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SGD:NHA1

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Contents

Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) NHA1 ( synonyms: YLR138W )
Protein Name(s) Na+/H+ antiporter involved in sodium and potassium efflux,
External Links
SGD S000004128

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005886

plasma membrane

SGD_REF:S000047735
PMID:9802016[1]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005886

plasma membrane

SGD_REF:S000082239
PMID:15950597[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0006810

transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

From SGD

GO:0006811

ion transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0406

P

From SGD

GO:0006812

cation transport

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR006153

P

From SGD

GO:0006814

sodium ion transport

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR013928
InterPro:IPR004712

P

From SGD

GO:0006814

sodium ion transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0739

P

From SGD

GO:0006970

response to osmotic stress

SGD_REF:S000114072
PMID:16402204[3]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0015297

antiporter activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0050

F

From SGD

GO:0015299

solute:hydrogen antiporter activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR006153

F

From SGD

GO:0015385

sodium:hydrogen antiporter activity

SGD_REF:S000082239
PMID:15950597[2]

IDA: Inferred from Direct Assay

F

From SGD

GO:0015385

sodium:hydrogen antiporter activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR013928
InterPro:IPR004712

F

From SGD

GO:0015491

cation:cation antiporter activity

SGD_REF:S000047735
PMID:9802016[1]

IMP: Inferred from Mutant Phenotype

F

From SGD

GO:0015491

cation:cation antiporter activity

SGD_REF:S000051446
PMID:8654575[4]

ISS: Inferred from Sequence or Structural Similarity

F

From SGD

GO:0016020

membrane

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR013928

C

From SGD

GO:0016020

membrane

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From SGD

GO:0016020

membrane

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

From SGD

GO:0016021

integral to membrane

SGD_REF:S000114049
PMID:12192589[5]

ISM: Inferred from Sequence Model

C

From SGD

GO:0016021

integral to membrane

SGD_REF:S000120078
PMID:17176761[6]

ISM: Inferred from Sequence Model

C

From SGD

GO:0016021

integral to membrane

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR004712
InterPro:IPR006153

C

From SGD

GO:0016021

integral to membrane

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From SGD

GO:0030004

cellular monovalent inorganic cation homeostasis

SGD_REF:S000047735
PMID:9802016[1]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0030007

cellular potassium ion homeostasis

SGD_REF:S000114072
PMID:16402204[3]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0045121

membrane raft

SGD_REF:S000129503
PMID:19254924[7]

IDA: Inferred from Direct Assay

C

From SGD

GO:0055085

transmembrane transport

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR006153

P

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Bañuelos MA et al. (1998) The Nha1 antiporter of Saccharomyces cerevisiae mediates sodium and potassium efflux. Microbiology 144 ( Pt 10): 2749-58 PubMed GONUTS page
  2. 2.0 2.1 Ohgaki R et al. (2005) Characterization of the ion transport activity of the budding yeast Na+/H+ antiporter, Nha1p, using isolated secretory vesicles. Biochim Biophys Acta 1712: 185-96 PubMed GONUTS page
  3. 3.0 3.1 Kinclova-Zimmermannova O & Sychrova H (2006) Functional study of the Nha1p C-terminus: involvement in cell response to changes in external osmolarity. Curr Genet 49: 229-36 PubMed GONUTS page
  4. Prior C et al. (1996) Characterization of the NHA1 gene encoding a Na+/H+-antiporter of the yeast Saccharomyces cerevisiae. FEBS Lett 387: 89-93 PubMed GONUTS page
  5. De Hertogh B et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2: 154-70 PubMed GONUTS page
  6. Pribylová L et al. (2006) Exploration of yeast alkali metal cation/H+ antiporters: sequence and structure comparison. Folia Microbiol (Praha) 51: 413-24 PubMed GONUTS page
  7. Mitsui K et al. (2009) Saccharomyces cerevisiae Na+/H+ antiporter Nha1p associates with lipid rafts and requires sphingolipid for stable localization to the plasma membrane. J Biochem 145: 709-20 PubMed GONUTS page
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