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SGD:LYS14

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Contents

Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) LYS14 ( synonyms: YDR034C )
Protein Name(s) Transcriptional activator involved in regulating lysine biosynthesis,
External Links
SGD S000002441

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000978

RNA polymerase II core promoter proximal region sequence-specific DNA binding

SGD_REF:S000045051
PMID:9701810[1]

IDA: Inferred from Direct Assay

F

From SGD

GO:0000981

sequence-specific DNA binding RNA polymerase II transcription factor activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR001138

F

From SGD

GO:0001077

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

SGD_REF:S000053639
PMID:7935367[2]

ISA: Inferred from Sequence Alignment

SGD:S000006169

F

From SGD

GO:0003677

DNA binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

From SGD

GO:0005634

nucleus

SGD_REF:S000059225
PMID:10975256[3]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005634

nucleus

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR001138

C

From SGD

GO:0005634

nucleus

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

From SGD

GO:0005634

nucleus

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

From SGD

GO:0006351

transcription, DNA-dependent

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From SGD

GO:0006355

regulation of transcription, DNA-dependent

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR001138

P

From SGD

GO:0006355

regulation of transcription, DNA-dependent

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

From SGD

GO:0006357

regulation of transcription from RNA polymerase II promoter

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR001138

P

From SGD

GO:0006366

transcription from RNA polymerase II promoter

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR001138

P

From SGD

GO:0008270

zinc ion binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR001138

F

From SGD

GO:0008652

cellular amino acid biosynthetic process

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0028

P

From SGD

GO:0009085

lysine biosynthetic process

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0457

P

From SGD

GO:0043565

sequence-specific DNA binding

SGD_REF:S000128778
PMID:19111667[4]

IDA: Inferred from Direct Assay

F

From SGD

GO:0043565

sequence-specific DNA binding

SGD_REF:S000129025
PMID:19158363[5]

IDA: Inferred from Direct Assay

F

From SGD

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

SGD_REF:S000053639
PMID:7935367[2]

IDA: Inferred from Direct Assay

P

From SGD

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

SGD_REF:S000055949
PMID:3123231[6]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

SGD_REF:S000069583
PMID:11952910[7]

IDA: Inferred from Direct Assay

P

From SGD

GO:0046872

metal ion binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From SGD

GO:2001196

positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine

SGD_REF:S000055949
PMID:3123231[6]

IMP: Inferred from Mutant Phenotype

P

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Becker B et al. (1998) A nonameric core sequence is required upstream of the LYS genes of Saccharomyces cerevisiae for Lys14p-mediated activation and apparent repression by lysine. Mol Microbiol 29: 151-63 PubMed GONUTS page
  2. 2.0 2.1 Feller A et al. (1994) Repression of the genes for lysine biosynthesis in Saccharomyces cerevisiae is caused by limitation of Lys14-dependent transcriptional activation. Mol Cell Biol 14: 6411-8 PubMed GONUTS page
  3. El Alami M et al. (2000) Characterisation of a tripartite nuclear localisation sequence in the regulatory protein Lys14 of Saccharomyces cerevisiae. Curr Genet 38: 78-86 PubMed GONUTS page
  4. Badis G et al. (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32: 878-87 PubMed GONUTS page
  5. Zhu C et al. (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19: 556-66 PubMed GONUTS page
  6. 6.0 6.1 Ramos F et al. (1988) Control of enzyme synthesis in the lysine biosynthetic pathway of Saccharomyces cerevisiae. Evidence for a regulatory role of gene LYS14. Eur J Biochem 171: 171-6 PubMed GONUTS page
  7. El Alami M et al. (2002) The proper folding of a long C-terminal segment of the yeast Lys14p regulator is required for activation of LYS genes in response to the metabolic effector. Mol Microbiol 43: 1629-39 PubMed GONUTS page
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