GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
SGD:NHX1
Contents |
| Species (Taxon ID) | Saccharomyces cerevisiae (baker's yeast) (taxon:4932) | |
| Gene Name(s) | NHX1 ( synonyms: YDR456W, NHA2, VPL27, VPS44 ) | |
| Protein Name(s) | Na+/H+ and K+/H+ exchanger, | |
| External Links | ||
| SGD | S000002864 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000329 |
fungal-type vacuole membrane |
SGD_REF:S000136282 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005768 |
endosome |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0967 |
C |
From SGD |
||
| GO:0005769 |
early endosome |
SGD_REF:S000148056 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005770 |
late endosome |
SGD_REF:S000039966 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005770 |
late endosome |
SGD_REF:S000135694 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005770 |
late endosome |
SGD_REF:S000148056 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005802 |
trans-Golgi network |
SGD_REF:S000148056 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0006810 |
transport |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0813 |
P |
From SGD |
||
| GO:0006811 |
ion transport |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0406 |
P |
From SGD |
||
| GO:0006812 |
cation transport |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0006813 |
potassium ion transport |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0633 |
P |
From SGD |
||
| GO:0006814 |
sodium ion transport |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0006814 |
sodium ion transport |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0739 |
P |
From SGD |
||
| GO:0006885 |
regulation of pH |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0007035 |
vacuolar acidification |
SGD_REF:S000042739 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0010008 |
endosome membrane |
SGD_REF:S000148671 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0100 |
C |
From SGD |
||
| GO:0015297 |
antiporter activity |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0050 |
F |
From SGD |
||
| GO:0015299 |
solute:hydrogen antiporter activity |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0015385 |
sodium:hydrogen antiporter activity |
SGD_REF:S000046741 |
IMP: Inferred from Mutant Phenotype |
F |
From SGD |
|||
| GO:0015385 |
sodium:hydrogen antiporter activity |
SGD_REF:S000080349 |
IMP: Inferred from Mutant Phenotype |
F |
From SGD |
|||
| GO:0015385 |
sodium:hydrogen antiporter activity |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0015386 |
potassium:hydrogen antiporter activity |
SGD_REF:S000080349 |
IMP: Inferred from Mutant Phenotype |
F |
From SGD |
|||
| GO:0016020 |
membrane |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From SGD |
||
| GO:0016021 |
integral to membrane |
SGD_REF:S000114049 |
ISM: Inferred from Sequence Model |
C |
From SGD |
|||
| GO:0016021 |
integral to membrane |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
C |
From SGD |
|||
| GO:0016021 |
integral to membrane |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From SGD |
||
| GO:0030004 |
cellular monovalent inorganic cation homeostasis |
SGD_REF:S000042739 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0031902 |
late endosome membrane |
SGD_REF:S000148671 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0224 |
C |
From SGD |
||
| GO:0035725 |
sodium ion transmembrane transport |
SGD_REF:S000046741 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0035725 |
sodium ion transmembrane transport |
SGD_REF:S000080349 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0055085 |
transmembrane transport |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0071805 |
potassium ion transmembrane transport |
SGD_REF:S000080349 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Qiu QS & Fratti RA (2010) The Na+/H+ exchanger Nhx1p regulates the initiation of Saccharomyces cerevisiae vacuole fusion. J Cell Sci 123: 3266-75 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Kojima A et al. (2012) Localization and functional requirement of yeast Na+/H+ exchanger, Nhx1p, in the endocytic and protein recycling pathway. Biochim Biophys Acta 1823: 534-43 PubMed GONUTS page
- ↑ Nass R & Rao R (1998) Novel localization of a Na+/H+ exchanger in a late endosomal compartment of yeast. Implications for vacuole biogenesis. J Biol Chem 273: 21054-60 PubMed GONUTS page
- ↑ Cagnac O et al. (2010) Vacuolar cation/H+ antiporters of Saccharomyces cerevisiae. J Biol Chem 285: 33914-22 PubMed GONUTS page
- ↑ 5.0 5.1 Nass R & Rao R (1999) The yeast endosomal Na+/H+ exchanger, Nhx1, confers osmotolerance following acute hypertonic shock. Microbiology 145 ( Pt 11): 3221-8 PubMed GONUTS page
- ↑ 6.0 6.1 Darley CP et al. (2000) Arabidopsis thaliana and Saccharomyces cerevisiae NHX1 genes encode amiloride sensitive electroneutral Na+/H+ exchangers. Biochem J 351: 241-9 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Brett CL et al. (2005) The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle trafficking. Mol Biol Cell 16: 1396-405 PubMed GONUTS page
- ↑ De Hertogh B et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2: 154-70 PubMed GONUTS page
