GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
SGD:RAD27
Contents |
| Species (Taxon ID) | Saccharomyces cerevisiae (baker's yeast) (taxon:4932) | |
| Gene Name(s) | RAD27 ( synonyms: YKL113C, ERC11, FEN1, RTH1 ) | |
| Protein Name(s) | 5' to 3' exonuclease, | |
| External Links | ||
| SGD | S000001596 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000734 |
gene conversion at mating-type locus, DNA repair synthesis |
SGD_REF:S000056091 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0001302 |
replicative cell aging |
SGD_REF:S000074686 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0003677 |
DNA binding |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0003824 |
catalytic activity |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0004518 |
nuclease activity |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0004518 |
nuclease activity |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0540 |
F |
From SGD |
||
| GO:0004519 |
endonuclease activity |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0255 |
F |
From SGD |
||
| GO:0004527 |
exonuclease activity |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0269 |
F |
From SGD |
||
| GO:0005634 |
nucleus |
SGD_REF:S000074185 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000131324 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0539 |
C |
From SGD |
||
| GO:0005654 |
nucleoplasm |
SGD_REF:S000148671 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0190 |
C |
From SGD |
||
| GO:0005730 |
nucleolus |
SGD_REF:S000148671 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0188 |
C |
From SGD |
||
| GO:0005739 |
mitochondrion |
SGD_REF:S000131324 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005739 |
mitochondrion |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0496 |
C |
From SGD |
||
| GO:0005739 |
mitochondrion |
SGD_REF:S000148671 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0173 |
C |
From SGD |
||
| GO:0006260 |
DNA replication |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0235 |
P |
From SGD |
||
| GO:0006281 |
DNA repair |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0006281 |
DNA repair |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0234 |
P |
From SGD |
||
| GO:0006286 |
base-excision repair, base-free sugar-phosphate removal |
SGD_REF:S000054983 |
IGI: Inferred from Genetic Interaction |
SGD:S000001597 |
P |
From SGD |
||
| GO:0006286 |
base-excision repair, base-free sugar-phosphate removal |
SGD_REF:S000054983 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0006303 |
double-strand break repair via nonhomologous end joining |
SGD_REF:S000079665 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0006974 |
response to DNA damage stimulus |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0227 |
P |
From SGD |
||
| GO:0008409 |
5'-3' exonuclease activity |
SGD_REF:S000039960 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0016787 |
hydrolase activity |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From SGD |
||
| GO:0016788 |
hydrolase activity, acting on ester bonds |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0017108 |
5'-flap endonuclease activity |
SGD_REF:S000069591 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0043137 |
DNA replication, removal of RNA primer |
SGD_REF:S000117063 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0046872 |
metal ion binding |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From SGD |
||
| GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Holmes AM & Haber JE (1999) Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases. Cell 96: 415-24 PubMed GONUTS page
- ↑ Hoopes LL et al. (2002) Mutations in DNA replication genes reduce yeast life span. Mol Cell Biol 22: 4136-46 PubMed GONUTS page
- ↑ Huh WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425: 686-91 PubMed GONUTS page
- ↑ 4.0 4.1 Kalifa L et al. (2009) Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity. DNA Repair (Amst) 8: 1242-9 PubMed GONUTS page
- ↑ 5.0 5.1 Wu X & Wang Z (1999) Relationships between yeast Rad27 and Apn1 in response to apurinic/apyrimidinic (AP) sites in DNA. Nucleic Acids Res 27: 956-62 PubMed GONUTS page
- ↑ Tseng HM & Tomkinson AE (2004) Processing and joining of DNA ends coordinated by interactions among Dnl4/Lif1, Pol4, and FEN-1. J Biol Chem 279: 47580-8 PubMed GONUTS page
- ↑ Zhu FX et al. (1997) Purification and characterization of the DNA polymerase alpha associated exonuclease: the RTH1 gene product. Biochemistry 36: 5947-54 PubMed GONUTS page
- ↑ Kao HI et al. (2002) Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate. J Biol Chem 277: 14379-89 PubMed GONUTS page
- ↑ Rossi ML & Bambara RA (2006) Reconstituted Okazaki fragment processing indicates two pathways of primer removal. J Biol Chem 281: 26051-61 PubMed GONUTS page
