RAT:TRPV4

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Species (Taxon ID)	Rattus norvegicus (Rat). (taxon:10116)
Gene Name(s)	Trpv4 ( synonyms: Vroac )
Protein Name(s)	Transient receptor potential cation channel subfamily V member 4 TrpV4 Osm-9-like TRP channel 4 OTRPC4 Vanilloid receptor-related osmotically-activated channel VR-OAC
External Links
UniProt Identifier	TRPV4_RAT
UniProt Accessions	Q9ERZ8,
EMBL	AF263521,
RefSeq	NP_076460.1,
Ensembl	ENSRNOT00000001586,
Pfam	PF00023, PF00520,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0003779	actin binding	PMID:20657843^[1]	IDA: Inferred from Direct Assay		F
	GO:0005034	osmosensor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	F
	GO:0005080	protein kinase C binding	PMID:20657843^[1]	IDA: Inferred from Direct Assay		F
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	F
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	F
	GO:0005216	ion channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0407	F
	GO:0005261	cation channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	F
	GO:0005261	cation channel activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	F
	GO:0005261	cation channel activity	PMID:11081638^[2]	IDA: Inferred from Direct Assay		F
	GO:0005262	calcium channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0107	F
	GO:0005262	calcium channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	F
	GO:0005262	calcium channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	F
	GO:0005262	calcium channel activity	PMID:20657843^[1]	IDA: Inferred from Direct Assay		F
	GO:0005516	calmodulin binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0112	F
	GO:0005516	calmodulin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	F
	GO:0005516	calmodulin binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	F
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	C
	GO:0005886	plasma membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	C
	GO:0005912	adherens junction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	C
	GO:0005912	adherens junction	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0009	C
	GO:0005912	adherens junction	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	C
	GO:0005925	focal adhesion	PMID:20657843^[1]	IDA: Inferred from Direct Assay		C
	GO:0005929	cilium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	C
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	P
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	P
	GO:0006811	ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0406	P
	GO:0006816	calcium ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0109	P
	GO:0006816	calcium ion transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	P
	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	P
	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	P
	GO:0006970	response to osmotic stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0006971	hypotonic response	PMID:11081638^[2]	IDA: Inferred from Direct Assay		P
	GO:0007015	actin filament organization	PMID:20657843^[1]	IDA: Inferred from Direct Assay		P
	GO:0007043	cell-cell junction assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0007043	cell-cell junction assembly	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	P
	GO:0007204	elevation of cytosolic calcium ion concentration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	P
	GO:0007231	osmosensory signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0008017	microtubule binding	PMID:20657843^[1]	IDA: Inferred from Direct Assay		F
	GO:0010977	negative regulation of neuron projection development	PMID:20657843^[1]	IDA: Inferred from Direct Assay		P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0030027	lamellipodium	PMID:20657843^[1]	IDA: Inferred from Direct Assay		C
	GO:0030054	cell junction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0965	C
	GO:0030103	vasopressin secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0030175	filopodium	PMID:20657843^[1]	IDA: Inferred from Direct Assay		C
	GO:0030426	growth cone	PMID:20657843^[1]	IDA: Inferred from Direct Assay		C
	GO:0030864	cortical actin cytoskeleton	PMID:20657843^[1]	IDA: Inferred from Direct Assay		C
	GO:0031117	positive regulation of microtubule depolymerization	PMID:20657843^[1]	IDA: Inferred from Direct Assay		P
	GO:0031532	actin cytoskeleton reorganization	PMID:20657843^[1]	IDA: Inferred from Direct Assay		P
	GO:0032587	ruffle membrane	PMID:20657843^[1]	IDA: Inferred from Direct Assay		C
	GO:0042538	hyperosmotic salinity response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0042802	identical protein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	F
	GO:0043014	alpha-tubulin binding	PMID:20657843^[1]	IDA: Inferred from Direct Assay		F
	GO:0043622	cortical microtubule organization	PMID:20657843^[1]	IDA: Inferred from Direct Assay		P
	GO:0046785	microtubule polymerization	PMID:20657843^[1]	IDA: Inferred from Direct Assay		P
	GO:0047484	regulation of response to osmotic stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0048487	beta-tubulin binding	PMID:20657843^[1]	IDA: Inferred from Direct Assay		F
	GO:0051015	actin filament binding	PMID:20657843^[1]	IDA: Inferred from Direct Assay		F
	GO:0055085	transmembrane transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	P
	GO:0070509	calcium ion import	PMID:20657843^[1]	IDA: Inferred from Direct Assay		P
	GO:0070588	calcium ion transmembrane transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0107	P
	GO:0005881	cytoplasmic microtubule	PMID:20657843^[1]	IDA: Inferred from Direct Assay		C
	GO:0003779	actin binding	PMID:20657843^[1]	IDA: Inferred from Direct Assay		F
	GO:0005034	osmosensor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	F
	GO:0005080	protein kinase C binding	PMID:20657843^[1]	IDA: Inferred from Direct Assay		F
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	F
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	F
	GO:0005216	ion channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0407	F
	GO:0005261	cation channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	F
	GO:0005261	cation channel activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	F
	GO:0005261	cation channel activity	PMID:11081638^[2]	IDA: Inferred from Direct Assay		F
	GO:0005262	calcium channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0107	F
	GO:0005262	calcium channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	F
	GO:0005262	calcium channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	F
	GO:0005262	calcium channel activity	PMID:20657843^[1]	IDA: Inferred from Direct Assay		F
	GO:0005516	calmodulin binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0112	F
	GO:0005516	calmodulin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	F
	GO:0005516	calmodulin binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	F
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	C
	GO:0005886	plasma membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	C
	GO:0005912	adherens junction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	C
	GO:0005912	adherens junction	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0009	C
	GO:0005912	adherens junction	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	C
	GO:0005925	focal adhesion	PMID:20657843^[1]	IDA: Inferred from Direct Assay		C
	GO:0005929	cilium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	C
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	P
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	P
	GO:0006811	ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0406	P
	GO:0006816	calcium ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0109	P
	GO:0006816	calcium ion transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	P
	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	P
	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	P
	GO:0006970	response to osmotic stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0006971	hypotonic response	PMID:11081638^[2]	IDA: Inferred from Direct Assay		P
	GO:0007015	actin filament organization	PMID:20657843^[1]	IDA: Inferred from Direct Assay		P
	GO:0007043	cell-cell junction assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0007043	cell-cell junction assembly	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EPK8	P
	GO:0007204	elevation of cytosolic calcium ion concentration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	P
	GO:0007231	osmosensory signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0008017	microtubule binding	PMID:20657843^[1]	IDA: Inferred from Direct Assay		F
	GO:0010977	negative regulation of neuron projection development	PMID:20657843^[1]	IDA: Inferred from Direct Assay		P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0019901	protein kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	F
	GO:0019901	protein kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	F
	GO:0030027	lamellipodium	PMID:20657843^[1]	IDA: Inferred from Direct Assay		C
	GO:0030054	cell junction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0965	C
	GO:0030103	vasopressin secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0030175	filopodium	PMID:20657843^[1]	IDA: Inferred from Direct Assay		C
	GO:0030426	growth cone	PMID:20657843^[1]	IDA: Inferred from Direct Assay		C
	GO:0030864	cortical actin cytoskeleton	PMID:20657843^[1]	IDA: Inferred from Direct Assay		C
	GO:0031117	positive regulation of microtubule depolymerization	PMID:20657843^[1]	IDA: Inferred from Direct Assay		P
	GO:0031532	actin cytoskeleton reorganization	PMID:20657843^[1]	IDA: Inferred from Direct Assay		P
	GO:0032587	ruffle membrane	PMID:20657843^[1]	IDA: Inferred from Direct Assay		C
	GO:0042169	SH2 domain binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	F
	GO:0042538	hyperosmotic salinity response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0043014	alpha-tubulin binding	PMID:20657843^[1]	IDA: Inferred from Direct Assay		F
	GO:0043622	cortical microtubule organization	PMID:20657843^[1]	IDA: Inferred from Direct Assay		P
	GO:0046785	microtubule polymerization	PMID:20657843^[1]	IDA: Inferred from Direct Assay		P
	GO:0047484	regulation of response to osmotic stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0048487	beta-tubulin binding	PMID:20657843^[1]	IDA: Inferred from Direct Assay		F
	GO:0051015	actin filament binding	PMID:20657843^[1]	IDA: Inferred from Direct Assay		F
	GO:0055085	transmembrane transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	P
	GO:0070509	calcium ion import	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
	GO:0070509	calcium ion import	PMID:20657843^[1]	IDA: Inferred from Direct Assay		P
	GO:0070588	calcium ion transmembrane transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0107	P
	GO:0070588	calcium ion transmembrane transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	P
	GO:0071476	cellular hypotonic response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071859	P
colocalizes_with	GO:0005881	cytoplasmic microtubule	PMID:20657843^[1]	IDA: Inferred from Direct Assay		C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 ^1.27 ^1.28 ^1.29 ^1.30 ^1.31 ^1.32 ^1.33 ^1.34 ^1.35 ^1.36 ^1.37 ^1.38 ^1.39 ^1.40 ^1.41 Goswami C et al. (2010) Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells. PLoS One 5: e11654 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Liedtke W et al. (2000) Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103: 525-35 PubMed GONUTS page

[PMID:20657843-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 ^1.27 ^1.28 ^1.29 ^1.30 ^1.31 ^1.32 ^1.33 ^1.34 ^1.35 ^1.36 ^1.37 ^1.38 ^1.39 ^1.40 ^1.41 Goswami C et al. (2010) Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells. PLoS One 5: e11654 PubMed GONUTS page

[PMID:11081638-1] 2.0 ^2.1 ^2.2 ^2.3 Liedtke W et al. (2000) Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103: 525-35 PubMed GONUTS page

[1]

[2]

RAT:TRPV4

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