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SGD:CDC48
Contents |
| Species (Taxon ID) | Saccharomyces cerevisiae (baker's yeast) (taxon:4932) | |
| Gene Name(s) | CDC48 ( synonyms: YDL126C ) | |
| Protein Name(s) | ATPase involved in ubiquitin-mediated protein degradation, | |
| External Links | ||
| SGD | S000002284 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0000166 |
nucleotide binding |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From SGD |
||
| GO:0000278 |
mitotic cell cycle |
SGD_REF:S000045449 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0000837 |
Doa10p ubiquitin ligase complex |
SGD_REF:S000117399 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005524 |
ATP binding |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0005524 |
ATP binding |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From SGD |
||
| GO:0005634 |
nucleus |
SGD_REF:S000047715 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005783 |
endoplasmic reticulum |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0256 |
C |
From SGD |
||
| GO:0005783 |
endoplasmic reticulum |
SGD_REF:S000148671 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0095 |
C |
From SGD |
||
| GO:0005789 |
endoplasmic reticulum membrane |
SGD_REF:S000086063 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005792 |
microsome |
SGD_REF:S000055149 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005792 |
microsome |
SGD_REF:S000148671 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0166 |
C |
From SGD |
||
| GO:0005829 |
cytosol |
SGD_REF:S000069082 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005829 |
cytosol |
SGD_REF:S000086063 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0006511 |
ubiquitin-dependent protein catabolic process |
SGD_REF:S000049317 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0006511 |
ubiquitin-dependent protein catabolic process |
SGD_REF:S000049317 |
IPI: Inferred from Physical Interaction |
P |
From SGD |
|||
| GO:0006810 |
transport |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0813 |
P |
From SGD |
||
| GO:0006906 |
vesicle fusion |
SGD_REF:S000057372 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0007049 |
cell cycle |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0131 |
P |
From SGD |
||
| GO:0015031 |
protein transport |
SGD_REF:S000069082 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0015031 |
protein transport |
SGD_REF:S000148669 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0653 |
P |
From SGD |
||
| GO:0016236 |
macroautophagy |
SGD_REF:S000136710 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0016787 |
hydrolase activity |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0016887 |
ATPase activity |
SGD_REF:S000042102 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0017111 |
nucleoside-triphosphatase activity |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0030433 |
ER-associated protein catabolic process |
SGD_REF:S000069104 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0031134 |
sister chromatid biorientation |
SGD_REF:S000134141 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0034098 |
Cdc48p-Npl4p-Ufd1p AAA ATPase complex |
SGD_REF:S000086792 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0034727 |
piecemeal microautophagy of nucleus |
SGD_REF:S000136710 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0043332 |
mating projection tip |
SGD_REF:S000128539 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0071629 |
cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process |
SGD_REF:S000127825 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
| GO:0072671 |
mitochondria-associated protein catabolic process |
SGD_REF:S000140158 |
IMP: Inferred from Mutant Phenotype |
P |
From SGD |
|||
|
colocalizes_with |
GO:0005739 |
mitochondrion |
SGD_REF:S000140158 |
IDA: Inferred from Direct Assay |
C |
From SGD |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Moir D et al. (1982) Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies. Genetics 100: 547-63 PubMed GONUTS page
- ↑ Carvalho P et al. (2006) Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell 126: 361-73 PubMed GONUTS page
- ↑ Madeo F et al. (1998) Tyrosine phosphorylation regulates cell cycle-dependent nuclear localization of Cdc48p. Mol Biol Cell 9: 131-41 PubMed GONUTS page
- ↑ 4.0 4.1 Nita-Lazar M & Lennarz WJ (2005) Pkc1p modifies CPY* degradation in the ERAD pathway. Biochem Biophys Res Commun 332: 357-61 PubMed GONUTS page
- ↑ Fröhlich KU et al. (1991) Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression. J Cell Biol 114: 443-53 PubMed GONUTS page
- ↑ 6.0 6.1 Ye Y et al. (2001) The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature 414: 652-6 PubMed GONUTS page
- ↑ 7.0 7.1 Ghislain M et al. (1996) Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cerevisiae. EMBO J 15: 4884-99 PubMed GONUTS page
- ↑ Latterich M et al. (1995) Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes. Cell 82: 885-93 PubMed GONUTS page
- ↑ 9.0 9.1 Krick R et al. (2010) Cdc48/p97 and Shp1/p47 regulate autophagosome biogenesis in concert with ubiquitin-like Atg8. J Cell Biol 190: 965-73 PubMed GONUTS page
- ↑ Fröhlich KU et al. (1995) The ATPase activity of purified CDC48p from Saccharomyces cerevisiae shows complex dependence on ATP-, ADP-, and NADH-concentrations and is completely inhibited by NEM. Biochim Biophys Acta 1253: 25-32 PubMed GONUTS page
- ↑ Rabinovich E et al. (2002) AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation. Mol Cell Biol 22: 626-34 PubMed GONUTS page
- ↑ Cheng YL & Chen RH (2010) The AAA-ATPase Cdc48 and cofactor Shp1 promote chromosome bi-orientation by balancing Aurora B activity. J Cell Sci 123: 2025-34 PubMed GONUTS page
- ↑ Schuberth C & Buchberger A (2005) Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation. Nat Cell Biol 7: 999-1006 PubMed GONUTS page
- ↑ Narayanaswamy R et al. (2009) Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast. J Proteome Res 8: 6-19 PubMed GONUTS page
- ↑ Metzger MB et al. (2008) Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery. J Biol Chem 283: 32302-16 PubMed GONUTS page
- ↑ 16.0 16.1 Heo JM et al. (2010) A stress-responsive system for mitochondrial protein degradation. Mol Cell 40: 465-80 PubMed GONUTS page
