SGD:AFG3

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Contents

Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) AFG3 ( synonyms: YER017C, YTA10 )
Protein Name(s) Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes,
External Links
SGD S000000819

Annotations

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0000166

nucleotide binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

From SGD

GO:0000166

nucleotide binding

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

From SGD

GO:0004222

metalloendopeptidase activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000642
InterPro:IPR011546
InterPro:IPR005936

F

From SGD

GO:0005524

ATP binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR011546
InterPro:IPR003960
InterPro:IPR003959
InterPro:IPR000642

F

From SGD

GO:0005524

ATP binding

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

From SGD

GO:0005739

mitochondrion

SGD_REF:S000117178
PMID:16823961[1]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005739

mitochondrion

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0496

C

From SGD

GO:0005743

mitochondrial inner membrane

SGD_REF:S000050177
PMID:7926051[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005745

m-AAA complex

SGD_REF:S000055187
PMID:8681382[3]

IDA: Inferred from Direct Assay

C

From SGD

GO:0006461

protein complex assembly

SGD_REF:S000055187
PMID:8681382[3]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006465

signal peptide processing

SGD_REF:S000071826
PMID:12417197[4]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006508

proteolysis

SGD_REF:S000055187
PMID:8681382[3]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006508

proteolysis

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000642

P

From SGD

GO:0008233

peptidase activity

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0645

F

From SGD

GO:0008237

metallopeptidase activity

SGD_REF:S000055187
PMID:8681382[3]

IMP: Inferred from Mutant Phenotype

F

From SGD

GO:0008237

metallopeptidase activity

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0482

F

From SGD

GO:0008270

zinc ion binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR011546

F

From SGD

GO:0008270

zinc ion binding

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0862

F

From SGD

GO:0016020

membrane

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR005936

C

From SGD

GO:0016020

membrane

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

From SGD

GO:0016021

integral to membrane

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR011546

C

From SGD

GO:0016021

integral to membrane

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

From SGD

GO:0016787

hydrolase activity

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

From SGD

GO:0016887

ATPase activity

SGD_REF:S000053170
PMID:7900428[5]

ISS: Inferred from Sequence or Structural Similarity

F

From SGD

GO:0017111

nucleoside-triphosphatase activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

From SGD

GO:0030163

protein catabolic process

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR005936

P

From SGD

GO:0045041

protein import into mitochondrial intermembrane space

SGD_REF:S000071826
PMID:12417197[4]

TAS: Traceable Author Statement

P

From SGD

GO:0046872

metal ion binding

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

From SGD


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Notes

References

See Help:References for how to manage references in GONUTS.
  1. Reinders J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5: 1543-54 PubMed GONUTS page
  2. PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Arlt H et al. (1996) The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria. Cell 85: 875-85 PubMed GONUTS page
  4. 4.0 4.1 Esser K et al. (2002) A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative rhomboid protease Pcp1. J Mol Biol 323: 835-43 PubMed GONUTS page
  5. PubMed GONUTS page
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