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SGD:MRC1
Contents |
| Species (Taxon ID) | Saccharomyces cerevisiae (baker's yeast) (taxon:4932) | |
| Gene Name(s) | MRC1 ( synonyms: YCL061C, YCL060C ) | |
| Protein Name(s) | S-phase checkpoint protein required for DNA replication, | |
| External Links | ||
| SGD | S000000566 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000076 |
DNA replication checkpoint |
SGD_REF:S000061242 |
IGI: Inferred from Genetic Interaction |
P |
From SGD |
|||
| GO:0000076 |
DNA replication checkpoint |
SGD_REF:S000061242 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0000076 |
DNA replication checkpoint |
SGD_REF:S000068879 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0000076 |
DNA replication checkpoint |
SGD_REF:S000073860 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0000076 |
DNA replication checkpoint |
SGD_REF:S000073860 |
IPI: Inferred from Physical Interaction |
P |
From SGD |
|||
| GO:0000228 |
nuclear chromosome |
SGD_REF:S000073860 |
IPI: Inferred from Physical Interaction |
C |
From SGD |
|||
| GO:0000723 |
telomere maintenance |
SGD_REF:S000121145 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0003674 |
molecular function |
SGD_REF:S000069584 |
ND: No biological Data available |
F |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000074185 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0539 |
C |
From SGD |
||
| GO:0005634 |
nucleus |
SGD_REF:S000148671 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0191 |
C |
From SGD |
||
| GO:0006260 |
DNA replication |
SGD_REF:S000086564 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0006260 |
DNA replication |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0235 |
P |
From SGD |
||
| GO:0006281 |
DNA repair |
SGD_REF:S000086856 |
IGI: Inferred from Genetic Interaction |
SGD:S000002625 |
P |
From SGD |
||
| GO:0006281 |
DNA repair |
SGD_REF:S000086856 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0006348 |
chromatin silencing at telomere |
SGD_REF:S000061242 |
IGI: Inferred from Genetic Interaction |
P |
From SGD |
|||
| GO:0006348 |
chromatin silencing at telomere |
SGD_REF:S000061242 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0007064 |
mitotic sister chromatid cohesion |
SGD_REF:S000125415 |
IGI: Inferred from Genetic Interaction |
SGD:S000005929 |
P |
From SGD |
||
| GO:0007064 |
mitotic sister chromatid cohesion |
SGD_REF:S000125415 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0030466 |
chromatin silencing at silent mating-type cassette |
SGD_REF:S000061242 |
IGI: Inferred from Genetic Interaction |
P |
From SGD |
|||
| GO:0030466 |
chromatin silencing at silent mating-type cassette |
SGD_REF:S000061242 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0031298 |
replication fork protection complex |
SGD_REF:S000119454 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0031573 |
intra-S DNA damage checkpoint |
SGD_REF:S000068879 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0043570 |
maintenance of DNA repeat elements |
SGD_REF:S000125753 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0043596 |
nuclear replication fork |
SGD_REF:S000086399 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0048478 |
replication fork protection |
SGD_REF:S000127065 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0048478 |
replication fork protection |
SGD_REF:S000128058 |
IGI: Inferred from Genetic Interaction |
SGD:S000005206 |
P |
From SGD |
||
| GO:0048478 |
replication fork protection |
SGD_REF:S000128058 |
IPI: Inferred from Physical Interaction |
SGD:S000005206 |
P |
From SGD |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Hu F et al. (2001) Asf1 links Rad53 to control of chromatin assembly. Genes Dev 15: 1061-6 PubMed GONUTS page
- ↑ 2.0 2.1 Alcasabas AA et al. (2001) Mrc1 transduces signals of DNA replication stress to activate Rad53. Nat Cell Biol 3: 958-65 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Katou Y et al. (2003) S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424: 1078-83 PubMed GONUTS page
- ↑ Grandin N & Charbonneau M (2007) Mrc1, a non-essential DNA replication protein, is required for telomere end protection following loss of capping by Cdc13, Yku or telomerase. Mol Genet Genomics 277: 685-99 PubMed GONUTS page
- ↑ Huh WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425: 686-91 PubMed GONUTS page
- ↑ Tourrière H et al. (2005) Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53. Mol Cell 19: 699-706 PubMed GONUTS page
- ↑ 7.0 7.1 Redon C et al. (2006) Genetic analysis of Saccharomyces cerevisiae H2A serine 129 mutant suggests a functional relationship between H2A and the sister-chromatid cohesion partners Csm3-Tof1 for the repair of topoisomerase I-induced DNA damage. Genetics 172: 67-76 PubMed GONUTS page
- ↑ 8.0 8.1 Xu H et al. (2007) Genetic dissection of parallel sister-chromatid cohesion pathways. Genetics 176: 1417-29 PubMed GONUTS page
- ↑ Gambus A et al. (2006) GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol 8: 358-66 PubMed GONUTS page
- ↑ Razidlo DF & Lahue RS (2008) Mrc1, Tof1 and Csm3 inhibit CAG.CTG repeat instability by at least two mechanisms. DNA Repair (Amst) 7: 633-40 PubMed GONUTS page
- ↑ Calzada A et al. (2005) Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork. Genes Dev 19: 1905-19 PubMed GONUTS page
- ↑ Voineagu I et al. (2008) Replication stalling at unstable inverted repeats: interplay between DNA hairpins and fork stabilizing proteins. Proc Natl Acad Sci U S A 105: 9936-41 PubMed GONUTS page
- ↑ 13.0 13.1 Lou H et al. (2008) Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint. Mol Cell 32: 106-17 PubMed GONUTS page
