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SGD:NHP6B

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Contents

Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) NHP6B ( synonyms: YBR089C-A, YBR090C-A )
Protein Name(s) High-mobility group protein that binds to and remodels nucleosomes,
External Links
SGD S000002157

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

From SGD

GO:0005634

nucleus

SGD_REF:S000057037
PMID:3169249[1]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005634

nucleus

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

From SGD

GO:0005634

nucleus

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

From SGD

GO:0005694

chromosome

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0158

C

From SGD

GO:0005694

chromosome

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0468

C

From SGD

GO:0006281

DNA repair

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0234

P

From SGD

GO:0006338

chromatin remodeling

SGD_REF:S000076895
PMID:14739928[2]

IGI: Inferred from Genetic Interaction

SGD:S000006256
SGD:S000000316

P

From SGD

GO:0006351

transcription, DNA-dependent

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From SGD

GO:0006355

regulation of transcription, DNA-dependent

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

From SGD

GO:0006366

transcription from RNA polymerase II promoter

SGD_REF:S000052961
PMID:8946917[3]

IGI: Inferred from Genetic Interaction

SGD:S000006256

P

From SGD

GO:0006974

response to DNA damage stimulus

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0227

P

From SGD

GO:0008301

DNA binding, bending

SGD_REF:S000052281
PMID:7721780[4]

IDA: Inferred from Direct Assay

F

From SGD

GO:0031491

nucleosome binding

SGD_REF:S000061420
PMID:11432837[5]

ISS: Inferred from Sequence or Structural Similarity

SGD:S000006256

F

From SGD

GO:0043565

sequence-specific DNA binding

SGD_REF:S000129025
PMID:19158363[6]

IDA: Inferred from Direct Assay

F

From SGD

GO:0070898

RNA polymerase III transcriptional preinitiation complex assembly

SGD_REF:S000060366
PMID:11287614[7]

IGI: Inferred from Genetic Interaction

SGD:S000006256
SGD:S000006494

P

From SGD

GO:0070898

RNA polymerase III transcriptional preinitiation complex assembly

SGD_REF:S000120089
PMID:17178828[8]

IDA: Inferred from Direct Assay

P

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Kolodrubetz D et al. (1988) Amino-terminal sequence of a Saccharomyces cerevisiae nuclear protein, NHP6, shows significant identity to bovine HMG1. FEBS Lett 238: 175-9 PubMed GONUTS page
  2. Fragiadakis GS et al. (2004) Nhp6 facilitates Aft1 binding and Ssn6 recruitment, both essential for FRE2 transcriptional activation. EMBO J 23: 333-42 PubMed GONUTS page
  3. Paull TT et al. (1996) Yeast HMG proteins NHP6A/B potentiate promoter-specific transcriptional activation in vivo and assembly of preinitiation complexes in vitro. Genes Dev 10: 2769-81 PubMed GONUTS page
  4. Paull TT & Johnson RC (1995) DNA looping by Saccharomyces cerevisiae high mobility group proteins NHP6A/B. Consequences for nucleoprotein complex assembly and chromatin condensation. J Biol Chem 270: 8744-54 PubMed GONUTS page
  5. Formosa T et al. (2001) Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN. EMBO J 20: 3506-17 PubMed GONUTS page
  6. Zhu C et al. (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19: 556-66 PubMed GONUTS page
  7. Lopez S et al. (2001) High-mobility-group proteins NHP6A and NHP6B participate in activation of the RNA polymerase III SNR6 gene. Mol Cell Biol 21: 3096-104 PubMed GONUTS page
  8. Braglia P et al. (2007) Requirement of Nhp6 proteins for transcription of a subset of tRNA genes and heterochromatin barrier function in Saccharomyces cerevisiae. Mol Cell Biol 27: 1545-57 PubMed GONUTS page
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