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SGD:RVB2

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Contents

Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) RVB2 ( synonyms: YPL235W, TIH2, TIP48, TIP49B )
Protein Name(s) ATP-dependent DNA helicase, also known as reptin,
External Links
SGD S000006156

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

From SGD

GO:0000166

nucleotide binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From SGD

GO:0000492

box C/D snoRNP assembly

SGD_REF:S000066250
PMID:11604509[1]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0000492

box C/D snoRNP assembly

SGD_REF:S000136091
PMID:18268103[2]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0000812

Swr1 complex

SGD_REF:S000074662
PMID:14645854[3]

IPI: Inferred from Physical Interaction

SGD:S000002742

C

From SGD

GO:0000812

Swr1 complex

SGD_REF:S000075430
PMID:14690608[4]

IPI: Inferred from Physical Interaction

SGD:S000004505

C

From SGD

GO:0000812

Swr1 complex

SGD_REF:S000113597
PMID:16299513[5]

IDA: Inferred from Direct Assay

C

From SGD

GO:0003678

DNA helicase activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR010339

F

From SGD

GO:0004386

helicase activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0347

F

From SGD

GO:0005524

ATP binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR010339

F

From SGD

GO:0005524

ATP binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

From SGD

GO:0005634

nucleus

SGD_REF:S000066250
PMID:11604509[1]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005634

nucleus

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

From SGD

GO:0005654

nucleoplasm

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0190

C

From SGD

GO:0006281

DNA repair

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0234

P

From SGD

GO:0006338

chromatin remodeling

SGD_REF:S000075430
PMID:14690608[4]

IPI: Inferred from Physical Interaction

SGD:S000004505

P

From SGD

GO:0006351

transcription, DNA-dependent

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From SGD

GO:0006355

regulation of transcription, DNA-dependent

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

From SGD

GO:0006357

regulation of transcription from RNA polymerase II promoter

SGD_REF:S000060643
PMID:11278922[6]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006364

rRNA processing

SGD_REF:S000066250
PMID:11604509[1]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006364

rRNA processing

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0698

P

From SGD

GO:0006974

response to DNA damage stimulus

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0227

P

From SGD

GO:0016568

chromatin modification

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0156

P

From SGD

GO:0016787

hydrolase activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

From SGD

GO:0017111

nucleoside-triphosphatase activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

From SGD

GO:0031011

Ino80 complex

SGD_REF:S000040657
PMID:10952318[7]

IPI: Inferred from Physical Interaction

SGD:S000003118

C

From SGD

GO:0032508

DNA duplex unwinding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR010339

P

From SGD

GO:0043140

ATP-dependent 3'-5' DNA helicase activity

SGD_REF:S000134452
PMID:20553504[8]

IDA: Inferred from Direct Assay

F

From SGD

GO:0043141

ATP-dependent 5'-3' DNA helicase activity

SGD_REF:S000125377
PMID:18234224[9]

IDA: Inferred from Direct Assay

F

From SGD

GO:0043486

histone exchange

SGD_REF:S000074662
PMID:14645854[3]

IPI: Inferred from Physical Interaction

SGD:S000002742

P

From SGD

GO:0070209

ASTRA complex

SGD_REF:S000128493
PMID:19040720[10]

IDA: Inferred from Direct Assay

C

From SGD

GO:0097255

R2TP complex

SGD_REF:S000081009
PMID:15766533[11]

IDA: Inferred from Direct Assay

C

From SGD

GO:0097255

R2TP complex

SGD_REF:S000136091
PMID:18268103[2]

IPI: Inferred from Physical Interaction

SGD:S000002598
SGD:S000001076

C

From SGD

colocalizes_with

GO:0005724

nuclear telomeric heterochromatin

SGD_REF:S000147574
PMID:22100294[12]

IDA: Inferred from Direct Assay

C

From SGD

contributes_to

GO:0043140

ATP-dependent 3'-5' DNA helicase activity

SGD_REF:S000040657
PMID:10952318[7]

IDA: Inferred from Direct Assay

F

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 King TH et al. (2001) A well-connected and conserved nucleoplasmic helicase is required for production of box C/D and H/ACA snoRNAs and localization of snoRNP proteins. Mol Cell Biol 21: 7731-46 PubMed GONUTS page
  2. 2.0 2.1 Zhao R et al. (2008) Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation. J Cell Biol 180: 563-78 PubMed GONUTS page
  3. 3.0 3.1 Mizuguchi G et al. (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303: 343-8 PubMed GONUTS page
  4. 4.0 4.1 Krogan NJ et al. (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12: 1565-76 PubMed GONUTS page
  5. Wu WH et al. (2005) Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nat Struct Mol Biol 12: 1064-71 PubMed GONUTS page
  6. Jónsson ZO et al. (2001) Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes. J Biol Chem 276: 16279-88 PubMed GONUTS page
  7. 7.0 7.1 Shen X et al. (2000) A chromatin remodelling complex involved in transcription and DNA processing. Nature 406: 541-4 PubMed GONUTS page
  8. Papin C et al. (2010) 3'- to 5' DNA unwinding by TIP49b proteins. FEBS J 277: 2705-14 PubMed GONUTS page
  9. Gribun A et al. (2008) Yeast Rvb1 and Rvb2 are ATP-dependent DNA helicases that form a heterohexameric complex. J Mol Biol 376: 1320-33 PubMed GONUTS page
  10. Shevchenko A et al. (2008) Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment. Genome Biol 9: R167 PubMed GONUTS page
  11. Zhao R et al. (2005) Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell 120: 715-27 PubMed GONUTS page
  12. Grandin N & Charbonneau M (2011) Rvb2/reptin physically associates with telomerase in budding yeast. FEBS Lett 585: 3890-7 PubMed GONUTS page
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