SGD:SNF1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From SGD
	GO:0000324	fungal-type vacuole	SGD_REF:S000060188 PMID:11331606^[1]	IPI: Inferred from Physical Interaction		C	From SGD
	GO:0001302	replicative cell aging	SGD_REF:S000049850 PMID:10921902^[2]	IGI: Inferred from Genetic Interaction	SGD:S000002830	P	From SGD
	GO:0001302	replicative cell aging	SGD_REF:S000049850 PMID:10921902^[2]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0001403	invasive growth in response to glucose limitation	SGD_REF:S000059627 PMID:11095711^[3]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0001403	invasive growth in response to glucose limitation	SGD_REF:S000072732 PMID:12556493^[4]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0004672	protein kinase activity	SGD_REF:S000113918 PMID:16319894^[5]	IDA: Inferred from Direct Assay		F	From SGD
	GO:0004672	protein kinase activity	SGD_REF:S000124036	IEA: Inferred from Electronic Annotation	InterPro:IPR002290 InterPro:IPR000719	F	From SGD
	GO:0004674	protein serine/threonine kinase activity	SGD_REF:S000124036	IEA: Inferred from Electronic Annotation	InterPro:IPR013896 InterPro:IPR008271	F	From SGD
	GO:0004674	protein serine/threonine kinase activity	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0723	F	From SGD
	GO:0004679	AMP-activated protein kinase activity	SGD_REF:S000044172 PMID:7913470^[6]	IDA: Inferred from Direct Assay		F	From SGD
	GO:0004679	AMP-activated protein kinase activity	SGD_REF:S000044172 PMID:7913470^[6]	IMP: Inferred from Mutant Phenotype		F	From SGD
	GO:0004679	AMP-activated protein kinase activity	SGD_REF:S000053604 PMID:2557546^[7]	IDA: Inferred from Direct Assay		F	From SGD
	GO:0004679	AMP-activated protein kinase activity	SGD_REF:S000053604 PMID:2557546^[7]	IMP: Inferred from Mutant Phenotype		F	From SGD
	GO:0004679	AMP-activated protein kinase activity	SGD_REF:S000066184 PMID:11486005^[8]	IDA: Inferred from Direct Assay		F	From SGD
	GO:0004679	AMP-activated protein kinase activity	SGD_REF:S000066184 PMID:11486005^[8]	IMP: Inferred from Mutant Phenotype		F	From SGD
	GO:0005524	ATP binding	SGD_REF:S000124036	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR017441 InterPro:IPR002290	F	From SGD
	GO:0005524	ATP binding	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From SGD
	GO:0005634	nucleus	SGD_REF:S000060188 PMID:11331606^[1]	IPI: Inferred from Physical Interaction		C	From SGD
	GO:0005634	nucleus	SGD_REF:S000120464 PMID:17237508^[9]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0005634	nucleus	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0539	C	From SGD
	GO:0005641	nuclear envelope lumen	SGD_REF:S000120464 PMID:17237508^[9]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0005737	cytoplasm	SGD_REF:S000060188 PMID:11331606^[1]	IPI: Inferred from Physical Interaction		C	From SGD
	GO:0005737	cytoplasm	SGD_REF:S000120464 PMID:17237508^[9]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0005739	mitochondrion	SGD_REF:S000075100 PMID:14576278^[10]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0005739	mitochondrion	SGD_REF:S000117178 PMID:16823961^[11]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0005975	carbohydrate metabolic process	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0119	P	From SGD
	GO:0006109	regulation of carbohydrate metabolic process	SGD_REF:S000071682 PMID:12167649^[12]	IGI: Inferred from Genetic Interaction		P	From SGD
	GO:0006109	regulation of carbohydrate metabolic process	SGD_REF:S000071682 PMID:12167649^[12]	IPI: Inferred from Physical Interaction		P	From SGD
	GO:0006109	regulation of carbohydrate metabolic process	SGD_REF:S000071682 PMID:12167649^[12]	TAS: Traceable Author Statement		P	From SGD
	GO:0006468	protein phosphorylation	SGD_REF:S000066184 PMID:11486005^[8]	IDA: Inferred from Direct Assay		P	From SGD
	GO:0006468	protein phosphorylation	SGD_REF:S000113918 PMID:16319894^[5]	IDA: Inferred from Direct Assay		P	From SGD
	GO:0006468	protein phosphorylation	SGD_REF:S000124036	IEA: Inferred from Electronic Annotation	InterPro:IPR008271 InterPro:IPR002290 InterPro:IPR000719	P	From SGD
	GO:0006995	cellular response to nitrogen starvation	SGD_REF:S000070028 PMID:12024013^[13]	IDA: Inferred from Direct Assay		P	From SGD
	GO:0007124	pseudohyphal growth	SGD_REF:S000070028 PMID:12024013^[13]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0007155	cell adhesion	SGD_REF:S000072732 PMID:12556493^[4]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0007165	signal transduction	SGD_REF:S000048626 PMID:10322167^[14]	TAS: Traceable Author Statement		P	From SGD
	GO:0016020	membrane	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From SGD
	GO:0016301	kinase activity	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From SGD
	GO:0016310	phosphorylation	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From SGD
	GO:0016740	transferase activity	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From SGD
	GO:0016772	transferase activity, transferring phosphorus-containing groups	SGD_REF:S000124036	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From SGD
	GO:0017148	negative regulation of translation	SGD_REF:S000128142 PMID:18955495^[15]	IGI: Inferred from Genetic Interaction	SGD:S000002691 SGD:S000001905 SGD:S000000735	P	From SGD
	GO:0017148	negative regulation of translation	SGD_REF:S000128142 PMID:18955495^[15]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0031588	AMP-activated protein kinase complex	SGD_REF:S000046049 PMID:2481228^[16]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0031588	AMP-activated protein kinase complex	SGD_REF:S000046049 PMID:2481228^[16]	IPI: Inferred from Physical Interaction	SGD:S000003083	C	From SGD
	GO:0031588	AMP-activated protein kinase complex	SGD_REF:S000051240 PMID:9121458^[17]	IPI: Inferred from Physical Interaction	SGD:S000003083 SGD:S000003176 SGD:S000002830 SGD:S000000829	C	From SGD
	GO:0031588	AMP-activated protein kinase complex	SGD_REF:S000071984 PMID:12393914^[18]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0031965	nuclear membrane	SGD_REF:S000148671	IEA: Inferred from Electronic Annotation	UniProtKB-SubCell:SL-0182	C	From SGD
	GO:0042710	biofilm formation	SGD_REF:S000070028 PMID:12024013^[13]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0045722	positive regulation of gluconeogenesis	SGD_REF:S000046326 PMID:8628258^[19]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0045722	positive regulation of gluconeogenesis	SGD_REF:S000047272 PMID:9111319^[20]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0045722	positive regulation of gluconeogenesis	SGD_REF:S000054206 PMID:8710504^[21]	IMP: Inferred from Mutant Phenotype		P	From SGD
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Vincent O et al. (2001) Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism. Genes Dev 15: 1104-14 PubMed GONUTS page
↑ ^2.0 ^2.1 Ashrafi K et al. (2000) Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. Genes Dev 14: 1872-85 PubMed GONUTS page
↑ Cullen PJ & Sprague GF Jr (2000) Glucose depletion causes haploid invasive growth in yeast. Proc Natl Acad Sci U S A 97: 13619-24 PubMed GONUTS page
↑ ^4.0 ^4.1 Vyas VK et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23: 1341-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Ptacek J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438: 679-84 PubMed GONUTS page
↑ ^6.0 ^6.1 Woods A et al. (1994) Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. J Biol Chem 269: 19509-15 PubMed GONUTS page
↑ ^7.0 ^7.1 Celenza JL & Carlson M (1989) Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 protein. Mol Cell Biol 9: 5034-44 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 McCartney RR & Schmidt MC (2001) Regulation of Snf1 kinase. Activation requires phosphorylation of threonine 210 by an upstream kinase as well as a distinct step mediated by the Snf4 subunit. J Biol Chem 276: 36460-6 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Sarma NJ et al. (2007) Glucose-responsive regulators of gene expression in Saccharomyces cerevisiae function at the nuclear periphery via a reverse recruitment mechanism. Genetics 175: 1127-35 PubMed GONUTS page
↑ Sickmann A et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100: 13207-12 PubMed GONUTS page
↑ Reinders J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5: 1543-54 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Young ET et al. (2002) Snf1 protein kinase regulates Adr1 binding to chromatin but not transcription activation. J Biol Chem 277: 38095-103 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Kuchin S et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22: 3994-4000 PubMed GONUTS page
↑ Carlson M (1999) Glucose repression in yeast. Curr Opin Microbiol 2: 202-7 PubMed GONUTS page
↑ ^15.0 ^15.1 Shirra MK et al. (2008) A chemical genomics study identifies Snf1 as a repressor of GCN4 translation. J Biol Chem 283: 35889-98 PubMed GONUTS page
↑ ^16.0 ^16.1 Celenza JL et al. (1989) Molecular analysis of the SNF4 gene of Saccharomyces cerevisiae: evidence for physical association of the SNF4 protein with the SNF1 protein kinase. Mol Cell Biol 9: 5045-54 PubMed GONUTS page
↑ Jiang R & Carlson M (1997) The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex. Mol Cell Biol 17: 2099-106 PubMed GONUTS page
↑ Nath N et al. (2002) Purification and characterization of Snf1 kinase complexes containing a defined Beta subunit composition. J Biol Chem 277: 50403-8 PubMed GONUTS page
↑ Lesage P et al. (1996) Yeast SNF1 protein kinase interacts with SIP4, a C6 zinc cluster transcriptional activator: a new role for SNF1 in the glucose response. Mol Cell Biol 16: 1921-8 PubMed GONUTS page
↑ Randez-Gil F et al. (1997) Glucose derepression of gluconeogenic enzymes in Saccharomyces cerevisiae correlates with phosphorylation of the gene activator Cat8p. Mol Cell Biol 17: 2502-10 PubMed GONUTS page
↑ Rahner A et al. (1996) Dual influence of the yeast Cat1p (Snf1p) protein kinase on carbon source-dependent transcriptional activation of gluconeogenic genes by the regulatory gene CAT8. Nucleic Acids Res 24: 2331-7 PubMed GONUTS page

[PMID:11331606-0] 1.0 ^1.1 ^1.2 Vincent O et al. (2001) Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism. Genes Dev 15: 1104-14 PubMed GONUTS page

[PMID:10921902-1] 2.0 ^2.1 Ashrafi K et al. (2000) Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. Genes Dev 14: 1872-85 PubMed GONUTS page

[PMID:11095711-2] Cullen PJ & Sprague GF Jr (2000) Glucose depletion causes haploid invasive growth in yeast. Proc Natl Acad Sci U S A 97: 13619-24 PubMed GONUTS page

[PMID:12556493-3] 4.0 ^4.1 Vyas VK et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23: 1341-8 PubMed GONUTS page

[PMID:16319894-4] 5.0 ^5.1 Ptacek J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438: 679-84 PubMed GONUTS page

[PMID:7913470-5] 6.0 ^6.1 Woods A et al. (1994) Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. J Biol Chem 269: 19509-15 PubMed GONUTS page

[PMID:2557546-6] 7.0 ^7.1 Celenza JL & Carlson M (1989) Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 protein. Mol Cell Biol 9: 5034-44 PubMed GONUTS page

[PMID:11486005-7] 8.0 ^8.1 ^8.2 McCartney RR & Schmidt MC (2001) Regulation of Snf1 kinase. Activation requires phosphorylation of threonine 210 by an upstream kinase as well as a distinct step mediated by the Snf4 subunit. J Biol Chem 276: 36460-6 PubMed GONUTS page

[PMID:17237508-8] 9.0 ^9.1 ^9.2 Sarma NJ et al. (2007) Glucose-responsive regulators of gene expression in Saccharomyces cerevisiae function at the nuclear periphery via a reverse recruitment mechanism. Genetics 175: 1127-35 PubMed GONUTS page

[PMID:14576278-9] Sickmann A et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100: 13207-12 PubMed GONUTS page

[PMID:16823961-10] Reinders J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5: 1543-54 PubMed GONUTS page

[PMID:12167649-11] 12.0 ^12.1 ^12.2 Young ET et al. (2002) Snf1 protein kinase regulates Adr1 binding to chromatin but not transcription activation. J Biol Chem 277: 38095-103 PubMed GONUTS page

[PMID:12024013-12] 13.0 ^13.1 ^13.2 Kuchin S et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22: 3994-4000 PubMed GONUTS page

[PMID:10322167-13] Carlson M (1999) Glucose repression in yeast. Curr Opin Microbiol 2: 202-7 PubMed GONUTS page

[PMID:18955495-14] 15.0 ^15.1 Shirra MK et al. (2008) A chemical genomics study identifies Snf1 as a repressor of GCN4 translation. J Biol Chem 283: 35889-98 PubMed GONUTS page

[PMID:2481228-15] 16.0 ^16.1 Celenza JL et al. (1989) Molecular analysis of the SNF4 gene of Saccharomyces cerevisiae: evidence for physical association of the SNF4 protein with the SNF1 protein kinase. Mol Cell Biol 9: 5045-54 PubMed GONUTS page

[PMID:9121458-16] Jiang R & Carlson M (1997) The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex. Mol Cell Biol 17: 2099-106 PubMed GONUTS page

[PMID:12393914-17] Nath N et al. (2002) Purification and characterization of Snf1 kinase complexes containing a defined Beta subunit composition. J Biol Chem 277: 50403-8 PubMed GONUTS page

[PMID:8628258-18] Lesage P et al. (1996) Yeast SNF1 protein kinase interacts with SIP4, a C6 zinc cluster transcriptional activator: a new role for SNF1 in the glucose response. Mol Cell Biol 16: 1921-8 PubMed GONUTS page

[PMID:9111319-19] Randez-Gil F et al. (1997) Glucose derepression of gluconeogenic enzymes in Saccharomyces cerevisiae correlates with phosphorylation of the gene activator Cat8p. Mol Cell Biol 17: 2502-10 PubMed GONUTS page

[PMID:8710504-20] Rahner A et al. (1996) Dual influence of the yeast Cat1p (Snf1p) protein kinase on carbon source-dependent transcriptional activation of gluconeogenic genes by the regulatory gene CAT8. Nucleic Acids Res 24: 2331-7 PubMed GONUTS page

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Species (Taxon ID)	Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s)	SNF1 ( synonyms: YDR477W, CAT1, CCR1, GLC2, HAF3, PAS14 )
Protein Name(s)	AMP-activated serine/threonine protein kinase,
External Links
SGD	S000002885

SGD:SNF1

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