SALTY:SOPE

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0344	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005515	protein binding	PMID:12093730^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P60953	F
	GO:0031532	actin cytoskeleton reorganization	PMID:9630225^[2]	IDA: Inferred from Direct Assay		P	Figure 1. SopE Induces Membrane Ruffling and Cytoskeletal Rearrangement. When a vector containing SopE is added to cells, the cytoskeleton changes its organization as seen through microscopy.	complete
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005414	C
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016019	C
	GO:0005096	GTPase activator activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0343	F
	GO:0009405	pathogenesis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0843	P
	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016019	F
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0032862	activation of Rho GTPase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016019	P
	GO:0009405	pathogenesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005414	P
	GO:0009405	pathogenesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016019	P
	GO:0032862	activation of Rho GTPase activity	PMID:9630225^[2]	IDA: Inferred from Direct Assay		P	Figure 7. SopE Stimulates Nucleotide Exchange in Several Rho GTPases In Vitro. When SopE is added to a solution of Rho GTPases, the activity of the GTPase increases, as proven by the increase in number of bound GTP over 45 minutes.	complete
	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005414	P
	GO:0007256	activation of JNKK activity	PMID:9630225^[2]	IDA: Inferred from Direct Assay		P	Figure 2. SopE Induces JNK Activation. A vector containing JNK and a vector containing SopE were inserted into COS-1 cells and activities were measured in an immunocomplex kinase assay. The increased activity of JNK in the presence of SopE was seen using immunoblot analyses.	complete
	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005414	F
	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005414	F
	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016019	F
	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0344	F
	GO:0005096	GTPase activator activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0343	F
	GO:0005515	protein binding	PMID:12093730^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P60953	F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005414	C
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016019	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0009405	pathogenesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005414	P
	GO:0009405	pathogenesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016019	P
	GO:0009405	pathogenesis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0843	P
	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005414	P
	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016019	P
	GO:0032862	activation of Rho GTPase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005414	P
	GO:0032862	activation of Rho GTPase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016019	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Buchwald G et al. (2002) Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO J 21: 3286-95 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Hardt WD et al. (1998) S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. Cell 93: 815-26 PubMed GONUTS page

[PMID:12093730-0] 1.0 ^1.1 Buchwald G et al. (2002) Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO J 21: 3286-95 PubMed GONUTS page

[PMID:9630225-1] 2.0 ^2.1 ^2.2 Hardt WD et al. (1998) S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. Cell 93: 815-26 PubMed GONUTS page

[1]

[2]

Species (Taxon ID)	Salmonella typhimurium. (taxon:90371)
Gene Name(s)	sopE
Protein Name(s)	Guanine nucleotide exchange factor sopE Effector protein sopE Toxin sopE
External Links
UniProt Identifier	SOPE_SALTY
UniProt Accessions	O52623,
EMBL	AF043239,
PDB	1GZS,
IntAct	O52623,
Pfam	PF05364, PF07487,

SALTY:SOPE

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