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SGD:GCD1

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Contents

Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) GCD1 ( synonyms: YOR260W, TRA3 )
Protein Name(s) Gamma subunit of the translation initiation factor eIF2B,
External Links
SGD S000005786

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003743

translation initiation factor activity

SGD_REF:S000054638
PMID:2038327[1]

IMP: Inferred from Mutant Phenotype

F

From SGD

GO:0003743

translation initiation factor activity

SGD_REF:S000054638
PMID:2038327[1]

IPI: Inferred from Physical Interaction

SGD:S000003315
SGD:S000003767
SGD:S000001734

F

From SGD

GO:0003743

translation initiation factor activity

SGD_REF:S000066197
PMID:11707417[2]

IMP: Inferred from Mutant Phenotype

F

From SGD

GO:0003743

translation initiation factor activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0396

F

From SGD

GO:0005851

eukaryotic translation initiation factor 2B complex

SGD_REF:S000048815
PMID:8506384[3]

IDA: Inferred from Direct Assay

C

From SGD

GO:0006412

translation

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0648

P

From SGD

GO:0006413

translational initiation

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0396

P

From SGD

GO:0006417

regulation of translation

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0810

P

From SGD

GO:0006446

regulation of translational initiation

SGD_REF:S000039767
PMID:1986242[4]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006446

regulation of translational initiation

SGD_REF:S000046065
PMID:3516411[5]

IGI: Inferred from Genetic Interaction

SGD:S000000735

P

From SGD

GO:0006446

regulation of translational initiation

SGD_REF:S000046065
PMID:3516411[5]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006446

regulation of translational initiation

SGD_REF:S000048815
PMID:8506384[3]

IDA: Inferred from Direct Assay

P

From SGD

GO:0006446

regulation of translational initiation

SGD_REF:S000049826
PMID:3915540[6]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006446

regulation of translational initiation

SGD_REF:S000054638
PMID:2038327[1]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0016740

transferase activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR011004

F

From SGD

GO:0032045

guanyl-nucleotide exchange factor complex

SGD_REF:S000048815
PMID:8506384[3]

IDA: Inferred from Direct Assay

C

From SGD

GO:0032045

guanyl-nucleotide exchange factor complex

SGD_REF:S000048920
PMID:9472020[7]

IDA: Inferred from Direct Assay

C

From SGD

GO:0032045

guanyl-nucleotide exchange factor complex

SGD_REF:S000048920
PMID:9472020[7]

IPI: Inferred from Physical Interaction

SGD:S000002619

C

From SGD

contributes_to

GO:0005085

guanyl-nucleotide exchange factor activity

SGD_REF:S000048815
PMID:8506384[3]

IDA: Inferred from Direct Assay

F

From SGD

contributes_to

GO:0005085

guanyl-nucleotide exchange factor activity

SGD_REF:S000048920
PMID:9472020[7]

IDA: Inferred from Direct Assay

F

From SGD

contributes_to

GO:0005085

guanyl-nucleotide exchange factor activity

SGD_REF:S000048920
PMID:9472020[7]

IPI: Inferred from Physical Interaction

SGD:S000002619

F

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Cigan AM et al. (1991) Complex formation by positive and negative translational regulators of GCN4. Mol Cell Biol 11: 3217-28 PubMed GONUTS page
  2. Ashe MP et al. (2001) A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols. EMBO J 20: 6464-74 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Cigan AM et al. (1993) A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast. Proc Natl Acad Sci U S A 90: 5350-4 PubMed GONUTS page
  4. Abastado JP et al. (1991) Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control. Mol Cell Biol 11: 486-96 PubMed GONUTS page
  5. 5.0 5.1 Mueller PP & Hinnebusch AG (1986) Multiple upstream AUG codons mediate translational control of GCN4. Cell 45: 201-7 PubMed GONUTS page
  6. Hinnebusch AG (1985) A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiae. Mol Cell Biol 5: 2349-60 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Pavitt GD et al. (1998) eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange. Genes Dev 12: 514-26 PubMed GONUTS page
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