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SGD:MCM2
Contents |
| Species (Taxon ID) | Saccharomyces cerevisiae (baker's yeast) (taxon:4932) | |
| Gene Name(s) | MCM2 ( synonyms: YBL023C ) | |
| Protein Name(s) | Protein involved in DNA replication, | |
| External Links | ||
| SGD | S000000119 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000084 |
S phase of mitotic cell cycle |
SGD_REF:S000052255 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0000166 |
nucleotide binding |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From SGD |
||
| GO:0000727 |
double-strand break repair via break-induced replication |
SGD_REF:S000134596 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0003677 |
DNA binding |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0003677 |
DNA binding |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From SGD |
||
| GO:0003682 |
chromatin binding |
SGD_REF:S000040243 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0003688 |
DNA replication origin binding |
SGD_REF:S000069571 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0003688 |
DNA replication origin binding |
SGD_REF:S000117043 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0004386 |
helicase activity |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0347 |
F |
From SGD |
||
| GO:0005524 |
ATP binding |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0005524 |
ATP binding |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From SGD |
||
| GO:0005634 |
nucleus |
SGD_REF:S000051716 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
C |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0539 |
C |
From SGD |
||
| GO:0005634 |
nucleus |
SGD_REF:S000148671 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0191 |
C |
From SGD |
||
| GO:0005656 |
pre-replicative complex |
SGD_REF:S000054350 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005656 |
pre-replicative complex |
SGD_REF:S000117043 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005737 |
cytoplasm |
SGD_REF:S000051716 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0006260 |
DNA replication |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0006260 |
DNA replication |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0235 |
P |
From SGD |
||
| GO:0006267 |
pre-replicative complex assembly |
SGD_REF:S000054350 |
IPI: Inferred from Physical Interaction |
P |
From SGD |
|||
| GO:0006267 |
pre-replicative complex assembly |
SGD_REF:S000117043 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0006270 |
DNA-dependent DNA replication initiation |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0006271 |
DNA strand elongation involved in DNA replication |
SGD_REF:S000052255 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0007049 |
cell cycle |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0131 |
P |
From SGD |
||
| GO:0016787 |
hydrolase activity |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From SGD |
||
| GO:0031261 |
DNA replication preinitiation complex |
SGD_REF:S000055792 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0031298 |
replication fork protection complex |
SGD_REF:S000119454 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0042555 |
MCM complex |
SGD_REF:S000072578 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0046872 |
metal ion binding |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From SGD |
||
|
contributes_to |
GO:0003697 |
single-stranded DNA binding |
SGD_REF:S000124184 |
IMP: Inferred from Mutant Phenotype |
F |
From SGD |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Labib K et al. (2000) Uninterrupted MCM2-7 function required for DNA replication fork progression. Science 288: 1643-7 PubMed GONUTS page
- ↑ Lydeard JR et al. (2010) Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly. Genes Dev 24: 1133-44 PubMed GONUTS page
- ↑ Homesley L et al. (2000) Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins. Genes Dev 14: 913-26 PubMed GONUTS page
- ↑ Wilmes GM & Bell SP (2002) The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation. Proc Natl Acad Sci U S A 99: 101-6 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Kawasaki Y et al. (2006) Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro. Genes Cells 11: 745-56 PubMed GONUTS page
- ↑ 6.0 6.1 Nguyen VQ et al. (2000) Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7. Curr Biol 10: 195-205 PubMed GONUTS page
- ↑ 7.0 7.1 Aparicio OM et al. (1997) Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell 91: 59-69 PubMed GONUTS page
- ↑ Zou L & Stillman B (1998) Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin. Science 280: 593-6 PubMed GONUTS page
- ↑ Gambus A et al. (2006) GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol 8: 358-66 PubMed GONUTS page
- ↑ Davey MJ et al. (2003) Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture. J Biol Chem 278: 4491-9 PubMed GONUTS page
- ↑ Bochman ML & Schwacha A (2007) Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step. J Biol Chem 282: 33795-804 PubMed GONUTS page
