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SGD:MRE11
Contents |
| Species (Taxon ID) | Saccharomyces cerevisiae (baker's yeast) (taxon:4932) | |
| Gene Name(s) | MRE11 ( synonyms: YMR224C, NGS1, RAD58, XRS4 ) | |
| Protein Name(s) | Subunit of a complex with Rad50p and Xrs2p (MRX complex), | |
| External Links | ||
| SGD | S000004837 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000706 |
meiotic DNA double-strand break processing |
SGD_REF:S000069981 |
TAS: Traceable Author Statement |
P |
From SGD |
|||
| GO:0000727 |
double-strand break repair via break-induced replication |
SGD_REF:S000121266 |
IGI: Inferred from Genetic Interaction |
SGD:S000004897 |
P |
From SGD |
||
| GO:0000727 |
double-strand break repair via break-induced replication |
SGD_REF:S000121266 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0003691 |
double-stranded telomeric DNA binding |
SGD_REF:S000123824 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0004518 |
nuclease activity |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0540 |
F |
From SGD |
||
| GO:0004519 |
endonuclease activity |
SGD_REF:S000042701 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0004519 |
endonuclease activity |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0004519 |
endonuclease activity |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0255 |
F |
From SGD |
||
| GO:0004520 |
endodeoxyribonuclease activity |
SGD_REF:S000086451 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0004527 |
exonuclease activity |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0004527 |
exonuclease activity |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0269 |
F |
From SGD |
||
| GO:0005634 |
nucleus |
SGD_REF:S000050527 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000082253 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
C |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0539 |
C |
From SGD |
||
| GO:0005634 |
nucleus |
SGD_REF:S000148671 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0191 |
C |
From SGD |
||
| GO:0005739 |
mitochondrion |
SGD_REF:S000075100 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005739 |
mitochondrion |
SGD_REF:S000117178 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0006259 |
DNA metabolic process |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0006281 |
DNA repair |
SGD_REF:S000050826 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0006281 |
DNA repair |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0234 |
P |
From SGD |
||
| GO:0006284 |
base-excision repair |
SGD_REF:S000132576 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0006302 |
double-strand break repair |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0006303 |
double-strand break repair via nonhomologous end joining |
SGD_REF:S000073203 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0006974 |
response to DNA damage stimulus |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0227 |
P |
From SGD |
||
| GO:0007126 |
meiosis |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0469 |
P |
From SGD |
||
| GO:0008408 |
3'-5' exonuclease activity |
SGD_REF:S000065930 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0016787 |
hydrolase activity |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0016787 |
hydrolase activity |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From SGD |
||
| GO:0030145 |
manganese ion binding |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0030437 |
ascospore formation |
SGD_REF:S000122029 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0030870 |
Mre11 complex |
SGD_REF:S000050527 |
IPI: Inferred from Physical Interaction |
C |
From SGD |
|||
| GO:0032947 |
protein complex scaffold |
SGD_REF:S000050527 |
IGI: Inferred from Genetic Interaction |
SGD:S000002777 |
F |
From SGD |
||
| GO:0032947 |
protein complex scaffold |
SGD_REF:S000050527 |
IMP: Inferred from Mutant Phenotype |
F |
From SGD |
|||
| GO:0042138 |
meiotic DNA double-strand break formation |
SGD_REF:S000069981 |
TAS: Traceable Author Statement |
P |
From SGD |
|||
| GO:0042162 |
telomeric DNA binding |
SGD_REF:S000080865 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0042162 |
telomeric DNA binding |
SGD_REF:S000086451 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0043047 |
single-stranded telomeric DNA binding |
SGD_REF:S000123824 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0051037 |
regulation of transcription during meiosis |
SGD_REF:S000122029 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0051880 |
G-quadruplex DNA binding |
SGD_REF:S000123824 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
|
contributes_to |
GO:0004017 |
adenylate kinase activity |
SGD_REF:S000121365 |
IDA: Inferred from Direct Assay |
F |
From SGD |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Roeder GS (1997) Meiotic chromosomes: it takes two to tango. Genes Dev 11: 2600-21 PubMed GONUTS page
- ↑ 2.0 2.1 Krishna S et al. (2007) Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication. DNA Repair (Amst) 6: 797-808 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Ghosal G & Muniyappa K (2007) The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity. J Mol Biol 372: 864-82 PubMed GONUTS page
- ↑ Moreau S et al. (1999) The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol Cell Biol 19: 556-66 PubMed GONUTS page
- ↑ 5.0 5.1 Ghosal G & Muniyappa K (2005) Saccharomyces cerevisiae Mre11 is a high-affinity G4 DNA-binding protein and a G-rich DNA-specific endonuclease: implications for replication of telomeric DNA. Nucleic Acids Res 33: 4692-703 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Usui T et al. (1998) Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 95: 705-16 PubMed GONUTS page
- ↑ Tsukamoto Y et al. (2005) Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination. Mol Biol Cell 16: 597-608 PubMed GONUTS page
- ↑ Sickmann A et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100: 13207-12 PubMed GONUTS page
- ↑ Reinders J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5: 1543-54 PubMed GONUTS page
- ↑ Johzuka K & Ogawa H (1995) Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae. Genetics 139: 1521-32 PubMed GONUTS page
- ↑ Steininger S et al. (2010) A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair. Nucleic Acids Res 38: 1853-65 PubMed GONUTS page
- ↑ Wilson TE (2002) A genomics-based screen for yeast mutants with an altered recombination/end-joining repair ratio. Genetics 162: 677-88 PubMed GONUTS page
- ↑ Trujillo KM & Sung P (2001) DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex. J Biol Chem 276: 35458-64 PubMed GONUTS page
- ↑ 14.0 14.1 Kugou K et al. (2007) Mre11 mediates gene regulation in yeast spore development. Genes Genet Syst 82: 21-33 PubMed GONUTS page
- ↑ Takata H et al. (2005) Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae. Mol Cell 17: 573-83 PubMed GONUTS page
- ↑ Bhaskara V et al. (2007) Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes. Mol Cell 25: 647-61 PubMed GONUTS page
