RefGenome Electronic Jamboree 2008-10 PFKL

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Orthoset

Participants

Name	Group	Organism(s)/Genome(s)	Notes
Susan Tweedie	flyBase	D. melanogaster	FBgn0003071
Kimberly Van Auken	WormBase	C. elegans	Working on PFKL ortholog C50F4.2 = WBGene00008230
Rachael Huntley	GOA	Human	UniProtKB: P17858
Emily Dimmer	GOA	Human	UniProtKB:P17858
Ruth Lovering	BHF-UCL	Human	UniProtKB:P17858
Varsha Khodiyar	BHF-UCL	Human	UniProtKB:P17858
Ranjana Kishore	WormBase	C. elegans	Worked on PKFL ortholog Y71H10A.1=WBGene00022199
Petra Fey	dictyBase	D. discoideum	DDB_G0274111
Eurie Hong	SGD	S. cerevisiae	SGD:S000003472 (PFK1); SGD:S000004818 (PFK2)
Debby Siegele	ecoliwiki	E. coli	UniProt:P0A796
Brenley McIntosh	ecoliwiki	E. coli	UniProt:P0A796
Jim Hu	ecoliwiki	E. coli	UniProt:P0A796 general wiki maintenance
Tanya Berardini	TAIR	A. thaliana	Arabidopsis PFKL genes, no NEDD4 gene
Li Ni	MGI	Mouse	UniProtKB:P12382
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PFKL

Category	ID	Term	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	Ecoli
Biological Process	GO:0040018	positive regulation of multicellular organism growth	X	X	X	X	X	X	IMP	X	X	X	X	X
Biological Process	GO:0006096	glycolysis	IDA	IDA	X	X	X	IC	X	X	IDA ISS	IMP IDA	X	IDA
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	IDA IMP	X	X	X	X	IMP	X	IDA	X	X	X	X
Biological Process	GO:0031115	negative regulation of microtubule polymerization	X	X	X	X	X	X	X	IDA	X	X	X	X
Biological Process	GO:0006007	glucose catabolic process	X	X	X	X	X	X	X	IGI	X	X	X	IMP
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	X	X	X	X	X	X	IMP	X	X	X	X	X
Biological Process	GO:0000003	reproduction	X	X	X	X	X	X	IMP	X	X	X	X	X
Biological Process	GO:0044275	cellular carbohydrate catabolic process	X	X	X	X	X	X	X	X	X	X	X	IMP
Biological Process	GO:0016052	carbohydrate catabolic process	X	X	X	X	X	X	X	X	X	X	X	IMP
Biological Process	GO:0046676	negative regulation of insulin secretion	X	IDA	X	X	X	X	X	X	X	X	X	X
Biological Process	GO:0009749	response to glucose stimulus	X	IDA	X	X	X	X	X	X	X	X	X	X
Molecular Function	GO:0003872	6-phosphofructokinase activity	IDA IMP	IDA	X	X	X	IMP	X	IDA IGI	IDA ISS	IMP	X	IMP
Molecular Function	GO:0015631	tubulin binding	X	X	X	X	X	X	X	IPI	X	X	X	X
Molecular Function	GO:0005524	ATP binding	IDA	X	X	X	X	X	X	X	X	X	X	IMP
Molecular Function	GO:0042802	identical protein binding	IPI	X	X	X	X	X	X	X	X	X	X	IDA
Molecular Function	GO:0005515	protein binding	IPI	X	X	X	X	X	X	X	X	X	X	X
Molecular Function	GO:0070061	fructose binding	IDA IC	X	X	X	X	X	X	X	X	X	X	X
Molecular Function	GO:0005488	binding	X	X	X	X	X	X	X	X	X	X	X	IDA
Molecular Function	GO:0000287	magnesium ion binding	X	X	X	X	X	X	X	X	X	X	X	IDA
Molecular Function	GO:0032553	ribonucleotide binding	X	X	X	X	X	X	X	X	X	X	X	IDA
Molecular Function	GO:0043531	ADP binding	X	X	X	X	X	X	X	X	X	X	X	IDA
Cellular Component	GO:0005945	6-phosphofructokinase complex	IDA	X	X	X	X	IC	X	IDA	X	IMP	X	IDA
Cellular Component	GO:0005829	cytosol	IDA	IDA	X	X	X	X	X	IDA	IDA	X	X	X
Cellular Component	GO:0005737	cytoplasm	X	X	X	X	X	X	X	X	X	X	X	IDA
Cellular Component	GO:0005886	plasma membrane	X	X	X	X	X	X	X	X	IDA	X	X	X
Cellular Component	GO:0009507	chloroplast	X	X	X	X	X	X	X	X	IDA	X	X	X

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Group	Organism	gene	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
WormBase	C.elegans	PFKL = C50F4.2 = WBGene0008230	GO:0040018	positive regulation of multicellular organism growth	PMID:11231151^[1]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00002413	P	This annotation is from a large-scale, high-throughput RNAi screen.	complete
FlyBase	Drosophila	FBgn0003071	GO:0003872	6-phosphofructokinase activity	PMID:7929140^[2]	IMP: Inferred from Mutant Phenotype		F		complete
FlyBase	Drosophila	FBgn0003071	GO:0005945	6-phosphofructokinase complex	PMID:7929140^[2]	IC: Inferred by Curator	GO:0003872	C		complete
FlyBase	Drosophila	FBgn0003071	GO:0006096	glycolysis	PMID:7929140^[2]	IC: Inferred by Curator	GO:0003872	P		complete
DictyBase	Dicty	DDB_G0274111	GO:0003872	6-phosphofructokinase activity	PMID:4300706^[3] PMID:7813455^[4]	IDA: Inferred from Direct Assay		F	purified enzyme	complete
DictyBase	Dicty	DDB_G0274111	GO:0003872	6-phosphofructokinase activity	PMID:7589492^[5]	IGI: Inferred from Genetic Interaction	S000003472\|S000004818	F	the Dicty recombinant protein expressed in the yeast mutant; yeast has 2 subunits, while Dicty has only one	complete
DictyBase	Dicty	DDB_G0274111	GO:0015631	tubulin binding	PMID:10026266^[6]	IPI: Inferred from Physical Interaction	P81948	F		complete
DictyBase	Dicty	DDB_G0274111	GO:0006002	fructose 6-phosphate metabolic process	PMID:7813455^[4]	IDA: Inferred from Direct Assay		P		complete
DictyBase	Dicty	DDB_G0274111	GO:0031115	negative regulation of microtubule polymerization	PMID:10026266^[6]	IDA: Inferred from Direct Assay		P		complete
DictyBase	Dicty	DDB_G0274111	GO:0006007	glucose catabolic process	PMID:7589492^[5]	IGI: Inferred from Genetic Interaction	S000003472\|S000004818	P	recombinant Dicty PfkA rescued the glucose growth defect in yeast mutants	complete
DictyBase	Dicty	DDB_G0274111	GO:0005829	cytosol	PMID:7813455^[4]	IDA: Inferred from Direct Assay		C		complete
DictyBase	Dicty	DDB_G0274111	GO:0005945	6-phosphofructokinase complex	PMID:7813455^[4]	IDA: Inferred from Direct Assay		C	gelfiltration, authors conclude it's a homotetramer	complete
GOA	Human	P17858	GO:0006002	fructose 6-phosphate metabolic process	PMID:6444721^[7]	IDA: Inferred from Direct Assay		P		complete
GOA	Human	P17858	GO:0006002	fructose 6-phosphate metabolic process	PMID:6227635^[8]	IMP: Inferred from Mutant Phenotype		P		complete
GOA	Human	P17858	GO:0006096	glycolysis	PMID:6444532^[9]	IDA:Inferred from Direct Assay		P		complete
GOA	Human	P17858	GO:0006096	glycolysis	PMID:6227635^[8]	IDA:Inferred from Direct Assay		P		complete
GOA	Human	P17858	GO:0003872	6-phosphofructokinase activity	PMID:6444721^[7]	IDA:Inferred from Direct Assay		F		complete
GOA	Human	P17858	GO:0003872	6-phosphofructokinase activity	PMID:6227635^[8]	IMP:Inferred from Mutant Phenotype		F		complete
GOA	Human	P17858	GO:0003872	6-phosphofructokinase activity	PMID:8780720^[10]	IDA:Inferred from Direct Assay		F		complete
GOA	Human	P17858	GO:0005524	ATP binding	PMID:8780720^[10]	IDA:Inferred from Direct Assay		F		complete
GOA	Human	P17858	GO:0005945	6-phosphofructokinase complex	PMID:6444721^[7]	IDA:Inferred from Direct Assay		C		complete
GOA	Human	P17858	GO:0005829	cytosol	PMID:16780588^[11]	IDA:Inferred from Direct Assay		C		complete
BHF-UCL	Human	P17858	GO:0042802	identical protein binding	PMID:6444721^[7]	IPI: Inferred from Physical Interaction	P17858	F		complete
BHF-UCL	Human	P17858	GO:0005515	protein binding	PMID:6444721^[7]	IPI: Inferred from Physical Interaction	P08237	F		complete
BHF-UCL	Human	P17858	GO:0070061	fructose binding	PMID:8780720^[10]	IDA: Inferred from Direct Assay		F		complete
BHF-UCL	Human	P17858	GO:0070061	fructose binding	PMID:6444721^[7]	IC: Inferred by Curator	GO:0003872	F		complete
WormBase	C.elegans	WBGene00022199	GO:0009792	embryonic development ending in birth or egg hatching	PMID:15791247^[12]	IMP: Inferred from Mutant Phenotype	WBRNAi00058226	P	This annotation is from a large-scale, high-throughput RNAi screen.	complete
BHF-UCL	Human	P17858	GO:0005515	protein binding	PMID:6444721^[7]	IPI: Inferred from Physical Interaction	P08237	F		complete
WormBase	C.elegans	WBGene00022199	GO:0009792	embryonic development ending in birth or egg hatching	PMID:11231151^[1]	IMP: Inferred from Mutant Phenotype	WBRNAi00001724	P	This annotation is from a large-scale, high-throughput RNAi screen.	complete
WormBase	C.elegans	PFKL = C50F4.2 = WBGene0008230	GO:0000003	reproduction	PMID:11231151^[1]	IMP: Inferred from Mutant Phenotype	WB:WBRNAi00002413	P	This annotation is from a large-scale, high-throughput RNAi screen.	complete
EcoliWiki	E. coli	UniProt:P0A796	GO:0003872	6-phosphofructokinase activity	PMID:125265^[13]	IMP: Inferred from Mutant Phenotype		F		complete
EcoliWiki	E. coli	UniProt:P0A796	GO:0005488	binding	PMID:17307338^[14]	IDA: Inferred from Direct Assay	CHEBI:18021	F	Phosphoenolpyruvate binding is inhibitory to phosphofructokinase activity.	complete
EcoliWiki	E. coli	UniProt:P0A796	GO:0005524	ATP binding	PMID:8202475^[15]	IMP: Inferred from Mutant Phenotype		F		complete
EcoliWiki	E. coli	UniProt:P0A796	GO:0000287	magnesium ion binding	PMID:1445885^[16]	IDA: Inferred from Direct Assay		F		complete
EcoliWiki	E. coli	UniProt:P0A796	GO:0005945	6-phosphofructokinase complex	PMID:6232272^[17]	IDA: Inferred from Direct Assay		C	The E. coli enzyme is a homotetramer	complete
EcoliWiki	E. coli	UniProt:P0A796	GO:0032553	ribonucleotide binding	PMID:4229913^[18]	IDA: Inferred from Direct Assay		F		complete
EcoliWiki	E. coli	UniProt:P0A796	GO:0005737	cytoplasm	PMID:4229913^[18]	IDA: Inferred from Direct Assay		C		complete
EcoliWiki	E. coli	UniProt:P0A796	GO:0042802	identical protein binding	PMID:11946283^[19]	IDA: Inferred from Direct Assay		F		complete
EcoliWiki	E. coli	UniProt:P0A796	GO:0044275	cellular carbohydrate catabolic process	PMID:4299078^[20]	IMP: Inferred from Mutant Phenotype		P	pfkA mutants are defective in utilization of glucose and mannitol.	complete
SGD	S. cerevisiae	SGD:S000003472 (PFK1)	GO:0003872	6-phosphofructokinase activity	PMID:3007939^[21]	IMP: Inferred from Mutant Phenotype		F		complete
EcoliWiki	E. coli	UniProt:P0A796	GO:0016052	carbohydrate catabolic process	PMID:4299078^[20]	IMP: Inferred from Mutant Phenotype		P	Seeded from EcoCyc 11.1^[22]. pfk mutants are defective for growth on glucose and mannitol.	complete
SGD	S. cerevisiae	SGD:S000004818 (PFK2)	GO:0003872	6-phosphofructokinase activity	PMID:3007939^[21]	IMP: Inferred from Mutant Phenotype		F		complete
SGD	S. cerevisiae	SGD:S000004818 (PFK2)	GO:0006096	glycolysis	PMID:3007939^[21]	IMP: Inferred from Mutant Phenotype		P		complete
SGD	S. cerevisiae	SGD:S000003472 (PFK1)	GO:0006096	glycolysis	PMID:3007939^[21]	IMP: Inferred from Mutant Phenotype		P		complete
SGD	S. cerevisiae	SGD:S000003472 (PFK1)	GO:0006096	glycolysis	PMID:3000145^[23]	IDA: Inferred from Direct Assay		P		complete
SGD	S. cerevisiae	SGD:S000004818 (PFK2)	GO:0006096	glycolysis	PMID:3000145^[23]	IDA: Inferred from Direct Assay		P		complete
SGD	S. cerevisiae	SGD:S000004818 (PFK2)	GO:0005945	6-phosphofructokinase complex	PMID:3007939^[21]	IMP: Inferred from Mutant Phenotype		C		complete
SGD	S. cerevisiae	SGD:S000003472 (PFK1)	GO:0005945	6-phosphofructokinase complex	PMID:3007939^[21]	IMP: Inferred from Mutant Phenotype		C		complete
TAIR	A. thaliana	PFK1 = AT4G29220	GO:0003872	6-phosphofructokinase activity	PMID:17485088^[24]	IDA		F		complete
TAIR	A. thaliana	PFK1 = AT4G29220	GO:0006096	glycolysis	PMID:17485088^[24]	IDA		P		complete
TAIR	A. thaliana	PFK1 = AT4G29220	GO:0005886	plasma membrane	PMID:17485088^[24]	IDA		C		complete
TAIR	A. thaliana	PFK1 = AT4G29220	GO:0005829	cytosol	PMID:17485088^[24]	IDA		C		complete
TAIR	A. thaliana	PFK4 = AT5G61580	GO:0003872	6-phosphofructokinase activity	PMID:17485088^[24]	IDA		F		complete
TAIR	A. thaliana	PFK4 = AT5G61580	GO:0006096	glycolysis	PMID:17485088^[24]	IDA		P		complete
TAIR	A. thaliana	PFK4 = AT5G61580	GO:0009507	chloroplast	PMID:17485088^[24]	IDA		C		complete
TAIR	A. thaliana	PFK2 = AT5G47810	GO:0003872	6-phosphofructokinase activity	PMID:17485088^[24]	ISS	AGI_LocusCode:AT4G29220	F		complete
TAIR	A. thaliana	PFK2 = AT5G47810	GO:0006096	glycolysis	PMID:17485088^[24]	ISS	AGI_LocusCode:AT4G29220	P		complete
TAIR	A. thaliana	PFK2 = AT5G47810	GO:0005829	cytosol	PMID:17485088^[24]	IDA		C		complete
EcoliWiki	E. coli	UniProt:P0A796	GO:0043531	ADP binding	PMID:11300795^[25]	IDA: Inferred from Direct Assay		F	ADP binds the allosteric site of E. coli PfkA	complete
EcoliWiki	E. coli	UniProt:P0A796	GO:0006096	glycolysis	PMID:15237399^[26]	IDA: Inferred from Direct Assay		P	Reconstitution	complete
FlyBase	Drosophila	FBgn0003071	GO:0006002	fructose 6-phosphate metabolic process	PMID:7929140^[2]	IMP: Inferred from Mutant Phenotype		P		complete
MGI	Mouse	Pfkl	GO:0003872	6-phosphofructokinase activity	PMID:8172601^[27] PMID:9287040^[28]	IDA: Inferred from Direct Assay		F		complete
MGI	Mouse	Pfkl	GO:0005829	cytosol	PMID:2521854^[29]	IDA: Inferred from Direct Assay		C		complete
MGI	Mouse	Pfkl	GO:0006096	glycolysis	PMID:8172601^[27] PMID:9287040^[28]	IDA: Inferred from Direct Assay		P		complete
MGI	Mouse	Pfkl	GO:0046676	negative regulation of insulin secretion	PMID:9287040^[28]	IDA: Inferred from Direct Assay		P		complete
MGI	Mouse	Pfkl	GO:0009749	response to glucose stimulus	PMID:9287040^[28]	IDA: Inferred from Direct Assay		P		complete
EcoliWiki	E. coli	UniProt:P0A796	GO:0006007	glucose catabolic process	PMID:4299078^[20]	IMP: Inferred from Mutant Phenotype		P		complete
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Notes

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Phosphofructokinase I at wikipedia.

The October 2008 electronic jamboree also annotated NEDD4

1. Inconsistency of annotations to Fructose 6-P metaoblism. Should all groups have annotated to this if there is an assay for PFK

2. inter-ontology link between F6P metabolism and PKF activity?

3. links between glycolysis and F6P metabolism possible?

4. Annotation to Glycolysis: when can you annotate this process with IDA/IMP to PFKL?

5. EcoliWiki couldn't find GO terms to indicate that the activity PfkA is allosterically regulated. We used GO:0005488 binding for binding of the allosteric effect phosphoenolpyruvate (PEP), which doesn't seem satisfactory. I don't think we need a term for PEP binding, though. I think a more general term for indicate allosteric regulation is what is needed.

6. Sorry for being dense, but what is the difference between GO:0016052 carbohydrate catabolic process and GO:0044275 cellular carbohydrate catabolic process?

References

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See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Maeda I et al. (2001) Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Curr Biol 11: 171-6 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Currie PD & Sullivan DT (1994) Structure and expression of the gene encoding phosphofructokinase (PFK) in Drosophila melanogaster. J Biol Chem 269: 24679-87 PubMed GONUTS page
↑ Baumann P & Wright BE (1968) The phosphofructokinase of Dictyostelium discoideum. Biochemistry 7: 3653-61 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Martínez-Costa OH et al. (1994) Purification and properties of phosphofructokinase from Dictyostelium discoideum. Eur J Biochem 226: 1007-17 PubMed GONUTS page
↑ ^5.0 ^5.1 Estévez AM et al. (1995) Functional complementation of yeast phosphofructokinase mutants by the non-allosteric enzyme from Dictyostelium discoideum. FEBS Lett 374: 100-4 PubMed GONUTS page
↑ ^6.0 ^6.1 Orosz F et al. (1999) Phosphofructokinase from Dictyostelium discoideum is a potent inhibitor of tubulin polymerization. Biochemistry 38: 1857-65 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Vora S et al. (1980) Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system. Proc Natl Acad Sci U S A 77: 62-6 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Vora S et al. (1983) Heterogeneity of the molecular lesions in inherited phosphofructokinase deficiency. J Clin Invest 72: 1995-2006 PubMed GONUTS page
↑ Vora S et al. (1980) The molecular mechanism of the inherited phosphofructokinase deficiency associated with hemolysis and myopathy. Blood 55: 629-35 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Durante P et al. (1996) Isozyme analysis of human polymorphonuclear leukocyte phosphofructokinase from insulin resistant individuals. Biochem Biophys Res Commun 225: 975-82 PubMed GONUTS page
↑ Hu YH et al. (2006) Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. BMC Genomics 7: 155 PubMed GONUTS page
↑ Sonnichsen B et al. (2005) Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature 434: 462-9 PubMed GONUTS page
↑ Vinopal RT et al. (1975) PfkA locus of Escherichia coli. J Bacteriol 122: 1162-71 PubMed GONUTS page
↑ Ogawa T et al. (2007) Inhibitory effect of phosphoenolpyruvate on glycolytic enzymes in Escherichia coli. Res Microbiol 158: 159-63 PubMed GONUTS page
↑ Auzat I et al. (1994) The cooperativity and allosteric inhibition of Escherichia coli phosphofructokinase depend on the interaction between threonine-125 and ATP. Proc Natl Acad Sci U S A 91: 5242-6 PubMed GONUTS page
↑ Johnson JL & Reinhart GD (1992) MgATP and fructose 6-phosphate interactions with phosphofructokinase from Escherichia coli. Biochemistry 31: 11510-8 PubMed GONUTS page
↑ Martel A & Garel JR (1984) Renaturation of the allosteric phosphofructokinase from Escherichia coli. J Biol Chem 259: 4917-21 PubMed GONUTS page
↑ ^18.0 ^18.1 Blangy D et al. (1968) Kinetics of the allosteric interactions of phosphofructokinase from Escherichia coli. J Mol Biol 31: 13-35 PubMed GONUTS page
↑ Blangy D (1968) Phosphofructokinase from E. Coli: Evidence for a tetrameric structure of the enzyme. FEBS Lett 2: 109-111 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Morrissey AT & Fraenkel DG (1968) Selection of fructose 6-phosphate kinase mutants in Escherichia coli. Biochem Biophys Res Commun 32: 467-73 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 Heinisch J (1986) Isolation and characterization of the two structural genes coding for phosphofructokinase in yeast. Mol Gen Genet 202: 75-82 PubMed GONUTS page
↑
↑ ^23.0 ^23.1 Hofmann E et al. (1985) Temporal organization of the phosphofructokinase/fructose-1,6-biphosphatase cycle. Adv Enzyme Regul 23: 331-62 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 ^24.6 ^24.7 ^24.8 ^24.9 Mustroph A et al. (2007) Characterisation of the ATP-dependent phosphofructokinase gene family from Arabidopsis thaliana. FEBS Lett 581: 2401-10 PubMed GONUTS page
↑ Pham AS et al. (2001) Persistent binding of MgADP to the E187A mutant of Escherichia coli phosphofructokinase in the absence of allosteric effects. Biochemistry 40: 4140-9 PubMed GONUTS page
↑ Itoh A et al. (2004) Application of capillary electrophoresis-mass spectrometry to synthetic in vitro glycolysis studies. Electrophoresis 25: 1996-2002 PubMed GONUTS page
↑ ^27.0 ^27.1 Elson A et al. (1994) Overexpression of liver-type phosphofructokinase (PFKL) in transgenic-PFKL mice: implication for gene dosage in trisomy 21. Biochem J 299 ( Pt 2): 409-15 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 Knobler H et al. (1997) Impaired glucose-induced insulin response in transgenic mice overexpressing the L-phosphofructokinase gene. Diabetes 46: 1414-8 PubMed GONUTS page
↑ Gekakis N et al. (1989) Phosphofructokinase isozyme expression during myoblast differentiation. J Biol Chem 264: 3658-61 PubMed GONUTS page

[PMID:11231151-0] 1.0 ^1.1 ^1.2 Maeda I et al. (2001) Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Curr Biol 11: 171-6 PubMed GONUTS page

[PMID:7929140-1] 2.0 ^2.1 ^2.2 ^2.3 Currie PD & Sullivan DT (1994) Structure and expression of the gene encoding phosphofructokinase (PFK) in Drosophila melanogaster. J Biol Chem 269: 24679-87 PubMed GONUTS page

[PMID:4300706-2] Baumann P & Wright BE (1968) The phosphofructokinase of Dictyostelium discoideum. Biochemistry 7: 3653-61 PubMed GONUTS page

[PMID:7813455-3] 4.0 ^4.1 ^4.2 ^4.3 Martínez-Costa OH et al. (1994) Purification and properties of phosphofructokinase from Dictyostelium discoideum. Eur J Biochem 226: 1007-17 PubMed GONUTS page

[PMID:7589492-4] 5.0 ^5.1 Estévez AM et al. (1995) Functional complementation of yeast phosphofructokinase mutants by the non-allosteric enzyme from Dictyostelium discoideum. FEBS Lett 374: 100-4 PubMed GONUTS page

[PMID:10026266-5] 6.0 ^6.1 Orosz F et al. (1999) Phosphofructokinase from Dictyostelium discoideum is a potent inhibitor of tubulin polymerization. Biochemistry 38: 1857-65 PubMed GONUTS page

[PMID:6444721-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Vora S et al. (1980) Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system. Proc Natl Acad Sci U S A 77: 62-6 PubMed GONUTS page

[PMID:6227635-7] 8.0 ^8.1 ^8.2 Vora S et al. (1983) Heterogeneity of the molecular lesions in inherited phosphofructokinase deficiency. J Clin Invest 72: 1995-2006 PubMed GONUTS page

[PMID:6444532-8] Vora S et al. (1980) The molecular mechanism of the inherited phosphofructokinase deficiency associated with hemolysis and myopathy. Blood 55: 629-35 PubMed GONUTS page

[PMID:8780720-9] 10.0 ^10.1 ^10.2 Durante P et al. (1996) Isozyme analysis of human polymorphonuclear leukocyte phosphofructokinase from insulin resistant individuals. Biochem Biophys Res Commun 225: 975-82 PubMed GONUTS page

[PMID:16780588-10] Hu YH et al. (2006) Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. BMC Genomics 7: 155 PubMed GONUTS page

[PMID:15791247-11] Sonnichsen B et al. (2005) Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature 434: 462-9 PubMed GONUTS page

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[LIB:EcoCyc11.1-21] ↑

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[PMID:17485088-23] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 ^24.6 ^24.7 ^24.8 ^24.9 Mustroph A et al. (2007) Characterisation of the ATP-dependent phosphofructokinase gene family from Arabidopsis thaliana. FEBS Lett 581: 2401-10 PubMed GONUTS page

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RefGenome Electronic Jamboree 2008-10 PFKL

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