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SGD:APN1
Contents |
| Species (Taxon ID) | Saccharomyces cerevisiae (baker's yeast) (taxon:4932) | |
| Gene Name(s) | APN1 ( synonyms: YKL114C ) | |
| Protein Name(s) | Major apurinic/apyrimidinic endonuclease, | |
| External Links | ||
| SGD | S000001597 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003677 |
DNA binding |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0003906 |
DNA-(apurinic or apyrimidinic site) lyase activity |
SGD_REF:S000039558 |
IMP: Inferred from Mutant Phenotype |
F |
From SGD |
|||
| GO:0003906 |
DNA-(apurinic or apyrimidinic site) lyase activity |
SGD_REF:S000039558 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From SGD |
|||
| GO:0003906 |
DNA-(apurinic or apyrimidinic site) lyase activity |
SGD_REF:S000073336 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0003906 |
DNA-(apurinic or apyrimidinic site) lyase activity |
SGD_REF:S000124037 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0004519 |
endonuclease activity |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0005622 |
intracellular |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
C |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000050884 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000124038 |
IEA: Inferred from Electronic Annotation |
C |
From SGD |
|||
| GO:0005634 |
nucleus |
SGD_REF:S000125578 |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
From SGD |
||
| GO:0005739 |
mitochondrion |
SGD_REF:S000060116 |
IDA: Inferred from Direct Assay |
C |
From SGD |
|||
| GO:0006281 |
DNA repair |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0006281 |
DNA repair |
SGD_REF:S000124038 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0006284 |
base-excision repair |
SGD_REF:S000051442 |
IDA: Inferred from Direct Assay |
P |
From SGD |
|||
| GO:0006974 |
response to DNA damage stimulus |
SGD_REF:S000124038 |
IEA: Inferred from Electronic Annotation |
P |
From SGD |
|||
| GO:0008081 |
phosphoric diester hydrolase activity |
SGD_REF:S000052264 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0008270 |
zinc ion binding |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0008311 |
double-stranded DNA specific 3'-5' exodeoxyribonuclease activity |
SGD_REF:S000082522 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0008833 |
deoxyribonuclease IV (phage-T4-induced) activity |
SGD_REF:S000124036 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0016829 |
lyase activity |
SGD_REF:S000124038 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
|||
| GO:0017005 |
3'-tyrosyl-DNA phosphodiesterase activity |
SGD_REF:S000072272 |
IDA: Inferred from Direct Assay |
F |
From SGD |
|||
| GO:0046872 |
metal ion binding |
SGD_REF:S000124038 |
IEA: Inferred from Electronic Annotation |
F |
From SGD |
| ||
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Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Popoff SC et al. (1990) Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV. Proc Natl Acad Sci U S A 87: 4193-7 PubMed GONUTS page
- ↑ Jilani A et al. (2003) Characterization of two independent amino acid substitutions that disrupt the DNA repair functions of the yeast Apn1. Biochemistry 42: 6436-45 PubMed GONUTS page
- ↑ Ramotar D et al. (1993) Intracellular localization of the Apn1 DNA repair enzyme of Saccharomyces cerevisiae. Nuclear transport signals and biological role. J Biol Chem 268: 20533-9 PubMed GONUTS page
- ↑ Vongsamphanh R et al. (2001) Pir1p mediates translocation of the yeast Apn1p endonuclease into the mitochondria to maintain genomic stability. Mol Cell Biol 21: 1647-55 PubMed GONUTS page
- ↑ Wang Z et al. (1997) Molecular mechanism of base excision repair of uracil-containing DNA in yeast cell-free extracts. J Biol Chem 272: 24064-71 PubMed GONUTS page
- ↑ Johnson AW & Demple B (1988) Yeast DNA diesterase for 3'-fragments of deoxyribose: purification and physical properties of a repair enzyme for oxidative DNA damage. J Biol Chem 263: 18009-16 PubMed GONUTS page
- ↑ Ishchenko AA et al. (2005) The 3'->5' exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae. Mol Cell Biol 25: 6380-90 PubMed GONUTS page
- ↑ Liu C et al. (2002) Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1. Proc Natl Acad Sci U S A 99: 14970-5 PubMed GONUTS page
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