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SGD:STE5
Contents |
| Species (Taxon ID) | Saccharomyces cerevisiae (baker's yeast) (taxon:4932) | |
| Gene Name(s) | STE5 ( synonyms: YDR103W, HMD3, NUL3 ) | |
| Protein Name(s) | Pheromone-response scaffold protein that controls the mating decision, | |
| External Links | ||
| SGD | S000002510 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000750 |
pheromone-dependent signal transduction involved in conjugation with cellular fusion |
SGD_REF:S000051962 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0000750 |
pheromone-dependent signal transduction involved in conjugation with cellular fusion |
SGD_REF:S000051962 |
IPI: Inferred from Physical Interaction |
P |
From SGD |
|||
| GO:0001403 |
invasive growth in response to glucose limitation |
SGD_REF:S000082049 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0001934 |
positive regulation of protein phosphorylation |
SGD_REF:S000129764 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0005078 |
MAP-kinase scaffold activity |
SGD_REF:S000050302 |
IPI: Inferred from Physical Interaction |
F |
From SGD |
|||
| GO:0005078 |
MAP-kinase scaffold activity |
SGD_REF:S000051962 |
IPI: Inferred from Physical Interaction |
F |
From SGD |
|||
| GO:0005543 |
phospholipid binding |
SGD_REF:S000086905 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000053527 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005737 |
cytoplasm |
SGD_REF:S000069153 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005737 |
cytoplasm |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From SGD |
||
| GO:0005737 |
cytoplasm |
SGD_REF:S000148671 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0086 |
C |
From SGD |
||
| GO:0005886 |
plasma membrane |
SGD_REF:S000053527 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005886 |
plasma membrane |
SGD_REF:S000120550 |
IMP: Inferred from Mutant Phenotype |
C |
From SGD |
|||
| GO:0008270 |
zinc ion binding |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0010525 |
regulation of transposition, RNA-mediated |
SGD_REF:S000045123 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0019236 |
response to pheromone |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0589 |
P |
From SGD |
||
| GO:0043332 |
mating projection tip |
SGD_REF:S000069153 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0043332 |
mating projection tip |
SGD_REF:S000124519 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0043409 |
negative regulation of MAPK cascade |
SGD_REF:S000114268 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Choi KY et al. (1994) Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 78: 499-512 PubMed GONUTS page
- ↑ Andersson J et al. (2004) Differential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes. EMBO J 23: 2564-76 PubMed GONUTS page
- ↑ Good M et al. (2009) The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell 136: 1085-97 PubMed GONUTS page
- ↑ Printen JA & Sprague GF Jr (1994) Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics 138: 609-19 PubMed GONUTS page
- ↑ Winters MJ et al. (2005) A membrane binding domain in the ste5 scaffold synergizes with gbetagamma binding to control localization and signaling in pheromone response. Mol Cell 20: 21-32 PubMed GONUTS page
- ↑ 6.0 6.1 Pryciak PM & Huntress FA (1998) Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway. Genes Dev 12: 2684-97 PubMed GONUTS page
- ↑ 7.0 7.1 van Drogen F et al. (2001) MAP kinase dynamics in response to pheromones in budding yeast. Nat Cell Biol 3: 1051-9 PubMed GONUTS page
- ↑ Garrenton LS et al. (2006) Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain. Genes Dev 20: 1946-58 PubMed GONUTS page
- ↑ Conte D Jr et al. (1998) Posttranslational regulation of Ty1 retrotransposition by mitogen-activated protein kinase Fus3. Mol Cell Biol 18: 2502-13 PubMed GONUTS page
- ↑ Maeder CI et al. (2007) Spatial regulation of Fus3 MAP kinase activity through a reaction-diffusion mechanism in yeast pheromone signalling. Nat Cell Biol 9: 1319-26 PubMed GONUTS page
- ↑ Bhattacharyya RP et al. (2006) The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway. Science 311: 822-6 PubMed GONUTS page
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