

IMP: Inferred from Mutant Phenotype

P

Table 1. Top right of page 2805

complete

GO:2000145

regulation of cell motility

PMID:12601157[1]

IEP: Inferred from Expression Pattern

P

Table 1. Top right of page 2805

complete

GO:0090087

regulation of peptide transport

PMID:12601157[1]

IMP: Inferred from Mutant Phenotype

P

Table 1. Top of page 2805 gives more information about specific pathways.

complete

GO:0090087

regulation of peptide transport

PMID:12601157[1]

IEP: Inferred from Expression Pattern

P

Table 1. Top of page 2805 gives more information about specific pathways.

complete

GO:0010675

regulation of cellular carbohydrate metabolic process

PMID:12601157[1]

IMP: Inferred from Mutant Phenotype

P

Table 1. Top right of page 2805.

complete

GO:0010675

regulation of cellular carbohydrate metabolic process

PMID:12601157[1]

IEP: Inferred from Expression Pattern

P

Table 1. Top right of page 2805.

complete

GO:0000156

two-component response regulator activity

PMID:21542860[2]

IDA: Inferred from Direct Assay

F

figure 1, This suggests the ToxR-V71A mutation affects a region of ToxR that is especially important for ToxR to directly activate the ompU promoter, but less critical when ToxR plays an accessory role with TcpP to activate the toxT promoter

figure 3. Gel-shift assays to assess promoter recognition by various ToxR mutant proteins identified in a random mutagenesis ompU-sacB selection strategy.

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Bina J et al. (2003) ToxR regulon of Vibrio cholerae and its expression in vibrios shed by cholera patients. Proc Natl Acad Sci U S A 100: 2801-6 PubMed GONUTS page
  2. Morgan SJ et al. (2011) The two faces of ToxR: activator of ompU, co-regulator of toxT in Vibrio cholerae. Mol Microbiol 81: 113-28 PubMed GONUTS page
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