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SGD:KAE1

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Contents

Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) KAE1 ( synonyms: YKR038C )
Protein Name(s) Highly conserved ATPase of HSP70/DnaK family,
External Links
SGD S000001746

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000408

EKC/KEOPS complex

SGD_REF:S000114691
PMID:16564010[1]

IDA: Inferred from Direct Assay

C

From SGD

GO:0000408

EKC/KEOPS complex

SGD_REF:S000117374
PMID:16874308[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0000723

telomere maintenance

SGD_REF:S000114691
PMID:16564010[1]

IPI: Inferred from Physical Interaction

SGD:S000003494

P

From SGD

GO:0000781

chromosome, telomeric region

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0779

C

From SGD

GO:0000781

chromosome, telomeric region

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0276

C

From SGD

GO:0004222

metalloendopeptidase activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR017860
InterPro:IPR000905
InterPro:IPR017861

F

From SGD

GO:0005634

nucleus

SGD_REF:S000074185
PMID:14562095[3]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005634

nucleus

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

From SGD

GO:0005634

nucleus

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

From SGD

GO:0005694

chromosome

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0158

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000074185
PMID:14562095[3]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

From SGD

GO:0006351

transcription, DNA-dependent

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From SGD

GO:0006355

regulation of transcription, DNA-dependent

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

From SGD

GO:0006508

proteolysis

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR017860
InterPro:IPR000905
InterPro:IPR017861

P

From SGD

GO:0008033

tRNA processing

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0819

P

From SGD

GO:0031490

chromatin DNA binding

SGD_REF:S000117374
PMID:16874308[2]

IDA: Inferred from Direct Assay

F

From SGD

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

SGD_REF:S000117374
PMID:16874308[2]

IPI: Inferred from Physical Interaction

SGD:S000028512

P

From SGD

GO:0046872

metal ion binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From SGD

GO:0051276

chromosome organization

SGD_REF:S000126287
PMID:18439903[4]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0070525

threonylcarbamoyladenosine metabolic process

SGD_REF:S000142370
PMID:21183954[5]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0070525

threonylcarbamoyladenosine metabolic process

SGD_REF:S000147196
PMID:21459853[6]

IMP: Inferred from Mutant Phenotype

P

From SGD

colocalizes_with

GO:0000790

nuclear chromatin

SGD_REF:S000117374
PMID:16874308[2]

IDA: Inferred from Direct Assay

C

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Downey M et al. (2006) A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell 124: 1155-68 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Kisseleva-Romanova E et al. (2006) Yeast homolog of a cancer-testis antigen defines a new transcription complex. EMBO J 25: 3576-85 PubMed GONUTS page
  3. 3.0 3.1 Huh WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425: 686-91 PubMed GONUTS page
  4. Ben-Aroya S et al. (2008) Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30: 248-58 PubMed GONUTS page
  5. Srinivasan M et al. (2011) The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. EMBO J 30: 873-81 PubMed GONUTS page
  6. Daugeron MC et al. (2011) Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs. Nucleic Acids Res 39: 6148-60 PubMed GONUTS page
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