RAT:TRUA

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Species (Taxon ID)	Rattus norvegicus (Rat). (taxon:10116)
Gene Name(s)	Pus1
Protein Name(s)	tRNA pseudouridine synthase A, mitochondrial tRNA pseudouridine(38-40) synthase tRNA pseudouridylate synthase I tRNA-uridine isomerase I
External Links
UniProt Identifier	TRUA_RAT
UniProt Accessions	Q4KM92,
EMBL	AC095390,
RefSeq	NP_001020734.1,
Ensembl	ENSRNOT00000056780,
Pfam	PF01416,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0001522	pseudouridine synthesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001406	P
	GO:0001522	pseudouridine synthesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020094	P
	GO:0001522	pseudouridine synthesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020095	P
	GO:0001522	pseudouridine synthesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020097	P
	GO:0001522	pseudouridine synthesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020103	P
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001406	F
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020094	F
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020095	F
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020097	F
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020103	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005739	mitochondrion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0496	C
	GO:0005739	mitochondrion	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0173	C
	GO:0008033	tRNA processing	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0819	P
	GO:0009451	RNA modification	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001406	P
	GO:0009451	RNA modification	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020094	P
	GO:0009451	RNA modification	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020095	P
	GO:0009451	RNA modification	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020097	P
	GO:0009451	RNA modification	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020103	P
	GO:0009982	pseudouridine synthase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001406	F
	GO:0009982	pseudouridine synthase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020094	F
	GO:0009982	pseudouridine synthase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020095	F
	GO:0009982	pseudouridine synthase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020097	F
	GO:0009982	pseudouridine synthase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020103	F
	GO:0009982	pseudouridine synthase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:5.4.99.12	F
	GO:0016853	isomerase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0413	F
	GO:0008033	tRNA processing	PMID:10492022^[1]	IDA: Inferred from Direct Assay		P	Figures 2 and 3	complete
	GO:0001522	pseudouridine synthesis	PMID:18648068^[2]	IMP: Inferred from Mutant Phenotype		P	Figure 3	complete
	GO:0009982	pseudouridine synthase activity	PMID:18648068^[2]	IMP: Inferred from Mutant Phenotype		F	Figure 3	complete
	GO:0005739	mitochondrion	PMID:15772074^[3]	IDA: Inferred from Direct Assay		C	Figure 5	complete
	GO:0001522	pseudouridine synthesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001406	P
	GO:0001522	pseudouridine synthesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020094	P
	GO:0001522	pseudouridine synthesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020095	P
	GO:0001522	pseudouridine synthesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020097	P
	GO:0001522	pseudouridine synthesis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020103	P
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001406	F
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020094	F
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020095	F
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020097	F
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020103	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005739	mitochondrion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0496	C
	GO:0005739	mitochondrion	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0173	C
	GO:0008033	tRNA processing	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0819	P
	GO:0009451	RNA modification	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001406	P
	GO:0009451	RNA modification	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020094	P
	GO:0009451	RNA modification	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020095	P
	GO:0009451	RNA modification	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020097	P
	GO:0009451	RNA modification	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020103	P
	GO:0009982	pseudouridine synthase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001406	F
	GO:0009982	pseudouridine synthase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020094	F
	GO:0009982	pseudouridine synthase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020095	F
	GO:0009982	pseudouridine synthase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020097	F
	GO:0009982	pseudouridine synthase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020103	F
	GO:0009982	pseudouridine synthase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:5.4.99.12	F
	GO:0016853	isomerase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0413	F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Arluison V et al. (1999) RNA:pseudouridine synthetase Pus1 from Saccharomyces cerevisiae: oligomerization property and stoichiometry of the complex with yeast tRNA(Phe). Biochimie 81: 751-6 PubMed GONUTS page
↑ ^2.0 ^2.1 Sibert BS et al. (2008) Partial activity is seen with many substitutions of highly conserved active site residues in human Pseudouridine synthase 1. RNA 14: 1895-906 PubMed GONUTS page
↑ Patton JR et al. (2005) Mitochondrial myopathy and sideroblastic anemia (MLASA): missense mutation in the pseudouridine synthase 1 (PUS1) gene is associated with the loss of tRNA pseudouridylation. J Biol Chem 280: 19823-8 PubMed GONUTS page

[PMID:10492022-0] Arluison V et al. (1999) RNA:pseudouridine synthetase Pus1 from Saccharomyces cerevisiae: oligomerization property and stoichiometry of the complex with yeast tRNA(Phe). Biochimie 81: 751-6 PubMed GONUTS page

[PMID:18648068-1] 2.0 ^2.1 Sibert BS et al. (2008) Partial activity is seen with many substitutions of highly conserved active site residues in human Pseudouridine synthase 1. RNA 14: 1895-906 PubMed GONUTS page

[PMID:15772074-2] Patton JR et al. (2005) Mitochondrial myopathy and sideroblastic anemia (MLASA): missense mutation in the pseudouridine synthase 1 (PUS1) gene is associated with the loss of tRNA pseudouridylation. J Biol Chem 280: 19823-8 PubMed GONUTS page

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RAT:TRUA

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