Ambox notice.png

GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.

You can help reduce stress on the server by:

  1. not reloading pages frequently - this just adds
  2. opening links in new windows (so you can read the old page)

SCHPO:ATM

From GONUTS
Jump to: navigation, search

Contents

Species (Taxon ID) Schizosaccharomyces pombe (strain ATCC 38366 / 972) (Fission yeast). (taxon:284812)
Gene Name(s) tel1
Protein Name(s)
  • Serine/threonine-protein kinase tel1
  • ATM homolog
  • DNA-damage checkpoint kinase tel1
  • Telomere length regulation protein 1
External Links
UniProt Identifier ATM_SCHPO
UniProt Accessions O74630,
EMBL AB001995, CU329672,
PIR T43271,
RefSeq NP_588126.1,
Pfam PF02259, PF02260, PF00454, PF11640,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000781

chromosome, telomeric region

IEA: Inferred from Electronic Annotation

C

Source: UniProtKB-SubCell

GO:0005829

cytosol

IDA: Inferred from Direct Assay

C

Source: GeneDB_Spombe

GO:0005634

nucleus

IEA: Inferred from Electronic Annotation

C

Source: UniProtKB-SubCell

GO:0005524

ATP binding

IEA: Inferred from Electronic Annotation

F

Source: UniProtKB-KW

GO:0005515

protein binding

IPI: Inferred from Physical Interaction

F

Source: GeneDB_Spombe

GO:0004674

protein serine/threonine kinase activity

IEA: Inferred from Electronic Annotation

F

Source: UniProtKB-KW

GO:0006281

DNA repair

IEA: Inferred from Electronic Annotation

P

Source: UniProtKB-KW

GO:0016572

histone phosphorylation

IGI: Inferred from Genetic Interaction

P

Source: GeneDB_Spombe

GO:0000723

telomere maintenance

IMP: Inferred from Mutant Phenotype

P

Source: GeneDB_Spombe

GO:0000077

DNA damage checkpoint

GO_REF:0000001

NAS: Non-traceable Author Statement

P

GO:0000166

nucleotide binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

GO:0000723

telomere maintenance

PMID:12196391[1]

IMP: Inferred from Mutant Phenotype

P

GO:0000781

chromosome, telomeric region

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0779

C

GO:0000781

chromosome, telomeric region

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0276

C

GO:0004672

protein kinase activity

PMID:10430579[2]

TAS: Traceable Author Statement

F

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015519

F

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR021668

F

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0723

F

GO:0005515

protein binding

PMID:15964794[3]

IPI: Inferred from Physical Interaction

GeneDB_Spombe:SPBC6B1.09c

F

GO:0005524

ATP binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

GO:0005694

chromosome

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0158

C

GO:0005829

cytosol

PMID:16823372[4]

IDA: Inferred from Direct Assay

C

GO:0006281

DNA repair

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0234

P

GO:0006468

protein phosphorylation

PMID:10430579[2]

TAS: Traceable Author Statement

P

GO:0006974

response to DNA damage stimulus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0227

P

GO:0016301

kinase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0418

F

GO:0016310

phosphorylation

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0418

P

GO:0016568

chromatin modification

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0156

P

GO:0016572

histone phosphorylation

PMID:15964794[3]

IGI: Inferred from Genetic Interaction

GeneDB_Spombe:SPCC23B6.03c

P

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

GO:0016772

transferase activity, transferring phosphorus-containing groups

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011009

F

GO:0016773

phosphotransferase activity, alcohol group as acceptor

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000403

F

GO:0016773

phosphotransferase activity, alcohol group as acceptor

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018936

F

GO:0018107

peptidyl-threonine phosphorylation

PMID:22302936[5]

IMP: Inferred from Mutant Phenotype

P

Figure 2 show that Tel 1 is required for phosphorylation of Thr 93 of Ccq1. Mutants without Tel 1 were unable to phosphorylate Ccq1.

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Nakamura TM et al. (2002) Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics 161: 1437-52 PubMed GONUTS page
  2. 2.0 2.1 Matsuura A et al. (1999) Genetic control of telomere integrity in Schizosaccharomyces pombe: rad3(+) and tel1(+) are parts of two regulatory networks independent of the downstream protein kinases chk1(+) and cds1(+). Genetics 152: 1501-12 PubMed GONUTS page
  3. 3.0 3.1 You Z et al. (2005) ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol 25: 5363-79 PubMed GONUTS page
  4. Matsuyama A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat Biotechnol 24: 841-7 PubMed GONUTS page
  5. Yamazaki H et al. (2012) Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast. Genes Dev 26: 241-6 PubMed GONUTS page
Personal tools
Namespaces
Variants
Actions
Navigation
Cacao
Journal Clubs
page contributors
Toolbox