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SGD:SPT16
Contents |
| Species (Taxon ID) | Saccharomyces cerevisiae (baker's yeast) (taxon:4932) | |
| Gene Name(s) | SPT16 ( synonyms: YGL207W, CDC68, SSF1 ) | |
| Protein Name(s) | Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), | |
| External Links | ||
| SGD | S000003175 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000790 |
nuclear chromatin |
SGD_REF:S000054316 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0539 |
C |
From SGD |
||
| GO:0005634 |
nucleus |
SGD_REF:S000148671 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0191 |
C |
From SGD |
||
| GO:0005694 |
chromosome |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0158 |
C |
From SGD |
||
| GO:0005694 |
chromosome |
SGD_REF:S000148671 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0468 |
C |
From SGD |
||
| GO:0006260 |
DNA replication |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0235 |
P |
From SGD |
||
| GO:0006261 |
DNA-dependent DNA replication |
SGD_REF:S000052704 |
IPI: Inferred from Physical Interaction |
SGD:S000005046 |
P |
From SGD |
||
| GO:0006281 |
DNA repair |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0234 |
P |
From SGD |
||
| GO:0006334 |
nucleosome assembly |
SGD_REF:S000074335 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0006334 |
nucleosome assembly |
SGD_REF:S000076495 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0006351 |
transcription, DNA-dependent |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From SGD |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From SGD |
||
| GO:0006368 |
transcription elongation from RNA polymerase II promoter |
SGD_REF:S000071357 |
IPI: Inferred from Physical Interaction |
P |
From SGD |
|||
| GO:0006974 |
response to DNA damage stimulus |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0227 |
P |
From SGD |
||
| GO:0008023 |
transcription elongation factor complex |
SGD_REF:S000071357 |
IPI: Inferred from Physical Interaction |
C |
From SGD |
|||
| GO:0009987 |
cellular process |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0031298 |
replication fork protection complex |
SGD_REF:S000119454 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0034401 |
regulation of transcription by chromatin organization |
SGD_REF:S000131308 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0034724 |
DNA replication-independent nucleosome organization |
SGD_REF:S000131309 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0035101 |
FACT complex |
SGD_REF:S000061420 |
IGI: Inferred from Genetic Interaction |
C |
From SGD |
|||
| GO:0035101 |
FACT complex |
SGD_REF:S000061420 |
IPI: Inferred from Physical Interaction |
C |
From SGD |
|||
| GO:0045899 |
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly |
SGD_REF:S000082428 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0060261 |
positive regulation of transcription initiation from RNA polymerase II promoter |
SGD_REF:S000082428 |
IGI: Inferred from Genetic Interaction |
SGD:S000000950 |
P |
From SGD |
||
| GO:0060261 |
positive regulation of transcription initiation from RNA polymerase II promoter |
SGD_REF:S000130799 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
|
colocalizes_with |
GO:0005658 |
alpha DNA polymerase:primase complex |
SGD_REF:S000054316 |
IDA: Inferred from Direct Assay |
C |
From SGD |
||
|
contributes_to |
GO:0003682 |
chromatin binding |
SGD_REF:S000054316 |
IDA: Inferred from Direct Assay |
F |
From SGD |
||
|
contributes_to |
GO:0031491 |
nucleosome binding |
SGD_REF:S000061420 |
IDA: Inferred from Direct Assay |
F |
From SGD |
||
|
contributes_to |
GO:0042393 |
histone binding |
SGD_REF:S000125070 |
IDA: Inferred from Direct Assay |
F |
From SGD |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Wittmeyer J et al. (1999) Spt16 and Pob3 of Saccharomyces cerevisiae form an essential, abundant heterodimer that is nuclear, chromatin-associated, and copurifies with DNA polymerase alpha. Biochemistry 38: 8961-71 PubMed GONUTS page
- ↑ Wittmeyer J & Formosa T (1997) The Saccharomyces cerevisiae DNA polymerase alpha catalytic subunit interacts with Cdc68/Spt16 and with Pob3, a protein similar to an HMG1-like protein. Mol Cell Biol 17: 4178-90 PubMed GONUTS page
- ↑ Ruone S et al. (2003) Multiple Nhp6 molecules are required to recruit Spt16-Pob3 to form yFACT complexes and to reorganize nucleosomes. J Biol Chem 278: 45288-95 PubMed GONUTS page
- ↑ Rhoades AR et al. (2004) Structural features of nucleosomes reorganized by yeast FACT and its HMG box component, Nhp6. Mol Cell Biol 24: 3907-17 PubMed GONUTS page
- ↑ 5.0 5.1 Krogan NJ et al. (2002) RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol 22: 6979-92 PubMed GONUTS page
- ↑ Gambus A et al. (2006) GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol 8: 358-66 PubMed GONUTS page
- ↑ Jamai A et al. (2009) Histone chaperone spt16 promotes redeposition of the original h3-h4 histones evicted by elongating RNA polymerase. Mol Cell 35: 377-83 PubMed GONUTS page
- ↑ Xin H et al. (2009) yFACT induces global accessibility of nucleosomal DNA without H2A-H2B displacement. Mol Cell 35: 365-76 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Formosa T et al. (2001) Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN. EMBO J 20: 3506-17 PubMed GONUTS page
- ↑ 10.0 10.1 Biswas D et al. (2005) The yeast FACT complex has a role in transcriptional initiation. Mol Cell Biol 25: 5812-22 PubMed GONUTS page
- ↑ Ransom M et al. (2009) FACT and the proteasome promote promoter chromatin disassembly and transcriptional initiation. J Biol Chem 284: 23461-71 PubMed GONUTS page
- ↑ VanDemark AP et al. (2008) Structural and functional analysis of the Spt16p N-terminal domain reveals overlapping roles of yFACT subunits. J Biol Chem 283: 5058-68 PubMed GONUTS page
