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SGD:KAP95

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Contents

Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) KAP95 ( synonyms: YLR347C, RSL1 )
Protein Name(s) Karyopherin beta,
External Links
SGD S000004339

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005087

Ran guanyl-nucleotide exchange factor activity

SGD_REF:S000130748
PMID:19549784[1]

IDA: Inferred from Direct Assay

F

From SGD

GO:0005634

nucleus

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

From SGD

GO:0005635

nuclear envelope

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0178

C

From SGD

GO:0005643

nuclear pore

SGD_REF:S000056415
PMID:10684247[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000056415
PMID:10684247[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

From SGD

GO:0006606

protein import into nucleus

SGD_REF:S000128919
PMID:19141610[3]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006612

protein targeting to membrane

SGD_REF:S000123937
PMID:16929305[4]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006656

phosphatidylcholine biosynthetic process

SGD_REF:S000128919
PMID:19141610[3]

IGI: Inferred from Genetic Interaction

SGD:S000003434

P

From SGD

GO:0006656

phosphatidylcholine biosynthetic process

SGD_REF:S000128919
PMID:19141610[3]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006810

transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

From SGD

GO:0006886

intracellular protein transport

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR001494

P

From SGD

GO:0008565

protein transporter activity

SGD_REF:S000046571
PMID:7622450[5]

IDA: Inferred from Direct Assay

F

From SGD

GO:0008565

protein transporter activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR001494

F

From SGD

GO:0015031

protein transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0653

P

From SGD

GO:0016021

integral to membrane

SGD_REF:S000114049
PMID:12192589[6]

ISM: Inferred from Sequence Model

C

From SGD

GO:0051292

nuclear pore complex assembly

SGD_REF:S000120075
PMID:17182855[7]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0060188

regulation of protein desumoylation

SGD_REF:S000122132
PMID:17403926[8]

IMP: Inferred from Mutant Phenotype

P

From SGD

colocalizes_with

GO:0000176

nuclear exosome (RNase complex)

SGD_REF:S000128567
PMID:19046973[9]

IDA: Inferred from Direct Assay

C

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Lonhienne TG et al. (2009) Importin-beta is a GDP-to-GTP exchange factor of Ran: implications for the mechanism of nuclear import. J Biol Chem 284: 22549-58 PubMed GONUTS page
  2. 2.0 2.1 Rout MP et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148: 635-51 PubMed GONUTS page
  3. 3.0 3.1 3.2 MacKinnon MA et al. (2009) The Kap60-Kap95 karyopherin complex directly regulates phosphatidylcholine synthesis. J Biol Chem 284: 7376-84 PubMed GONUTS page
  4. King MC et al. (2006) Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 442: 1003-7 PubMed GONUTS page
  5. Enenkel C et al. (1995) Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes. J Biol Chem 270: 16499-502 PubMed GONUTS page
  6. De Hertogh B et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2: 154-70 PubMed GONUTS page
  7. Ryan KJ et al. (2007) The karyopherin Kap95 regulates nuclear pore complex assembly into intact nuclear envelopes in vivo. Mol Biol Cell 18: 886-98 PubMed GONUTS page
  8. Makhnevych T et al. (2007) The role of karyopherins in the regulated sumoylation of septins. J Cell Biol 177: 39-49 PubMed GONUTS page
  9. Synowsky SA et al. (2009) Comparative multiplexed mass spectrometric analyses of endogenously expressed yeast nuclear and cytoplasmic exosomes. J Mol Biol 385: 1300-13 PubMed GONUTS page
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