SGD:DNA2

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000014	single-stranded DNA specific endodeoxyribonuclease activity	SGD_REF:S000053505 PMID:9756935^[1]	IDA: Inferred from Direct Assay		F	From SGD
	GO:0000166	nucleotide binding	SGD_REF:S000124038	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	From SGD
	GO:0000706	meiotic DNA double-strand break processing	SGD_REF:S000133105 PMID:20150422^[2]	IGI: Inferred from Genetic Interaction	SGD:S000004526 SGD:S000000981	P	From SGD
	GO:0000723	telomere maintenance	SGD_REF:S000074691 PMID:12024033^[3]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0000739	DNA strand annealing activity	SGD_REF:S000119199 PMID:17032657^[4]	IDA: Inferred from Direct Assay		F	From SGD
	GO:0000784	nuclear chromosome, telomeric region	SGD_REF:S000074691 PMID:12024033^[3]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0001302	replicative cell aging	SGD_REF:S000074686 PMID:12024027^[5]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0003677	DNA binding	SGD_REF:S000124036	IEA: Inferred from Electronic Annotation	InterPro:IPR014808	F	From SGD
	GO:0003677	DNA binding	SGD_REF:S000124038	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F	From SGD
	GO:0004003	ATP-dependent DNA helicase activity	SGD_REF:S000039689 PMID:7644470^[6]	IDA: Inferred from Direct Assay		F	From SGD
	GO:0004003	ATP-dependent DNA helicase activity	SGD_REF:S000124036	IEA: Inferred from Electronic Annotation	InterPro:IPR014808	F	From SGD
	GO:0004386	helicase activity	SGD_REF:S000124038	IEA: Inferred from Electronic Annotation	SP_KW:KW-0347	F	From SGD
	GO:0005524	ATP binding	SGD_REF:S000124036	IEA: Inferred from Electronic Annotation	InterPro:IPR014808	F	From SGD
	GO:0005524	ATP binding	SGD_REF:S000124038	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	From SGD
	GO:0005634	nucleus	SGD_REF:S000130607 PMID:19520826^[7]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0005737	cytoplasm	SGD_REF:S000130607 PMID:19520826^[7]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0006260	DNA replication	SGD_REF:S000124036	IEA: Inferred from Electronic Annotation	InterPro:IPR014808	P	From SGD
	GO:0006260	DNA replication	SGD_REF:S000124038	IEA: Inferred from Electronic Annotation	SP_KW:KW-0235	P	From SGD
	GO:0006261	DNA-dependent DNA replication	SGD_REF:S000044982 PMID:9710536^[8]	IDA: Inferred from Direct Assay		P	From SGD
	GO:0006261	DNA-dependent DNA replication	SGD_REF:S000049830 PMID:7592912^[9]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0006273	lagging strand elongation	SGD_REF:S000046654 PMID:10101169^[10]	IGI: Inferred from Genetic Interaction		P	From SGD
	GO:0006273	lagging strand elongation	SGD_REF:S000046654 PMID:10101169^[10]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0006273	lagging strand elongation	SGD_REF:S000048574 PMID:10330154^[11]	IGI: Inferred from Genetic Interaction		P	From SGD
	GO:0006273	lagging strand elongation	SGD_REF:S000048574 PMID:10330154^[11]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0006281	DNA repair	SGD_REF:S000046654 PMID:10101169^[10]	IGI: Inferred from Genetic Interaction		P	From SGD
	GO:0006281	DNA repair	SGD_REF:S000046654 PMID:10101169^[10]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0016787	hydrolase activity	SGD_REF:S000124038	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F	From SGD
	GO:0017108	5'-flap endonuclease activity	SGD_REF:S000080373 PMID:15448135^[12]	IDA: Inferred from Direct Assay		F	From SGD
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bae SH et al. (1998) Dna2 of Saccharomyces cerevisiae possesses a single-stranded DNA-specific endonuclease activity that is able to act on double-stranded DNA in the presence of ATP. J Biol Chem 273: 26880-90 PubMed GONUTS page
↑ Manfrini N et al. (2010) Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases. J Biol Chem 285: 11628-37 PubMed GONUTS page
↑ ^3.0 ^3.1 Choe W et al. (2002) Dynamic localization of an Okazaki fragment processing protein suggests a novel role in telomere replication. Mol Cell Biol 22: 4202-17 PubMed GONUTS page
↑ Masuda-Sasa T et al. (2006) Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation. J Biol Chem 281: 38555-64 PubMed GONUTS page
↑ Hoopes LL et al. (2002) Mutations in DNA replication genes reduce yeast life span. Mol Cell Biol 22: 4136-46 PubMed GONUTS page
↑ Budd ME & Campbell JL (1995) A yeast gene required for DNA replication encodes a protein with homology to DNA helicases. Proc Natl Acad Sci U S A 92: 7642-6 PubMed GONUTS page
↑ ^7.0 ^7.1 Kosugi S et al. (2009) Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs. Proc Natl Acad Sci U S A 106: 10171-6 PubMed GONUTS page
↑ Braguglia D et al. (1998) Semi-conservative replication in yeast nuclear extracts requires Dna2 helicase and supercoiled template. J Mol Biol 281: 631-49 PubMed GONUTS page
↑ Budd ME et al. (1995) DNA2 encodes a DNA helicase essential for replication of eukaryotic chromosomes. J Biol Chem 270: 26766-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Formosa T & Nittis T (1999) Dna2 mutants reveal interactions with Dna polymerase alpha and Ctf4, a Pol alpha accessory factor, and show that full Dna2 helicase activity is not essential for growth. Genetics 151: 1459-70 PubMed GONUTS page
↑ ^11.0 ^11.1 Parenteau J & Wellinger RJ (1999) Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27. Mol Cell Biol 19: 4143-52 PubMed GONUTS page
↑ Kao HI et al. (2004) Dna2p helicase/nuclease is a tracking protein, like FEN1, for flap cleavage during Okazaki fragment maturation. J Biol Chem 279: 50840-9 PubMed GONUTS page

[PMID:9756935-0] Bae SH et al. (1998) Dna2 of Saccharomyces cerevisiae possesses a single-stranded DNA-specific endonuclease activity that is able to act on double-stranded DNA in the presence of ATP. J Biol Chem 273: 26880-90 PubMed GONUTS page

[PMID:20150422-1] Manfrini N et al. (2010) Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases. J Biol Chem 285: 11628-37 PubMed GONUTS page

[PMID:12024033-2] 3.0 ^3.1 Choe W et al. (2002) Dynamic localization of an Okazaki fragment processing protein suggests a novel role in telomere replication. Mol Cell Biol 22: 4202-17 PubMed GONUTS page

[PMID:17032657-3] Masuda-Sasa T et al. (2006) Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation. J Biol Chem 281: 38555-64 PubMed GONUTS page

[PMID:12024027-4] Hoopes LL et al. (2002) Mutations in DNA replication genes reduce yeast life span. Mol Cell Biol 22: 4136-46 PubMed GONUTS page

[PMID:7644470-5] Budd ME & Campbell JL (1995) A yeast gene required for DNA replication encodes a protein with homology to DNA helicases. Proc Natl Acad Sci U S A 92: 7642-6 PubMed GONUTS page

[PMID:19520826-6] 7.0 ^7.1 Kosugi S et al. (2009) Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs. Proc Natl Acad Sci U S A 106: 10171-6 PubMed GONUTS page

[PMID:9710536-7] Braguglia D et al. (1998) Semi-conservative replication in yeast nuclear extracts requires Dna2 helicase and supercoiled template. J Mol Biol 281: 631-49 PubMed GONUTS page

[PMID:7592912-8] Budd ME et al. (1995) DNA2 encodes a DNA helicase essential for replication of eukaryotic chromosomes. J Biol Chem 270: 26766-9 PubMed GONUTS page

[PMID:10101169-9] 10.0 ^10.1 ^10.2 ^10.3 Formosa T & Nittis T (1999) Dna2 mutants reveal interactions with Dna polymerase alpha and Ctf4, a Pol alpha accessory factor, and show that full Dna2 helicase activity is not essential for growth. Genetics 151: 1459-70 PubMed GONUTS page

[PMID:10330154-10] 11.0 ^11.1 Parenteau J & Wellinger RJ (1999) Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27. Mol Cell Biol 19: 4143-52 PubMed GONUTS page

[PMID:15448135-11] Kao HI et al. (2004) Dna2p helicase/nuclease is a tracking protein, like FEN1, for flap cleavage during Okazaki fragment maturation. J Biol Chem 279: 50840-9 PubMed GONUTS page

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Species (Taxon ID)	Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s)	DNA2 ( synonyms: YHR164C, WEB2 )
Protein Name(s)	DNA replication factor with ATPase, nuclease, and helicase activities,
External Links
SGD	S000001207

SGD:DNA2

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References

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