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SGD:RAD2

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Contents

Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) RAD2 ( synonyms: YGR258C )
Protein Name(s) Single-stranded DNA endonuclease,
External Links
SGD S000003490

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000014

single-stranded DNA specific endodeoxyribonuclease activity

SGD_REF:S000045977
PMID:8247134[1]

IDA: Inferred from Direct Assay

F

From SGD

GO:0000112

nucleotide-excision repair factor 3 complex

SGD_REF:S000044877
PMID:8855246[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0003677

DNA binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR008918
InterPro:IPR020045

F

From SGD

GO:0003697

single-stranded DNA binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR001044

F

From SGD

GO:0003824

catalytic activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR008918
InterPro:IPR020045

F

From SGD

GO:0004518

nuclease activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR006084
InterPro:IPR006086
InterPro:IPR006085

F

From SGD

GO:0004518

nuclease activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0540

F

From SGD

GO:0004519

endonuclease activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR001044

F

From SGD

GO:0004519

endonuclease activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0255

F

From SGD

GO:0005634

nucleus

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR001044

C

From SGD

GO:0005634

nucleus

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

From SGD

GO:0005634

nucleus

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

From SGD

GO:0006281

DNA repair

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR006084
InterPro:IPR006086
InterPro:IPR006085

P

From SGD

GO:0006281

DNA repair

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0234

P

From SGD

GO:0006289

nucleotide-excision repair

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR001044

P

From SGD

GO:0006295

nucleotide-excision repair, DNA incision, 3'-to lesion

SGD_REF:S000054237
PMID:7926735[3]

IDA: Inferred from Direct Assay

P

From SGD

GO:0006295

nucleotide-excision repair, DNA incision, 3'-to lesion

SGD_REF:S000054237
PMID:7926735[3]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006366

transcription from RNA polymerase II promoter

SGD_REF:S000070302
PMID:12110180[4]

IGI: Inferred from Genetic Interaction

SGD:S000003796
SGD:S000003011

P

From SGD

GO:0006974

response to DNA damage stimulus

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0227

P

From SGD

GO:0016787

hydrolase activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

From SGD

GO:0016788

hydrolase activity, acting on ester bonds

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR019974

F

From SGD

GO:0046872

metal ion binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From SGD

GO:0090305

nucleic acid phosphodiester bond hydrolysis

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR006084
InterPro:IPR006086
InterPro:IPR006085

P

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Habraken Y et al. (1993) Yeast excision repair gene RAD2 encodes a single-stranded DNA endonuclease. Nature 366: 365-8 PubMed GONUTS page
  2. Habraken Y et al. (1996) Transcription factor TFIIH and DNA endonuclease Rad2 constitute yeast nucleotide excision repair factor 3: implications for nucleotide excision repair and Cockayne syndrome. Proc Natl Acad Sci U S A 93: 10718-22 PubMed GONUTS page
  3. 3.0 3.1 Harrington JJ & Lieber MR (1994) Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair. Genes Dev 8: 1344-55 PubMed GONUTS page
  4. Lee SK et al. (2002) Requirement of yeast RAD2, a homolog of human XPG gene, for efficient RNA polymerase II transcription. implications for Cockayne syndrome. Cell 109: 823-34 PubMed GONUTS page
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