SGD:ACS1

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Contents

Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) ACS1 ( synonyms: YAL054C, FUN44 )
Protein Name(s) Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation,
External Links
SGD S000000050

Annotations

QualifierGO IDGO term nameReference(s)Evidence Codewith/fromAspectNotesStatus
GO:0000166

nucleotide binding

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

From SGD

GO:0003824

catalytic activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000873

F

From SGD

GO:0003987

acetate-CoA ligase activity

SGD_REF:S000047927
PMID:8910545[1]

IDA: Inferred from Direct Assay

F

From SGD

GO:0003987

acetate-CoA ligase activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR011904

F

From SGD

GO:0003987

acetate-CoA ligase activity

SGD_REF:S000124037

IEA: Inferred from Electronic Annotation

EC:6.2.1.1

F

From SGD

GO:0005524

ATP binding

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

From SGD

GO:0005739

mitochondrion

SGD_REF:S000075100
PMID:14576278[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005739

mitochondrion

SGD_REF:S000117178
PMID:16823961[3]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005783

endoplasmic reticulum

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0256

C

From SGD

GO:0005783

endoplasmic reticulum

SGD_REF:S000125578

IEA: Inferred from Electronic Annotation

SP_SL:SL-0095

C

From SGD

GO:0005792

microsome

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0492

C

From SGD

GO:0005792

microsome

SGD_REF:S000125578

IEA: Inferred from Electronic Annotation

SP_SL:SL-0166

C

From SGD

GO:0005829

cytosol

SGD_REF:S000048464
PMID:9711835[4]

IDA: Inferred from Direct Assay

C

From SGD

GO:0006085

acetyl-CoA biosynthetic process

SGD_REF:S000047927
PMID:8910545[1]

IDA: Inferred from Direct Assay

P

From SGD

GO:0007039

vacuolar protein catabolic process

SGD_REF:S000131114

P

From SGD

GO:0008152

metabolic process

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000873

P

From SGD

GO:0016208

AMP binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR011904

F

From SGD

GO:0016573

histone acetylation

SGD_REF:S000117290
PMID:16857587[5]

IGI: Inferred from Genetic Interaction

SGD:S000004143

P

From SGD

GO:0016874

ligase activity

SGD_REF:S000124038

IEA: Inferred from Electronic Annotation

SP_KW:KW-0436

F

From SGD

GO:0019654

acetate fermentation

SGD_REF:S000047705
PMID:1363452[6]

IMP: Inferred from Mutant Phenotype

P

From SGD


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Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 van den Berg MA et al. (1996) The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation. J Biol Chem 271: 28953-9 PubMed GONUTS page
  2. Sickmann A et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100: 13207-12 PubMed GONUTS page
  3. Reinders J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5: 1543-54 PubMed GONUTS page
  4. de Jong-Gubbels P et al. (1998) Overproduction of acetyl-coenzyme A synthetase isoenzymes in respiring Saccharomyces cerevisiae cells does not reduce acetate production after exposure to glucose excess. FEMS Microbiol Lett 165: 15-20 PubMed GONUTS page
  5. Takahashi H et al. (2006) Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol Cell 23: 207-17 PubMed GONUTS page
  6. De Virgilio C et al. (1992) Cloning and disruption of a gene required for growth on acetate but not on ethanol: the acetyl-coenzyme A synthetase gene of Saccharomyces cerevisiae. Yeast 8: 1043-51 PubMed GONUTS page
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