RAT:SHC1

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Species (Taxon ID)	Rattus norvegicus (Rat). (taxon:10116)
Gene Name(s)	Shc1
Protein Name(s)	SHC-transforming protein 1 Src homology 2 domain-containing-transforming protein C1 SH2 domain protein C1
External Links
UniProt Identifier	SHC1_RAT
UniProt Accessions	Q5M824,
EMBL	BC088298,
RefSeq	NP_445969.2,
Pfam	PF00640, PF00017,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005737	cytoplasm				C	Source: UniProtKB-KW
	GO:0005515	protein binding				F	Source: InterPro
	GO:0007242	intracellular signaling cascade				P	Source: InterPro
	GO:0001558	regulation of cell growth				P	Source: UniProtKB-KW
	GO:0000165	MAPKKK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000401303	P
	GO:0000187	activation of MAPK activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000091940	P
	GO:0000187	activation of MAPK activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000401303	P
	GO:0000187	activation of MAPK activity	PMID:15262993^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0001525	angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000091940	P
	GO:0001666	response to hypoxia	PMID:16439820^[2]	IEP: Inferred from Expression Pattern		P
	GO:0001784	phosphotyrosine binding	PMID:9271418^[3]	IPI: Inferred from Physical Interaction	RGD:2561	F
	GO:0005154	epidermal growth factor receptor binding	PMID:7513704^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9QX70	F
	GO:0005158	insulin receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000401303	F
	GO:0005159	insulin-like growth factor receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000401303	F
	GO:0005515	protein binding	PMID:12837289^[5]	IPI: Inferred from Physical Interaction	RGD:620795	F
	GO:0005515	protein binding	PMID:12933696^[6]	IPI: Inferred from Physical Interaction	RGD:68396	F
	GO:0005634	nucleus	PMID:15375560^[7]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:15375560^[7]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000401303	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000401303	C
	GO:0005886	plasma membrane	PMID:12837289^[5]	IDA: Inferred from Direct Assay		C
	GO:0007265	Ras protein signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000401303	P
	GO:0007507	heart development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000091940	P
	GO:0007568	aging	PMID:11954667^[8]	IPI: Inferred from Physical Interaction	RGD:619758	P
	GO:0008286	insulin receptor signaling pathway	PMID:17925406^[9]	IDA: Inferred from Direct Assay		P
	GO:0008286	insulin receptor signaling pathway	PMID:7513704^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0009636	response to toxin	PMID:16699171^[10]	IEP: Inferred from Expression Pattern		P
	GO:0010008	endosome membrane	PMID:17363458^[11]	IDA: Inferred from Direct Assay		C
	GO:0014070	response to organic cyclic compound	PMID:16699171^[10]	IEP: Inferred from Expression Pattern		P
	GO:0016337	cell-cell adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000091940	P
	GO:0030036	actin cytoskeleton organization	PMID:15262993^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0030182	neuron differentiation	PMID:17274988^[12]	IMP: Inferred from Mutant Phenotype		P
	GO:0031100	organ regeneration	PMID:15067377^[13]	IEP: Inferred from Expression Pattern		P
	GO:0031175	neuron projection development	PMID:15485499^[14]	IMP: Inferred from Mutant Phenotype		P
	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000091940	P
	GO:0032403	protein complex binding	PMID:17274988^[12]	IPI: Inferred from Physical Interaction	RGD:1353820	F
	GO:0032868	response to insulin stimulus	PMID:11954667^[8]	IEP: Inferred from Expression Pattern		P
	GO:0035094	response to nicotine	PMID:17068140^[15]	IEP: Inferred from Expression Pattern		P
	GO:0035556	intracellular signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006019	P
	GO:0040008	regulation of growth	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0341	P
	GO:0042542	response to hydrogen peroxide	PMID:16699171^[10]	IEP: Inferred from Expression Pattern		P
	GO:0045740	positive regulation of DNA replication	PMID:7513704^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0045907	positive regulation of vasoconstriction	PMID:16242150^[16]	IMP: Inferred from Mutant Phenotype		P
	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:12837289^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0051219	phosphoprotein binding	PMID:8910399^[17]	IPI: Inferred from Physical Interaction	RGD:2598	F
	GO:0051384	response to glucocorticoid stimulus	PMID:10612430^[18]	IEP: Inferred from Expression Pattern		P
	GO:0070435	Shc-EGFR complex	PMID:7513704^[4]	IDA: Inferred from Direct Assay		C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Natalicchio A et al. (2004) Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts. J Biol Chem 279: 43900-9 PubMed GONUTS page
↑ Bianchi G et al. (2006) p53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia. Gerontology 52: 17-23 PubMed GONUTS page
↑ Dankort DL et al. (1997) Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation. Mol Cell Biol 17: 5410-25 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Sasaoka T et al. (1994) Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. J Biol Chem 269: 13689-94 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Sayeski PP & Ali MS (2003) The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation. Exp Cell Res 287: 339-49 PubMed GONUTS page
↑ Sasaoka T et al. (2003) Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells. Endocrinology 144: 4204-14 PubMed GONUTS page
↑ ^7.0 ^7.1 Yoshida S et al. (2004) Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats. Int J Oncol 25: 1089-96 PubMed GONUTS page
↑ ^8.0 ^8.1 Fernandes ML et al. (2001) Effects of age on elements of insulin-signaling pathway in central nervous system of rats. Endocrine 16: 227-34 PubMed GONUTS page
↑ Jensen M et al. (2007) Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. J Biol Chem 282: 35179-86 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Obreztchikova M et al. (2006) Distinct signaling functions for Shc isoforms in the heart. J Biol Chem 281: 20197-204 PubMed GONUTS page
↑ Balbis A et al. (2007) Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes. Endocrinology 148: 2944-54 PubMed GONUTS page
↑ ^12.0 ^12.1 Degoutin J et al. (2007) ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation. FEBS Lett 581: 727-34 PubMed GONUTS page
↑ Yuji J et al. (2004) Identification of p46 Shc expressed in the nuclei of hepatocytes with high proliferating activity: Study of regenerating rat liver. Int J Mol Med 13: 721-8 PubMed GONUTS page
↑ Hinsby AM et al. (2004) ShcA regulates neurite outgrowth stimulated by neural cell adhesion molecule but not by fibroblast growth factor 2: evidence for a distinct fibroblast growth factor receptor response to neural cell adhesion molecule activation. J Neurochem 91: 694-703 PubMed GONUTS page
↑ Wada T et al. (2007) Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells. Endocrinology 148: 790-9 PubMed GONUTS page
↑ Yamamori T et al. (2005) P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction. J Mol Cell Cardiol 39: 992-5 PubMed GONUTS page
↑ Kimura T et al. (1996) Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor. J Biol Chem 271: 27962-8 PubMed GONUTS page
↑ Páez-Espinosa EV et al. (1999) Insulin-induced tyrosine phosphorylation of Shc in liver, muscle and adipose tissue of insulin resistant rats. Mol Cell Endocrinol 156: 121-9 PubMed GONUTS page

[PMID:15262993-0] 1.0 ^1.1 Natalicchio A et al. (2004) Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts. J Biol Chem 279: 43900-9 PubMed GONUTS page

[PMID:16439820-1] Bianchi G et al. (2006) p53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia. Gerontology 52: 17-23 PubMed GONUTS page

[PMID:9271418-2] Dankort DL et al. (1997) Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation. Mol Cell Biol 17: 5410-25 PubMed GONUTS page

[PMID:7513704-3] 4.0 ^4.1 ^4.2 ^4.3 Sasaoka T et al. (1994) Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. J Biol Chem 269: 13689-94 PubMed GONUTS page

[PMID:12837289-4] 5.0 ^5.1 ^5.2 Sayeski PP & Ali MS (2003) The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation. Exp Cell Res 287: 339-49 PubMed GONUTS page

[PMID:12933696-5] Sasaoka T et al. (2003) Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells. Endocrinology 144: 4204-14 PubMed GONUTS page

[PMID:15375560-6] 7.0 ^7.1 Yoshida S et al. (2004) Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats. Int J Oncol 25: 1089-96 PubMed GONUTS page

[PMID:11954667-7] 8.0 ^8.1 Fernandes ML et al. (2001) Effects of age on elements of insulin-signaling pathway in central nervous system of rats. Endocrine 16: 227-34 PubMed GONUTS page

[PMID:17925406-8] Jensen M et al. (2007) Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. J Biol Chem 282: 35179-86 PubMed GONUTS page

[PMID:16699171-9] 10.0 ^10.1 ^10.2 Obreztchikova M et al. (2006) Distinct signaling functions for Shc isoforms in the heart. J Biol Chem 281: 20197-204 PubMed GONUTS page

[PMID:17363458-10] Balbis A et al. (2007) Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes. Endocrinology 148: 2944-54 PubMed GONUTS page

[PMID:17274988-11] 12.0 ^12.1 Degoutin J et al. (2007) ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation. FEBS Lett 581: 727-34 PubMed GONUTS page

[PMID:15067377-12] Yuji J et al. (2004) Identification of p46 Shc expressed in the nuclei of hepatocytes with high proliferating activity: Study of regenerating rat liver. Int J Mol Med 13: 721-8 PubMed GONUTS page

[PMID:15485499-13] Hinsby AM et al. (2004) ShcA regulates neurite outgrowth stimulated by neural cell adhesion molecule but not by fibroblast growth factor 2: evidence for a distinct fibroblast growth factor receptor response to neural cell adhesion molecule activation. J Neurochem 91: 694-703 PubMed GONUTS page

[PMID:17068140-14] Wada T et al. (2007) Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells. Endocrinology 148: 790-9 PubMed GONUTS page

[PMID:16242150-15] Yamamori T et al. (2005) P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction. J Mol Cell Cardiol 39: 992-5 PubMed GONUTS page

[PMID:8910399-16] Kimura T et al. (1996) Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor. J Biol Chem 271: 27962-8 PubMed GONUTS page

[PMID:10612430-17] Páez-Espinosa EV et al. (1999) Insulin-induced tyrosine phosphorylation of Shc in liver, muscle and adipose tissue of insulin resistant rats. Mol Cell Endocrinol 156: 121-9 PubMed GONUTS page

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RAT:SHC1

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