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RAT:TRPA1

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Trpa1 (synonyms: Anktm1)
Protein Name(s) Transient receptor potential cation channel subfamily A member 1

Ankyrin-like with transmembrane domains protein 1

External Links
UniProt Q6RI86
EMBL AY496961
RefSeq NP_997491.1
UniGene Rn.105247
ProteinModelPortal Q6RI86
STRING 10116.ENSRNOP00000009874
BindingDB Q6RI86
ChEMBL CHEMBL5160
GuidetoPHARMACOLOGY 485
PaxDb Q6RI86
PRIDE Q6RI86
GeneID 312896
KEGG rno:312896
UCSC RGD:1303284
CTD 8989
RGD 1303284
eggNOG COG0666
HOGENOM HOG000044486
HOVERGEN HBG059027
InParanoid Q6RI86
KO K04984
PhylomeDB Q6RI86
NextBio 665335
PRO PR:Q6RI86
Proteomes UP000002494
Genevestigator Q6RI86
GO GO:0016021
GO:0006811
GO:0050896
Gene3D 1.25.40.20
InterPro IPR002110
IPR020683
IPR030288
PANTHER PTHR24190:SF5
Pfam PF00023
PF12796
PRINTS PR01415
SMART SM00248
SUPFAM SSF48403
PROSITE PS50297
PS50088

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75762

C

Seeded From UniProt

complete

enables

GO:0097604

temperature-gated cation channel activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75762

F

Seeded From UniProt

complete

enables

GO:0015278

calcium-release channel activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75762

F

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75762

P

Seeded From UniProt

complete

involved_in

GO:0051289

protein homotetramerization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75762

P

Seeded From UniProt

complete

involved_in

GO:0019233

sensory perception of pain

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75762

P

Seeded From UniProt

complete

involved_in

GO:0010033

response to organic substance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75762

P

Seeded From UniProt

complete

enables

GO:1990760

osmolarity-sensing cation channel activity

PMID:18279313[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1904058

positive regulation of sensory perception of pain

PMID:24120766[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903793

positive regulation of anion transport

PMID:22207576[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903522

regulation of blood circulation

PMID:22133672[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0098908

regulation of neuronal action potential

PMID:20205719[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097553

calcium ion transmembrane import into cytosol

PMID:14712238[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071313

cellular response to caffeine

PMID:22319196[7]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071244

cellular response to carbon dioxide

PMID:20881114[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070417

cellular response to cold

PMID:21068322[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035774

positive regulation of insulin secretion involved in cellular response to glucose stimulus

PMID:22701540[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034605

cellular response to heat

PMID:22458587[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:18514429[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:22207576[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0014832

urinary bladder smooth muscle contraction

PMID:21367919[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005245

voltage-gated calcium channel activity

PMID:14712238[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051209

release of sequestered calcium ion into cytosol

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015278

P

Seeded From UniProt

complete

enables

GO:0005216

ion channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821
InterPro:IPR030288

F

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030288

C

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030288

P

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

involved_in

GO:0050896

response to stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0716

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Zhang, XF et al. (2008) Transient receptor potential A1 mediates an osmotically activated ion channel. Eur. J. Neurosci. 27 605-11 PubMed GONUTS page
  2. ↑ Krimon, S et al. (2013) P2X3 receptors induced inflammatory nociception modulated by TRPA1, 5-HT3 and 5-HT1A receptors. Pharmacol. Biochem. Behav. 112 49-55 PubMed GONUTS page
  3. ↑ 3.0 3.1 Kaji, I et al. (2012) Activation of TRPA1 by luminal stimuli induces EP4-mediated anion secretion in human and rat colon. Am. J. Physiol. Gastrointest. Liver Physiol. 302 G690-701 PubMed GONUTS page
  4. ↑ Koivisto, A et al. (2012) Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy. Pharmacol. Res. 65 149-58 PubMed GONUTS page
  5. ↑ McGaraughty, S et al. (2010) TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Mol Pain 6 14 PubMed GONUTS page
  6. ↑ 6.0 6.1 Jordt, SE et al. (2004) Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427 260-5 PubMed GONUTS page
  7. ↑ Bianchi, BR et al. (2012) Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels. J. Pharmacol. Exp. Ther. 341 360-8 PubMed GONUTS page
  8. ↑ Wang, YY et al. (2010) TRPA1 is a component of the nociceptive response to CO2. J. Neurosci. 30 12958-63 PubMed GONUTS page
  9. ↑ del Camino, D et al. (2010) TRPA1 contributes to cold hypersensitivity. J. Neurosci. 30 15165-74 PubMed GONUTS page
  10. ↑ Cao, DS et al. (2012) Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. PLoS ONE 7 e38005 PubMed GONUTS page
  11. ↑ Wang, S et al. (2012) Warmth suppresses and desensitizes damage-sensing ion channel TRPA1. Mol Pain 8 22 PubMed GONUTS page
  12. ↑ Ji, G et al. (2008) Intact Adelta-fibers up-regulate transient receptor potential A1 and contribute to cold hypersensitivity in neuropathic rats. Neuroscience 154 1054-66 PubMed GONUTS page
  13. ↑ Andrade, EL et al. (2011) TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury. Am. J. Physiol. Renal Physiol. 300 F1223-34 PubMed GONUTS page
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