SGD:CDC28

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From SGD
	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	SGD_REF:S000043997 PMID:1849458^[1]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	SGD_REF:S000055055 PMID:2142620^[2]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0004672	protein kinase activity	SGD_REF:S000113918 PMID:16319894^[3]	IDA: Inferred from Direct Assay		F	From SGD
	GO:0004672	protein kinase activity	SGD_REF:S000124036	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR002290	F	From SGD
	GO:0004674	protein serine/threonine kinase activity	SGD_REF:S000124036	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F	From SGD
	GO:0004674	protein serine/threonine kinase activity	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0723	F	From SGD
	GO:0004693	cyclin-dependent protein kinase activity	SGD_REF:S000055055 PMID:2142620^[2]	IDA: Inferred from Direct Assay		F	From SGD
	GO:0004693	cyclin-dependent protein kinase activity	SGD_REF:S000124037	IEA: Inferred from Electronic Annotation	EC:2.7.11.22	F	From SGD
	GO:0005524	ATP binding	SGD_REF:S000124036	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR017441 InterPro:IPR002290	F	From SGD
	GO:0005524	ATP binding	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From SGD
	GO:0005634	nucleus	SGD_REF:S000076346 PMID:14685274^[4]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0005737	cytoplasm	SGD_REF:S000044622 PMID:3312233^[5]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0005783	endoplasmic reticulum	SGD_REF:S000123048 PMID:17560371^[6]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0005935	cellular bud neck	SGD_REF:S000072836 PMID:12554645^[7]	IDA: Inferred from Direct Assay		C	From SGD
	GO:0006338	chromatin remodeling	SGD_REF:S000136817 PMID:20855529^[8]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0006468	protein phosphorylation	SGD_REF:S000041807 PMID:3889921^[9]	IDA: Inferred from Direct Assay		P	From SGD
	GO:0006468	protein phosphorylation	SGD_REF:S000041807 PMID:3889921^[9]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0006468	protein phosphorylation	SGD_REF:S000113918 PMID:16319894^[3]	IDA: Inferred from Direct Assay		P	From SGD
	GO:0006468	protein phosphorylation	SGD_REF:S000124036	IEA: Inferred from Electronic Annotation	InterPro:IPR002290 InterPro:IPR008271 InterPro:IPR000719	P	From SGD
	GO:0007049	cell cycle	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0131	P	From SGD
	GO:0007067	mitosis	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0498	P	From SGD
	GO:0010568	regulation of budding cell apical bud growth	SGD_REF:S000122433 PMID:17417630^[10]	IGI: Inferred from Genetic Interaction	SGD:S000003723	P	From SGD
	GO:0010568	regulation of budding cell apical bud growth	SGD_REF:S000122433 PMID:17417630^[10]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0010569	regulation of double-strand break repair via homologous recombination	SGD_REF:S000079871 PMID:15496928^[11]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0010570	regulation of filamentous growth	SGD_REF:S000041353 PMID:9891070^[12]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0010571	positive regulation of DNA replication involved in S phase	SGD_REF:S000073655 PMID:12783856^[13]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0010571	positive regulation of DNA replication involved in S phase	SGD_REF:S000078503 PMID:14747467^[14]	IDA: Inferred from Direct Assay		P	From SGD
	GO:0010571	positive regulation of DNA replication involved in S phase	SGD_REF:S000078503 PMID:14747467^[14]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0010571	positive regulation of DNA replication involved in S phase	SGD_REF:S000120479 PMID:4580573^[15]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0010696	positive regulation of spindle pole body separation	SGD_REF:S000043278 PMID:8887667^[16]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0010696	positive regulation of spindle pole body separation	SGD_REF:S000115566 PMID:16688214^[17]	IGI: Inferred from Genetic Interaction	SGD:S000000787 SGD:S000005584 SGD:S000000159	P	From SGD
	GO:0010696	positive regulation of spindle pole body separation	SGD_REF:S000115566 PMID:16688214^[17]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0010898	positive regulation of triglyceride catabolic process	SGD_REF:S000129072 PMID:19150427^[18]	IGI: Inferred from Genetic Interaction	SGD:S000001797	P	From SGD
	GO:0010898	positive regulation of triglyceride catabolic process	SGD_REF:S000129072 PMID:19150427^[18]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0016301	kinase activity	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From SGD
	GO:0016310	phosphorylation	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From SGD
	GO:0016740	transferase activity	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From SGD
	GO:0016772	transferase activity, transferring phosphorus-containing groups	SGD_REF:S000124036	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From SGD
	GO:0042393	histone binding	SGD_REF:S000136817 PMID:20855529^[8]	IDA: Inferred from Direct Assay		F	From SGD
	GO:0045892	negative regulation of transcription, DNA-dependent	SGD_REF:S000070250 PMID:12081645^[19]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0045892	negative regulation of transcription, DNA-dependent	SGD_REF:S000075752 PMID:14993267^[20]	IDA: Inferred from Direct Assay		P	From SGD
	GO:0045892	negative regulation of transcription, DNA-dependent	SGD_REF:S000075752 PMID:14993267^[20]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0045893	positive regulation of transcription, DNA-dependent	SGD_REF:S000041330 PMID:1652372^[21]	IDA: Inferred from Direct Assay		P	From SGD
	GO:0045893	positive regulation of transcription, DNA-dependent	SGD_REF:S000041330 PMID:1652372^[21]	IGI: Inferred from Genetic Interaction	SGD:S000002553	P	From SGD
	GO:0045930	negative regulation of mitotic cell cycle	SGD_REF:S000053884 PMID:10074450^[22]	IDA: Inferred from Direct Assay		P	From SGD
	GO:0045931	positive regulation of mitotic cell cycle	SGD_REF:S000043253 PMID:7002718^[23]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0045931	positive regulation of mitotic cell cycle	SGD_REF:S000049304 PMID:2165600^[24]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0051301	cell division	SGD_REF:S000148669	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0132	P	From SGD
	GO:0051446	positive regulation of meiotic cell cycle	SGD_REF:S000041086 PMID:2680756^[25]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0051446	positive regulation of meiotic cell cycle	SGD_REF:S000117195 PMID:16814718^[26]	IDA: Inferred from Direct Assay		P	From SGD
	GO:0051446	positive regulation of meiotic cell cycle	SGD_REF:S000117195 PMID:16814718^[26]	IMP: Inferred from Mutant Phenotype		P	From SGD
	GO:0051447	negative regulation of meiotic cell cycle	SGD_REF:S000070250 PMID:12081645^[19]	IMP: Inferred from Mutant Phenotype		P	From SGD
colocalizes_with	GO:0000235	astral microtubule	SGD_REF:S000077094 PMID:15256500^[27]	IDA: Inferred from Direct Assay		C	From SGD
colocalizes_with	GO:0005816	spindle pole body	SGD_REF:S000072836 PMID:12554645^[7]	IDA: Inferred from Direct Assay		C	From SGD
colocalizes_with	GO:0005840	ribosome	SGD_REF:S000115662 PMID:16702403^[28]	IDA: Inferred from Direct Assay		C	From SGD
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ghiara JB et al. (1991) A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis. Cell 65: 163-74 PubMed GONUTS page
↑ ^2.0 ^2.1 Wittenberg C et al. (1990) G1-specific cyclins of S. cerevisiae: cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase. Cell 62: 225-37 PubMed GONUTS page
↑ ^3.0 ^3.1 Ptacek J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438: 679-84 PubMed GONUTS page
↑ Wang H et al. (2004) Recruitment of Cdc28 by Whi3 restricts nuclear accumulation of the G1 cyclin-Cdk complex to late G1. EMBO J 23: 180-90 PubMed GONUTS page
↑ Wittenberg C et al. (1987) Subcellular localization of a protein kinase required for cell cycle initiation in Saccharomyces cerevisiae: evidence for an association between the CDC28 gene product and the insoluble cytoplasmic matrix. J Cell Biol 105: 1527-38 PubMed GONUTS page
↑ Vergés E et al. (2007) Cyclin Cln3 is retained at the ER and released by the J chaperone Ydj1 in late G1 to trigger cell cycle entry. Mol Cell 26: 649-62 PubMed GONUTS page
↑ ^7.0 ^7.1 Maekawa H et al. (2003) Yeast Cdk1 translocates to the plus end of cytoplasmic microtubules to regulate bud cortex interactions. EMBO J 22: 438-49 PubMed GONUTS page
↑ ^8.0 ^8.1 Chaves S et al. (2010) Cks1, Cdk1, and the 19S proteasome collaborate to regulate gene induction-dependent nucleosome eviction in yeast. Mol Cell Biol 30: 5284-94 PubMed GONUTS page
↑ ^9.0 ^9.1 Reed SI et al. (1985) Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28. Proc Natl Acad Sci U S A 82: 4055-9 PubMed GONUTS page
↑ ^10.0 ^10.1 McCusker D et al. (2007) Cdk1 coordinates cell-surface growth with the cell cycle. Nat Cell Biol 9: 506-15 PubMed GONUTS page
↑ Ira G et al. (2004) DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431: 1011-7 PubMed GONUTS page
↑ Edgington NP et al. (1999) Control of Saccharomyces cerevisiae filamentous growth by cyclin-dependent kinase Cdc28. Mol Cell Biol 19: 1369-80 PubMed GONUTS page
↑ Benjamin KR et al. (2003) Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2. Genes Dev 17: 1524-39 PubMed GONUTS page
↑ ^14.0 ^14.1 Kesti T et al. (2004) Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase. J Biol Chem 279: 14245-55 PubMed GONUTS page
↑ Hartwell LH (1973) Three additional genes required for deoxyribonucleic acid synthesis in Saccharomyces cerevisiae. J Bacteriol 115: 966-74 PubMed GONUTS page
↑ Lim HH et al. (1996) Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28. Mol Cell Biol 16: 6385-97 PubMed GONUTS page
↑ ^17.0 ^17.1 Crasta K et al. (2006) Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins. EMBO J 25: 2551-63 PubMed GONUTS page
↑ ^18.0 ^18.1 Kurat CF et al. (2009) Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Mol Cell 33: 53-63 PubMed GONUTS page
↑ ^19.0 ^19.1 Purnapatre K et al. (2002) The CLN3/SWI6/CLN2 pathway and SNF1 act sequentially to regulate meiotic initiation in Saccharomyces cerevisiae. Genes Cells 7: 675-91 PubMed GONUTS page
↑ ^20.0 ^20.1 Geymonat M et al. (2004) Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6. Mol Cell Biol 24: 2277-85 PubMed GONUTS page
↑ ^21.0 ^21.1 Moll T et al. (1991) The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. Cell 66: 743-58 PubMed GONUTS page
↑ Jaspersen SL et al. (1999) Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr Biol 9: 227-36 PubMed GONUTS page
↑ Reed SI (1980) The selection of S. cerevisiae mutants defective in the start event of cell division. Genetics 95: 561-77 PubMed GONUTS page
↑ Reed SI & Wittenberg C (1990) Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 87: 5697-701 PubMed GONUTS page
↑ Shuster EO & Byers B (1989) Pachytene arrest and other meiotic effects of the start mutations in Saccharomyces cerevisiae. Genetics 123: 29-43 PubMed GONUTS page
↑ ^26.0 ^26.1 Henderson KA et al. (2006) Cyclin-dependent kinase directly regulates initiation of meiotic recombination. Cell 125: 1321-32 PubMed GONUTS page
↑ Maekawa H & Schiebel E (2004) Cdk1-Clb4 controls the interaction of astral microtubule plus ends with subdomains of the daughter cell cortex. Genes Dev 18: 1709-24 PubMed GONUTS page
↑ Fleischer TC et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20: 1294-307 PubMed GONUTS page

[PMID:1849458-0] Ghiara JB et al. (1991) A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis. Cell 65: 163-74 PubMed GONUTS page

[PMID:2142620-1] 2.0 ^2.1 Wittenberg C et al. (1990) G1-specific cyclins of S. cerevisiae: cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase. Cell 62: 225-37 PubMed GONUTS page

[PMID:16319894-2] 3.0 ^3.1 Ptacek J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438: 679-84 PubMed GONUTS page

[PMID:14685274-3] Wang H et al. (2004) Recruitment of Cdc28 by Whi3 restricts nuclear accumulation of the G1 cyclin-Cdk complex to late G1. EMBO J 23: 180-90 PubMed GONUTS page

[PMID:3312233-4] Wittenberg C et al. (1987) Subcellular localization of a protein kinase required for cell cycle initiation in Saccharomyces cerevisiae: evidence for an association between the CDC28 gene product and the insoluble cytoplasmic matrix. J Cell Biol 105: 1527-38 PubMed GONUTS page

[PMID:17560371-5] Vergés E et al. (2007) Cyclin Cln3 is retained at the ER and released by the J chaperone Ydj1 in late G1 to trigger cell cycle entry. Mol Cell 26: 649-62 PubMed GONUTS page

[PMID:12554645-6] 7.0 ^7.1 Maekawa H et al. (2003) Yeast Cdk1 translocates to the plus end of cytoplasmic microtubules to regulate bud cortex interactions. EMBO J 22: 438-49 PubMed GONUTS page

[PMID:20855529-7] 8.0 ^8.1 Chaves S et al. (2010) Cks1, Cdk1, and the 19S proteasome collaborate to regulate gene induction-dependent nucleosome eviction in yeast. Mol Cell Biol 30: 5284-94 PubMed GONUTS page

[PMID:3889921-8] 9.0 ^9.1 Reed SI et al. (1985) Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28. Proc Natl Acad Sci U S A 82: 4055-9 PubMed GONUTS page

[PMID:17417630-9] 10.0 ^10.1 McCusker D et al. (2007) Cdk1 coordinates cell-surface growth with the cell cycle. Nat Cell Biol 9: 506-15 PubMed GONUTS page

[PMID:15496928-10] Ira G et al. (2004) DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431: 1011-7 PubMed GONUTS page

[PMID:9891070-11] Edgington NP et al. (1999) Control of Saccharomyces cerevisiae filamentous growth by cyclin-dependent kinase Cdc28. Mol Cell Biol 19: 1369-80 PubMed GONUTS page

[PMID:12783856-12] Benjamin KR et al. (2003) Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2. Genes Dev 17: 1524-39 PubMed GONUTS page

[PMID:14747467-13] 14.0 ^14.1 Kesti T et al. (2004) Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase. J Biol Chem 279: 14245-55 PubMed GONUTS page

[PMID:4580573-14] Hartwell LH (1973) Three additional genes required for deoxyribonucleic acid synthesis in Saccharomyces cerevisiae. J Bacteriol 115: 966-74 PubMed GONUTS page

[PMID:8887667-15] Lim HH et al. (1996) Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28. Mol Cell Biol 16: 6385-97 PubMed GONUTS page

[PMID:16688214-16] 17.0 ^17.1 Crasta K et al. (2006) Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins. EMBO J 25: 2551-63 PubMed GONUTS page

[PMID:19150427-17] 18.0 ^18.1 Kurat CF et al. (2009) Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Mol Cell 33: 53-63 PubMed GONUTS page

[PMID:12081645-18] 19.0 ^19.1 Purnapatre K et al. (2002) The CLN3/SWI6/CLN2 pathway and SNF1 act sequentially to regulate meiotic initiation in Saccharomyces cerevisiae. Genes Cells 7: 675-91 PubMed GONUTS page

[PMID:14993267-19] 20.0 ^20.1 Geymonat M et al. (2004) Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6. Mol Cell Biol 24: 2277-85 PubMed GONUTS page

[PMID:1652372-20] 21.0 ^21.1 Moll T et al. (1991) The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. Cell 66: 743-58 PubMed GONUTS page

[PMID:10074450-21] Jaspersen SL et al. (1999) Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr Biol 9: 227-36 PubMed GONUTS page

[PMID:7002718-22] Reed SI (1980) The selection of S. cerevisiae mutants defective in the start event of cell division. Genetics 95: 561-77 PubMed GONUTS page

[PMID:2165600-23] Reed SI & Wittenberg C (1990) Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 87: 5697-701 PubMed GONUTS page

[PMID:2680756-24] Shuster EO & Byers B (1989) Pachytene arrest and other meiotic effects of the start mutations in Saccharomyces cerevisiae. Genetics 123: 29-43 PubMed GONUTS page

[PMID:16814718-25] 26.0 ^26.1 Henderson KA et al. (2006) Cyclin-dependent kinase directly regulates initiation of meiotic recombination. Cell 125: 1321-32 PubMed GONUTS page

[PMID:15256500-26] Maekawa H & Schiebel E (2004) Cdk1-Clb4 controls the interaction of astral microtubule plus ends with subdomains of the daughter cell cortex. Genes Dev 18: 1709-24 PubMed GONUTS page

[PMID:16702403-27] Fleischer TC et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20: 1294-307 PubMed GONUTS page

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Species (Taxon ID)	Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s)	CDC28 ( synonyms: YBR160W, CDK1, HSL5, SRM5 )
Protein Name(s)	Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK),
External Links
SGD	S000000364

SGD:CDC28

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