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SGD:RAD3
Contents |
| Species (Taxon ID) | Saccharomyces cerevisiae (baker's yeast) (taxon:4932) | |
| Gene Name(s) | RAD3 ( synonyms: YER171W, REM1 ) | |
| Protein Name(s) | 5' to 3' DNA helicase, | |
| External Links | ||
| SGD | S000000973 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000019 |
regulation of mitotic recombination |
SGD_REF:S000050371 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0000019 |
regulation of mitotic recombination |
SGD_REF:S000051731 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0000112 |
nucleotide-excision repair factor 3 complex |
SGD_REF:S000044877 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0000166 |
nucleotide binding |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From SGD |
||
| GO:0000439 |
core TFIIH complex |
SGD_REF:S000075290 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0000439 |
core TFIIH complex |
SGD_REF:S000131946 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0003676 |
nucleic acid binding |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0003677 |
DNA binding |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0003677 |
DNA binding |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From SGD |
||
| GO:0003684 |
damaged DNA binding |
SGD_REF:S000048512 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0004003 |
ATP-dependent DNA helicase activity |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0004386 |
helicase activity |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0347 |
F |
From SGD |
||
| GO:0005524 |
ATP binding |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR006555 |
F |
From SGD |
||
| GO:0005524 |
ATP binding |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From SGD |
||
| GO:0005634 |
nucleus |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
C |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0539 |
C |
From SGD |
||
| GO:0005634 |
nucleus |
SGD_REF:S000148671 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0191 |
C |
From SGD |
||
| GO:0005675 |
holo TFIIH complex |
SGD_REF:S000131946 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0006139 |
nucleobase-containing compound metabolic process |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0006281 |
DNA repair |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0234 |
P |
From SGD |
||
| GO:0006289 |
nucleotide-excision repair |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0006351 |
transcription, DNA-dependent |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From SGD |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From SGD |
||
| GO:0006366 |
transcription from RNA polymerase II promoter |
SGD_REF:S000131946 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0006974 |
response to DNA damage stimulus |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0227 |
P |
From SGD |
||
| GO:0008026 |
ATP-dependent helicase activity |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0010525 |
regulation of transposition, RNA-mediated |
SGD_REF:S000051731 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0016787 |
hydrolase activity |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From SGD |
||
| GO:0016817 |
hydrolase activity, acting on acid anhydrides |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0016818 |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0033683 |
nucleotide-excision repair, DNA incision |
SGD_REF:S000063827 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0043141 |
ATP-dependent 5'-3' DNA helicase activity |
SGD_REF:S000040433 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0046872 |
metal ion binding |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From SGD |
||
| GO:0051536 |
iron-sulfur cluster binding |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0411 |
F |
From SGD |
||
| GO:0070816 |
phosphorylation of RNA polymerase II C-terminal domain |
SGD_REF:S000131207 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0070816 |
phosphorylation of RNA polymerase II C-terminal domain |
SGD_REF:S000133098 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
|
contributes_to |
GO:0000990 |
core RNA polymerase binding transcription factor activity |
SGD_REF:S000131946 |
IC: Inferred by Curator |
GO:0005675 |
F |
From SGD |
|
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Maines S et al. (1998) Novel mutations in the RAD3 and SSL1 genes perturb genome stability by stimulating recombination between short repeats in Saccharomyces cerevisiae. Genetics 150: 963-76 PubMed GONUTS page
- ↑ 2.0 2.1 Lee BS et al. (2000) Nucleotide excision repair/TFIIH helicases RAD3 and SSL2 inhibit short-sequence recombination and Ty1 retrotransposition by similar mechanisms. Mol Cell Biol 20: 2436-45 PubMed GONUTS page
- ↑ Habraken Y et al. (1996) Transcription factor TFIIH and DNA endonuclease Rad2 constitute yeast nucleotide excision repair factor 3: implications for nucleotide excision repair and Cockayne syndrome. Proc Natl Acad Sci U S A 93: 10718-22 PubMed GONUTS page
- ↑ Takagi Y et al. (2003) Revised subunit structure of yeast transcription factor IIH (TFIIH) and reconciliation with human TFIIH. J Biol Chem 278: 43897-900 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Yang C et al. (2010) Improved methods for expression and purification of Saccharomyces cerevisiae TFIIF and TFIIH; identification of a functional Escherichia coli promoter and internal translation initiation within the N-terminal coding region of the TFIIF TFG1 subunit. Protein Expr Purif 70: 172-8 PubMed GONUTS page
- ↑ Sung P et al. (1994) Negative superhelicity promotes ATP-dependent binding of yeast RAD3 protein to ultraviolet-damaged DNA. J Biol Chem 269: 8303-8 PubMed GONUTS page
- ↑ Sung P et al. (1996) Reconstitution of TFIIH and requirement of its DNA helicase subunits, Rad3 and Rad25, in the incision step of nucleotide excision repair. J Biol Chem 271: 10821-6 PubMed GONUTS page
- ↑ Sung P et al. (1987) RAD3 protein of Saccharomyces cerevisiae is a DNA helicase. Proc Natl Acad Sci U S A 84: 8951-5 PubMed GONUTS page
- ↑ Kim M et al. (2009) Phosphorylation of the yeast Rpb1 C-terminal domain at serines 2, 5, and 7. J Biol Chem 284: 26421-6 PubMed GONUTS page
- ↑ Akhtar MS et al. (2009) TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II. Mol Cell 34: 387-93 PubMed GONUTS page
